Results 1 to 10 of about 97,405 (118)

Editorial of Special Column on Drug- and Chemical-Induced Liver Injury

Acta Pharmaceutica Sinica B, 2021
James Luyendyk, Dafna Groeneveld
doaj   +1 more source

The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled

Hepatology Communications, 2019
The U.S. Drug Induced Liver Injury Network assayed the contents of herbal and dietary supplements collected from patients enrolled into its prospective study.
Victor Navarro, Bharathi Avula, Ikhlas Khan, Manisha Verma, Leonard Seeff, Jose Serrano, Andrew Stolz, Robert Fontana, Jawad Ahmad   +8 more
doaj   +1 more source

Hepatoprotective Effects of Curcumin and Thymoquinone Against Chemically Induced Liver Injury: A Schematic Study with Meta-Analysis of Antioxidant and Anti-inflammatory Outcomes

Pakistan Journal of Medicine and Dentistry
Background: Curcumin and thymoquinone are phytochemicals that have shown the ability to protect the liver in previous studies, with involvement of their antioxidant and anti-inflammatory activity. This study aimed to examine the effective concentrations
Madiha Niamat, Mohammad Abid, Abdul Rehman Khalil Shaikh, Sana Masood, Fiza   +4 more
doaj   +1 more source

Development of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state

Scientific Reports
Chronic liver injury induces fibrosis that often proceeds to cirrhosis and hepatocellular carcinoma, indicating that prevention and/or resolution of fibrosis is a promising therapeutic target.
Yasuhiro Nakano, Eiko Saijou, Tohru Itoh, Minoru Tanaka, Atsushi Miyajima, Taketomo Kido   +5 more
doaj   +1 more source

Drug-induced liver injury in children: A nationwide cohort study from China

JHEP Reports
Background & Aims: Currently, there is limited knowledge on the clinical profile of drug-induced liver injury (DILI) in Chinese children. We aimed to assess the clinical characteristics, suspected drugs, and outcomes associated with pediatric DILI in
Rongtao Lai, Xinjie Li, Jie Zhang, Jun Chen, Changqing Yang, Wen Xie, Yuecheng Yu, Xiaoyan Guo, Xinrong Zhang, Guoliang Lu, Xi’an Han, Qing Xie, Chengwei Chen, Tao Shen, Yimin Mao   +14 more
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Antioxidant and hepatoprotective effect of Jatropha dioica against the valproic acid-induced damage in an in vivo model

BMC Complementary Medicine and Therapies
Background Understanding liver diseases is important worldwide due to their prevalence. Apart from liver disease arising from hepatitis C viral infection, most chronic liver diseases currently have no cure.
Paula Cordero-Pérez, Ramiro Tijerina-Márquez, Veronica Mayela Rivas-Galindo, Liliana Torres-González, Diana Raquel Rodríguez-Rodríguez, Oscar Humberto Mendoza-Hernández, César Bigran Espinosa-Cantú, Guadalupe Yazmín Solís-Cruz, Linda E. Muñoz-Espinosa, Edelmiro Pérez-Rodríguez, Idalia Cura-Esquivel, Gabriela Alarcón-Galván, Diana Patricia Moreno-Pena   +12 more
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Correlation between Kupffer Cell Infiltration and Liver Parenchymal Cell Damages in Immunosuppressed Drugs-Induced Rats

Majalah Kedokteran Bandung
The liver is the largest organ in the body, composed of both parenchymal and non-parenchymal cells. Chemical substances and various drugs can induce liver injury and involve Kupffer cells which are non-parenchymal cells that release biologically active ...
Agni Febrina Pargaputri, Endah Wahjuningsih, Dwi Andriani   +2 more
doaj   +1 more source

Hepatotoxicity of antipsychotics: an exploratory pharmacoepidemiologic and pharmacodynamic study integrating FAERS data and in vitro receptor-binding affinities

Frontiers in Psychiatry
IntroductionAntipsychotic psychopharmacotherapy is associated with the risk of drug-induced liver injury (DILI). However, understanding specific risk factors remains challenging due to limited data.
René Zeiss, Carlos Schönfeldt-Lecuona, Bernhard J. Connemann, Susanne Hafner, Maximilian Gahr   +4 more
doaj   +1 more source

Alpinetin pretreatment prevents lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by inhibiting ferroptosis via the Nrf2/SLC7A11/GPX4 pathway

Scientific Reports
This study aims to investigate whether alpinetin prevents lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute liver injury (ALI) in mice by inhibiting ferroptosis, and to explore the potential molecular mechanisms involved. Thirty-six male BALB/
Yujia Liu, Jiayue Zhao, Weihong Cong, Tonggang Liu, Kaihui Sha   +4 more
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Amoxicillin-Induced Drug-Induced Liver Injury Superimposed on Acute Hepatitis C Infection in a Patient With Hurler Syndrome: A Diagnostic Challenge Assessed by the Updated RUCAM. [PDF]

Case Reports Hepatol
Garg A, Seshie P, Chouthai A, Raval S, Santharaman A, Manzoor A, Broder A.   +6 more
europepmc   +1 more source