Results 41 to 50 of about 93,899 (311)
Paracetamol cardiotoxicity [PDF]
Postgraduate Medical Journal, 1993 Summary A 29 year old man with a significant paracetamol overdose was found to have an abnormal electrocardiograph which, in the absence of hepatic encephalopathy, was considered due to a direct cardiotoxic effect of the drug. A functional coronary insufficiency resulting from inhibition of endothelium-derived relaxing factor secondary ...
A, Armour, S D, Slater
openaire +2 more sources
NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]
, 2014 The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Teemu P. Miettinen +3 more
core +1 more source
Toxicology Reports, 2022 Paracetamol, also known as acetaminophen (N-acetyl-para-aminophenol, APAP) is the world’s most used over-the-counter analgesic-antipyretic drug. Despite its good safety profile, acetaminophen can cause severe hepatotoxicity in overdose, and poisoning ...
Samuel James Offor +4 more
doaj +1 more source
Acute liver failure in paracetamol overdose: management, transplantation and best practice [PDF]
, 2020 In the United Kingdom the most common drug taken in overdose is paracetamol, which is recognised as a major cause of acute liver failure. However death rates from acute liver failure have fallen due to the rapid availability and accessibility of the ...
Toplis, Emma, Mortimore, Gerri
core +1 more source
Role of amifostine in preventing liver injury caused by paracetamol intoxication
Medicine ScienceThis investigation attempted to examine the possible protective impact of amifostine, alone or in combination with N-acetylcysteine (NAC), in paracetamol-induced liver injury.
Fatih Turkmen +8 more
doaj +1 more source
Investigation of the effect of paracetamol against glutamate-induced cytotoxicity in C6 glia cells
Cumhuriyet Science Journal, 2021 Paracetamol is an active metabolite with analgesic and antipyretic properties of phenacetin, which is sold without a prescription in our country and in many countries.
Kenan Yıldızhan, Murat Doğan
doaj
Paracetamol use in pregnancy: Not as safe as we may think?
Acta Obstetricia et Gynecologica Scandinavica, 2023 Paracetamol is used by more than 50% of women worldwide during pregnancy; headache representing the most frequent indication. Several studies report that long‐term exposure to paracetamol in utero is associated with adverse neurodevelopmental outcomes in
Katinka Nilsen +2 more
doaj +1 more source
A paracetamol-morpholine adduct
, 2002 Paracetamol [also known as acetaminophen or N-(4-hydroxyphenyl) acetamide] is an important analgesic drug that has recently been cocrystallized with a series of cyclic N- and Odonor compounds.
Parsons, S +3 more
core +3 more sources
BMC Anesthesiology, 2020 Background In the practice of postoperative pain management, pain is still poorly managed in low resource setting where the practice of epidural and opioid free analgesia is impractical.
Zemedu Aweke +3 more
doaj +1 more source
Hepatoprotective effect of punica granatum seed oil extract on paracetamol intoxication in rat via inhibory effect of cyp2e1 [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018 Punica granatum seed oil enriched by punikalagins has been shown to have a therapeutic effect against antidiabetic, anticancer, antiinflammatory and some organ toxicities. We aimed to reveal both protective and therapeutic effects of punica granatum seed
Damla CETIN +3 more
doaj +1 more source