Results 31 to 40 of about 58,096 (266)

Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America

Toxicology Reports, 2022
Paracetamol, also known as acetaminophen (N-acetyl-para-aminophenol, APAP) is the world’s most used over-the-counter analgesic-antipyretic drug. Despite its good safety profile, acetaminophen can cause severe hepatotoxicity in overdose, and poisoning ...
Samuel James Offor, Cecilia Nwadiuto Amadi, Ifeyinwa Chijioke-Nwauche, Jose E. Manautou, Orish E. Orisakwe   +4 more
doaj   +1 more source

Acetaminophen (Paracetamol) [PDF]

Journal of Pain and Symptom Management, 2013
Therapeutic Reviews aim to provide essential independent information for health professionals about drugs used in palliative and hospice care. Additional content is available on www.palliativedrugs.com. Country-specific books (Hospice and Palliative Care Formulary USA, and Palliative Care Formulary, British and Canadian editions) are also available and
Robert, Twycross, Victor, Pace, Mary, Mihalyo, Andrew, Wilcock   +3 more
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

A Return to Normality: A Descriptive Qualitative Interview Study Exploring the Patient Experience of Gout Flare Resolution

Arthritis Care &Research, EarlyView.
Objective Although the definition of a gout flare is well established, the state of gout flare resolution has not yet been defined. This study aimed to explore patients’ experiences and perceptions of gout flare resolution. Methods Semistructured interviews were conducted with 24 people with gout, guided by open‐ended questions exploring their ...
Sarah Stewart, Anne Horne, Angelo Gaffo, Lisa K. Stamp, N. Lawrence Edwards, Nicola Dalbeth   +5 more
wiley   +1 more source

The Importance of Hypothermia in the Effects of Paracetamol on the Electrical Activity of the Brain in Pentylenetetrazole Induced Experimental Status Epilepticus in Rats

Archives of Epilepsy, 2020
Objectives:Paracetamol is a commonly used analgesic and antipyretic agent. In studies investigating the effects of paracetamol on seizure activity, to our knowledge, the hypothermic effect has not been evaluated in studies investigating the hypothermic ...
Semiha KURT, Hatice AYGÜN, Şeyma ÖZSOY, Betül ÇEVİK, Dürdane AKSOY, Orhan SÜMBÜL   +5 more
doaj   +1 more source

Bismuth‐Based Photocatalysts for Water Remediation: Design Strategies, Mechanisms, and Challenges

Advanced Functional Materials, EarlyView.
This review highlights representative design strategies for bismuth‐based semiconductor photocatalysts in solar‐driven water purification. Emphasis is placed on electronic structure regulation, oxygen‐vacancy engineering, and interfacial coupling to enable efficient full‐spectrum light utilization, improved charge separation, and selective oxidation in
Shan Liu, Yi Zhao, Liming Cai, Simin Long, Jing Kang, Jingkai Lin, Jimin Shen, Zhonglin Chen, Shaobin Wang, Huayang Zhang   +9 more
wiley   +1 more source

Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery

Journal of Applied Polymer Science, EarlyView.
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale, Madhur Kulkarni, Pranav J. Shah, Furqan A. Maulvi   +3 more
wiley   +1 more source

Microbial paracetamol degradation involves a high diversity of novel amidase enzyme candidates

Water Research X, 2022
Pharmaceuticals are relatively new to nature and often not completely removed in wastewater treatment plants (WWTPs). Consequently, these micropollutants end up in water bodies all around the world posing a great environmental risk. One exception to this
Ana B. Rios-Miguel, Garrett J. Smith, Geert Cremers, Theo van Alen, Mike S.M. Jetten, Huub J.M. Op den Camp, Cornelia U. Welte   +6 more
doaj   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Vitamin E is a potent regulator of inflammatory cytokines released during hepatic toxicity in rats [PDF]

Benha Veterinary Medical Journal, 2018
Paracetamol is a the most utilized analgesic and antipyretic drug, but it may induce hepatotoxicity at increased doses. So, we design this experiment to study the hepatotoxic effect of paracetamol and to detect the role of vitamin E in the alleviation of
Ayman Samir Farid, Mona A. El Shemy
doaj   +1 more source