Results 11 to 20 of about 129,623 (319)

A General Overview of Mesenchymal Stem Cell Therapies in Drug- and Chemical-Induced Liver Injury Models [PDF]

Gazi Medical Journal
Liver injury is commonly seen in the population depending on the drug and chemical usage. Different groups of drugs and chemicals lead to different pathogeneses in the liver, such as necrosis, fibrosis, or inflammation.
Müşerref Şeyma Ceyhan, Suna Ömeroğlu, Zeynep Yığman   +2 more
doaj   +3 more sources

Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

Biology Direct, 2021
Background Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are ...
Anika Liu, Moritz Walter, Peter Wright, Aleksandra Bartosik, Daniela Dolciami, Abdurrahman Elbasir, Hongbin Yang, Andreas Bender   +7 more
doaj   +2 more sources

LIVER INJURY INDUCED BY HERBAL AND DIETARY SUPPLEMENTS: A POOLED ANALYSIS OF CASE REPORTS

Arquivos de Gastroenterologia, 2022
Background: The intake of dietary supplements and medicinal plants is very popular worldwide. However, these products are not innocuous, and their intake can cause severe damage to health, especially liver injury. Objective: This study aims to describe
Michelle Hoff de ASSIS, Bruna Cherubini ALVES, Vivian Cristine LUFT, Valesca DALL’ALBA   +3 more
doaj   +2 more sources

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury [PDF]

Archives of Toxicology, 2018
The transcription factor NRF2, governed by its repressor KEAP1, protects cells against oxidative stress. There is interest in modelling the NRF2 response to improve the prediction of clinical toxicities such as drug-induced liver injury (DILI).
I. Copple, W. den Hollander, G. Callegaro, F. Mutter, J. Maggs, Amy L. Schofield, L. Rainbow, Yong-Xiang Fang, J. Sutherland, Ewa C. S. Ellis, M. Ingelman-Sundberg, S. Fenwick, C. Goldring, B. van de Water, J. Stevens, B. Park   +15 more
semanticscholar   +5 more sources

pDILI_v1: A Web-Based Machine Learning Tool for Predicting Drug-Induced Liver Injury (DILI) Integrating Chemical Space Analysis and Molecular Fingerprints

ACS Omega
Drug-induced liver injury (DILI) represents a critical safety concern for drug development, regulatory oversight, and clinical practice, with substantial economic and public health implications.
S. Amin, Supratik Kar, Stefano Piotto
semanticscholar   +4 more sources

Editorial of Special Column on Drug- and Chemical-Induced Liver Injury

Acta Pharmaceutica Sinica B, 2021
James Luyendyk, Dafna Groeneveld
doaj   +3 more sources

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted In Vivo and In Vitro Data

Chemical Research in Toxicology
Drug-induced liver injury (DILI) has been a significant challenge in drug discovery, often leading to clinical trial failures and necessitating drug withdrawals.
Srijit Seal, Dominic P. Williams, L. Hosseini-Gerami, Manas Mahale, A. Carpenter, O. Spjuth, Andreas Bender   +6 more
semanticscholar   +3 more sources

Advanced human liver models for the assessment of drug-induced liver injury [PDF]

Organoid, 2022
Drug safety issues continue to occur even with drugs that are approved after the completion of clinical studies. Drug-induced liver injury (DILI) is a major obstacle to drug development, because the liver is the primary site of drug metabolism, and ...
Seon Ju Mun, Jaeseo Lee, Yongbo Shin, Myung Jin Son   +3 more
doaj   +1 more source

Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose To investigate the effect of growth arrest-specific protein 6 (Gas6) on acute liver injury in mice and related mechanisms. Methods Thirty C57BL/6 (6-8 weeks old) mice were randomly divided into control, LPS/D-GalN, and LPS/D-GalN+Gas6 groups ...
Qian Wang, Yang Zhao, Bin Zang
doaj   +1 more source

Gut Microbiota and Chemical-Induced Acute Liver Injury

Frontiers in Physiology, 2021
Background: Drug overdose or chemical exposures are the main causes of acute liver injury (ALI). Severe liver injury can develop into liver failure that is an important cause of liver-related mortality in intensive care units in most countries ...
Tao Chen, Tao Chen, Rui Li, Peng Chen
doaj   +1 more source