Results 1 to 10 of about 98,702 (252)
Simultaneous Detection of Drug-Induced Liver Injury Protein and microRNA Biomarkers Using Dynamic Chemical Labelling on a Luminex MAGPIX System [PDF]
Analytica, 2021 Drug-induced liver injury (DILI) is a potentially fatal adverse event and a leading cause for pre- and post-marketing drug withdrawal. Several multinational DILI initiatives have now recommended a panel of protein and microRNA (miRNA) biomarkers that can
Antonio Marín-Romero +8 more
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MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury [PDF]
Journal of Clinical Medicine, 2015 Drug-induced liver injury (DILI) is major problem for both the drug industry and for clinicians. There are two basic categories of DILI: intrinsic and idiosyncratic. The former is the chief cause of acute liver failure in several developed countries, while the latter is the most common reason for post-marketing drug withdrawal and a major reason for ...
Mitchell R Mcgill +2 more
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The chemical, genetic and immunological basis of idiosyncratic drug–induced liver injury [PDF]
Human and Experimental Toxicology, 2015 Idiosyncratic drug reactions can be extremely severe and are not accounted for by the regular pharmacology of a drug. Thus, the mechanism of idiosyncratic drug–induced liver injury (iDILI), a phenomenon that occurs with many drugs including β-lactams, anti-tuberculosis drugs and non-steroidal anti-inflammatories, has been difficult to determine and ...
Dean Naisbitt
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Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure [PDF]
Biology Direct, 2021 Background Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are ...
Anika Liu +7 more
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Frontiers in Genetics, 2022 Drug-Induced Liver Injury (DILI), despite its low occurrence rate, can cause severe side effects or even lead to death. Thus, it is one of the leading causes for terminating the development of new, and restricting the use of already-circulating, drugs.
Sanjay Rathee, Namshik Han, Anika Liu
exaly +4 more sources
Gazi Medical JournalLiver injury is commonly seen in the population depending on the drug and chemical usage. Different groups of drugs and chemicals lead to different pathogeneses in the liver, such as necrosis, fibrosis, or inflammation.
Müşerref Şeyma Ceyhan +2 more
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Editorial of Special Column on Drug- and Chemical-Induced Liver Injury
Acta Pharmaceutica Sinica B, 2021 James Luyendyk, Dafna Groeneveld
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Advanced human liver models for the assessment of drug-induced liver injury [PDF]
Organoid, 2022 Drug safety issues continue to occur even with drugs that are approved after the completion of clinical studies. Drug-induced liver injury (DILI) is a major obstacle to drug development, because the liver is the primary site of drug metabolism, and ...
Seon Ju Mun +3 more
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Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice [PDF]
Acta Cirúrgica Brasileira, 2020 Purpose To investigate the effect of growth arrest-specific protein 6 (Gas6) on acute liver injury in mice and related mechanisms. Methods Thirty C57BL/6 (6-8 weeks old) mice were randomly divided into control, LPS/D-GalN, and LPS/D-GalN+Gas6 groups ...
Qian Wang, Yang Zhao, Bin Zang
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Gut Microbiota and Chemical-Induced Acute Liver Injury
Frontiers in Physiology, 2021 Background: Drug overdose or chemical exposures are the main causes of acute liver injury (ALI). Severe liver injury can develop into liver failure that is an important cause of liver-related mortality in intensive care units in most countries ...
Tao Chen, Tao Chen, Rui Li, Peng Chen
doaj +1 more source