Results 211 to 220 of about 88,369 (298)

MSCs overexpressing FGF21 alleviate acetaminophen-induced acute liver injury by eliciting macrophage-mediated phagocytosis. [PDF]

open access: yesHepatol Commun
Huai Q   +13 more
europepmc   +1 more source

Use of Intralipid Therapy and Therapeutic Plasma Exchange in the Management of Cholecalciferol Rodenticide Exposure in a Dog: A Case Report

open access: yesJournal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To describe the presentation and outcome of a case of suspected cholecalciferol rodenticide intoxication managed with both intralipid emulsion (ILE) and therapeutic plasma exchange (TPE). Case Summary A 3‐year‐old, neutered female, crossbreed dog presented for acute‐onset vomiting and lethargy after suspected exposure to ...
Tanvi A. Kamat   +3 more
wiley   +1 more source

Serum Baclofen Concentrations in Four Dogs With Baclofen Toxicosis Treated With In‐Series Carbon Hemoperfusion and Hemodialysis

open access: yesJournal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To report serum baclofen concentrations before, during, and after in‐series carbon hemoperfusion (cHP) and hemodialysis (HD) in four dogs with severe baclofen toxicosis. Series Summary This series involves four dogs with serum samples collected before, during, and after in‐series cHP/HD.
Amanda Spillane   +4 more
wiley   +1 more source

Human placental transfer of xenobiotics in health and disease: New approach methodologies for developmental and reproductive toxicology testing and mathematical modelling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend New approach methodologies (NAMs) to test the pharmaco‐ and chemicokinetics of compound transfer across the human placental barrier in late pregnancy. Abstract This review addresses an important and timely topic at the intersection of placental biology with respect to barrier transfer kinetics, toxicology and mathematical ...
Paul Brownbill, Eleanor Doman
wiley   +1 more source

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor   +4 more
wiley   +1 more source

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