Results 31 to 40 of about 169,592 (332)

Hepatoprotective effect of punica granatum seed oil extract on paracetamol intoxication in rat via inhibory effect of cyp2e1 [PDF]

open access: yesKafkas Universitesi Veteriner Fakültesi Dergisi, 2018
Punica granatum seed oil enriched by punikalagins has been shown to have a therapeutic effect against antidiabetic, anticancer, antiinflammatory and some organ toxicities. We aimed to reveal both protective and therapeutic effects of punica granatum seed
Damla CETIN   +3 more
doaj   +1 more source

Comparison of preemptive paracetamol, paracetamol-diclofenac & paracetamol-tramadol combination on postoperative pain after elective abdominal surgery under general anesthesia, Ethiopia: a randomized control trial study, 2018

open access: yesBMC Anesthesiology, 2020
Background In the practice of postoperative pain management, pain is still poorly managed in low resource setting where the practice of epidural and opioid free analgesia is impractical.
Zemedu Aweke   +3 more
doaj   +1 more source

One‐Pot Amidation/C─H Halogenation by an Efficient Electrochemical Cascade

open access: yesAngewandte Chemie, EarlyView.
A sustainable electrochemical cascade enables the one‐pot synthesis of regioselectively halogenated N‐aryl amides from readily available amines and acyl halides under mild conditions. The method merges amidation and C─H halogenation in a single operational step, delivering broad substrate scope, high selectivity, and scalability, and provides an ...
Sudipta Ponra   +8 more
wiley   +2 more sources

Estimation of paracetamol in urine to assess the diurnal variation

open access: yesBangabandhu Sheikh Mujib Medical University Journal, 2018
The aim of the present study was to evaluate the diurnal variation of the pharmacokinetics of paracetamol by estimating the urinary free paracetamol level after single oral administration of paracetamol (500 mg) tablet to 24 healthy male volunteers ...
Mithun Chandro Bhowmik   +2 more
doaj   +1 more source

Paracetamol-codeine combinations versus paracetamol alone [PDF]

open access: yesBMJ, 1996
EDITOR,—In their systematic review Anton J M de Craen and colleagues conclude, on the basis of a range of outcome measures, that the combination of paracetamol and codeine is a more effective analgesic than paracetamol alone.1 They find the increase in efficacy to be small but significant and suggest that future studies should report the proportion of ...
A, Li Wan Po, W Y, Zhang
openaire   +2 more sources

Investigation of the effect of paracetamol against glutamate-induced cytotoxicity in C6 glia cells

open access: yesCumhuriyet Science Journal, 2021
Paracetamol is an active metabolite with analgesic and antipyretic properties of phenacetin, which is sold without a prescription in our country and in many countries.
Kenan Yıldızhan, Murat Doğan
doaj  

Paracetamol use in pregnancy: Not as safe as we may think?

open access: yesActa Obstetricia et Gynecologica Scandinavica, 2023
Paracetamol is used by more than 50% of women worldwide during pregnancy; headache representing the most frequent indication. Several studies report that long‐term exposure to paracetamol in utero is associated with adverse neurodevelopmental outcomes in
Katinka Nilsen   +2 more
doaj   +1 more source

Role of amifostine in preventing liver injury caused by paracetamol intoxication

open access: yesMedicine Science
This investigation attempted to examine the possible protective impact of amifostine, alone or in combination with N-acetylcysteine (NAC), in paracetamol-induced liver injury.
Fatih Turkmen   +8 more
doaj   +1 more source

Impact of paracetamol pack size restrictions on poisoning from paracetamol in England and Wales: an observational study.

open access: yes, 2005
BACKGROUND: About 500 drug poisoning deaths involving paracetamol (acetaminophen) occur every year in England and Wales. To reduce the number of deaths, regulations were introduced in 1998 to restrict the sale of paracetamol.
Griffiths, Clare   +2 more
core   +1 more source

Restricting paracetamol in the United Kingdom to reduce poisoning: a systematic review

open access: yes, 2005
Background Paracetamol poisoning is implicated in about 150-200 poisoning deaths per year in England and Wales. We review previous studies assessing the effectiveness of regulations introduced in 1998 to restrict sales of paracetamol and reduce ...
Majeed, A, Morgan, O
core   +1 more source

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