Results 1 to 10 of about 58,096 (266)

Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning.

open access: yesPLoS Medicine, 2007
BackgroundParacetamol (acetaminophen) poisoning is the leading cause of acute liver failure in Great Britain and the United States. Successful interventions to reduced harm from paracetamol poisoning are needed.
Oliver W Morgan   +2 more
doaj   +1 more source

Role of amifostine in preventing liver injury caused by paracetamol intoxication

open access: yesMedicine Science
This investigation attempted to examine the possible protective impact of amifostine, alone or in combination with N-acetylcysteine (NAC), in paracetamol-induced liver injury.
Fatih Turkmen   +8 more
doaj   +1 more source

Investigation of the effect of paracetamol against glutamate-induced cytotoxicity in C6 glia cells

open access: yesCumhuriyet Science Journal, 2021
Paracetamol is an active metabolite with analgesic and antipyretic properties of phenacetin, which is sold without a prescription in our country and in many countries.
Kenan Yıldızhan, Murat Doğan
doaj  

Comparison of preemptive paracetamol, paracetamol-diclofenac & paracetamol-tramadol combination on postoperative pain after elective abdominal surgery under general anesthesia, Ethiopia: a randomized control trial study, 2018

open access: yesBMC Anesthesiology, 2020
Background In the practice of postoperative pain management, pain is still poorly managed in low resource setting where the practice of epidural and opioid free analgesia is impractical.
Zemedu Aweke   +3 more
doaj   +1 more source

Paracetamol use in pregnancy: Not as safe as we may think?

open access: yesActa Obstetricia et Gynecologica Scandinavica, 2023
Paracetamol is used by more than 50% of women worldwide during pregnancy; headache representing the most frequent indication. Several studies report that long‐term exposure to paracetamol in utero is associated with adverse neurodevelopmental outcomes in
Katinka Nilsen   +2 more
doaj   +1 more source

Paracetamol cardiotoxicity [PDF]

open access: yesPostgraduate Medical Journal, 1993
Summary A 29 year old man with a significant paracetamol overdose was found to have an abnormal electrocardiograph which, in the absence of hepatic encephalopathy, was considered due to a direct cardiotoxic effect of the drug. A functional coronary insufficiency resulting from inhibition of endothelium-derived relaxing factor secondary ...
A, Armour, S D, Slater
openaire   +2 more sources

Hepatoprotective effect of punica granatum seed oil extract on paracetamol intoxication in rat via inhibory effect of cyp2e1 [PDF]

open access: yesKafkas Universitesi Veteriner Fakültesi Dergisi, 2018
Punica granatum seed oil enriched by punikalagins has been shown to have a therapeutic effect against antidiabetic, anticancer, antiinflammatory and some organ toxicities. We aimed to reveal both protective and therapeutic effects of punica granatum seed
Damla CETIN   +3 more
doaj   +1 more source

Estimation of paracetamol in urine to assess the diurnal variation

open access: yesBangabandhu Sheikh Mujib Medical University Journal, 2018
The aim of the present study was to evaluate the diurnal variation of the pharmacokinetics of paracetamol by estimating the urinary free paracetamol level after single oral administration of paracetamol (500 mg) tablet to 24 healthy male volunteers ...
Mithun Chandro Bhowmik   +2 more
doaj   +1 more source

Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial

open access: yesCurrent Therapeutic Research, 2014
Background: Strong opioids in the home setting after ambulatory surgery have rarely been studied for fear of hazardous adverse effects such as respiratory depression.
Björn Stessel, MD   +6 more
doaj   +1 more source

Paracetamol-codeine combinations versus paracetamol alone [PDF]

open access: yesBMJ, 1996
EDITOR,—In their systematic review Anton J M de Craen and colleagues conclude, on the basis of a range of outcome measures, that the combination of paracetamol and codeine is a more effective analgesic than paracetamol alone.1 They find the increase in efficacy to be small but significant and suggest that future studies should report the proportion of ...
A, Li Wan Po, W Y, Zhang
openaire   +2 more sources

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