Results 41 to 50 of about 76,985 (314)

The Importance of Hypothermia in the Effects of Paracetamol on the Electrical Activity of the Brain in Pentylenetetrazole Induced Experimental Status Epilepticus in Rats

Archives of Epilepsy, 2020
Objectives:Paracetamol is a commonly used analgesic and antipyretic agent. In studies investigating the effects of paracetamol on seizure activity, to our knowledge, the hypothermic effect has not been evaluated in studies investigating the hypothermic ...
Semiha KURT, Hatice AYGÜN, Şeyma ÖZSOY, Betül ÇEVİK, Dürdane AKSOY, Orhan SÜMBÜL   +5 more
doaj   +1 more source

Microbial paracetamol degradation involves a high diversity of novel amidase enzyme candidates

Water Research X, 2022
Pharmaceuticals are relatively new to nature and often not completely removed in wastewater treatment plants (WWTPs). Consequently, these micropollutants end up in water bodies all around the world posing a great environmental risk. One exception to this
Ana B. Rios-Miguel, Garrett J. Smith, Geert Cremers, Theo van Alen, Mike S.M. Jetten, Huub J.M. Op den Camp, Cornelia U. Welte   +6 more
doaj   +1 more source

Development of immunocompetent models for primary and metastatic ER+ breast cancer

Animal Models and Experimental Medicine, EarlyView.
This study explores syngeneic, immunocompetent models of ER+ breast cancer in 129S6/SvEv mice, using trackable tumor cells to model both primary tumors and metastasis. The models show promise, while also revealing limitations for studying advanced disease and immune interactions.
Devon M. Bull, Jody Hazlett, Emily Schulpen, Sophie Tunnicliffe, Alexander D. McLellan, Anita K. Dunbier   +5 more
wiley   +1 more source

Paracetamol-codeine combinations versus paracetamol alone [PDF]

BMJ, 1996
EDITOR,—In their systematic review Anton J M de Craen and colleagues conclude, on the basis of a range of outcome measures, that the combination of paracetamol and codeine is a more effective analgesic than paracetamol alone.1 They find the increase in efficacy to be small but significant and suggest that future studies should report the proportion of ...
A, Li Wan Po, W Y, Zhang
openaire   +2 more sources

Design And Evaluation Of Controlled Release Layered Matrix Tablets Of Paracetamol And Verapamil Hci. [PDF]

, 2009
Tablet matriks berlapis pelepasan terkawal parasetamol dan verapamil HCl dibangunkan menggunakan polimer hidrofilik dan hidrofobik, dan disediakan dengan kaedah pengranulan basah.
Rahamathullah, Shaikh
core  

Vitamin E is a potent regulator of inflammatory cytokines released during hepatic toxicity in rats [PDF]

Benha Veterinary Medical Journal, 2018
Paracetamol is a the most utilized analgesic and antipyretic drug, but it may induce hepatotoxicity at increased doses. So, we design this experiment to study the hepatotoxic effect of paracetamol and to detect the role of vitamin E in the alleviation of
Ayman Samir Farid, Mona A. El Shemy
doaj   +1 more source

Prescribing competence: The pros and cons of different methods for assessment

British Journal of Clinical Pharmacology, EarlyView.
Evaluating a medical graduate’s competence in rational prescribing is challenging. With the aim to guide and inspire teachers, this narrative review explores different methods that can be used to assess prescribing competence. Each method has its own advantages and disadvantages, and thus a mix of different assessment methods is needed throughout the ...
David J. Brinkman, Erik M. Donker, Jelle Tichelaar, on behalf of the CP4T programme   +3 more
wiley   +1 more source

The association of prior paracetamol intake with outcome of very old intensive care patients with COVID-19: results from an international prospective multicentre trial

BMC Geriatrics, 2022
Background In the early COVID-19 pandemic concerns about the correct choice of analgesics in patients with COVID-19 were raised. Little data was available on potential usefulness or harmfulness of prescription free analgesics, such as paracetamol.
Philipp Heinrich Baldia, Bernhard Wernly, Hans Flaatten, Jesper Fjølner, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Malte Kelm, Michael Beil, Raphael Romano Bruno, Stephan Binnebößel, Georg Wolff, Ralf Erkens, Sviri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Brian Marsh, Finn H. Andersen, Rui Moreno, Susannah Leaver, Dylan W. De Lange, Bertrand Guidet, Christian Jung, COVIP study group   +26 more
doaj   +1 more source

The integration of the British Pharmacological Society's prescription safety assessment into the WHO 6‐step model of rational pharmacotherapy in a Turkish medical school

British Journal of Clinical Pharmacology, EarlyView.
Aims At Koç University School of Medicine, a one‐week rational pharmacotherapy (RPHM) programme, modelled after WHO 6‐step, has been introduced in the fourth‐year curriculum to improve prescription skills. For efficient problem‐based learning (PBL) sessions on a prespecified topic, students need to brush up on basic pharmacology knowledge, so we ...
Sinem Ezgi Gülmez, Gülnihal Özcan, Hakan S. Orer   +2 more
wiley   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source