Results 31 to 40 of about 129,623 (319)

HEPATOPROTECTIVE EFFICACY OF METHANOLIC EXTRACT OF INDIGOFERA SUFFRUTICOSA (MILL) ON PARACETAMOL-INDUCED LIVER DAMAGE IN MICE [PDF]

Arquivos de Gastroenterologia, 2019
BACKGROUND: Indigofera suffruticosa Mill (Fabaceae) is abundant in northeastern Brazil and popularly used in the treatment of infectious and inflammatory processes.
Izabela Rangel LIMA, Ivanise Brito SILVA, Roberta M Leite LIMA, Tainá M Santos SILVA, Maria B Sousa MAIA, Sônia Pereira LEITE   +5 more
doaj   +1 more source

INFLUENCE OF HIGH-DOSE ATORVASTATIN ON BILE ACID METABOLISM IN MICE WITH LIVER INJURY AND RELATED MECHANISM [PDF]

精准医学杂志, 2023
Objective To investigate the influence of high-dose atorvastatin on bile acid metabolism in mice with liver injury and its mechanism. Methods A total of 40 specific pathogen-free male C57BL/6 mice were randomly divided into normal saline group (group A ...
XIA Feifei, SONG Bingxue, SONG Yuqing, TIAN Jiawei, YAN Hui, HUANG Yuxiao, XIN Hui, LIANG Hui
doaj   +1 more source

Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome

Critical Care, 2022
Background A higher-than-usual resistance to standard sedation regimens in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) has led to the frequent use of the second-line anaesthetic agent ketamine. Simultaneously, an increased
Pedro David Wendel-Garcia, Rolf Erlebach, Daniel Andrea Hofmaenner, Giovanni Camen, Reto Andreas Schuepbach, Christoph Jüngst, Beat Müllhaupt, Jan Bartussek, Philipp Karl Buehler, Rea Andermatt, Sascha David   +10 more
doaj   +1 more source

Carnitine in Alleviation of Complications Caused by Acute Valproic Acid Toxicity; an Exprimental Study on Mice

Archives of Academic Emergency Medicine, 2023
Introduction: Hyperammonemia and hepatotoxicity are well-known complications of valproic acid (VPA) poisoning. The objective of this study is to evaluate the potential role of carnitine in mitigating the adverse effects of acute VPA toxicity in mice ...
Akram Jamshidzadeh, Reza Heidari, Mahdie Shams, Melika Ebrahimi-sharghi, Sayed Mahdi Marashi   +4 more
doaj   +1 more source

Serum microRNA-122 predicts survival in patients with liver cirrhosis [PDF]

, 2012
Background: Liver cirrhosis is associated with high morbidity and mortality. MicroRNAs (miRs) circulating in the blood are an emerging new class of biomarkers.
Stefan Zeuzem, Albrecht Piiper (22854), Oliver Waidmann, Kronenberger, Bernd, Friederike Brunner, Verena Köberle (130993), Bernd Kronenberger (131004), Bernd Kronenberger, Verena Köberle, Waidmann, Oliver, Albrecht Piiper, Oliver Waidmann (130988), Piiper, Albrecht, Friederike Brunner (130998), Köberle, Verena, Brunner, Friederike, Zeuzem, Stefan, Stefan Zeuzem (22856)   +17 more
core   +2 more sources

Acute ethanol gavage attenuates hemorrhage/resuscitation-induced hepatic oxidative stress in rats [PDF]

, 2012
Acute ethanol intoxication increases the production of reactive oxygen species (ROS). Hemorrhagic shock with subsequent resuscitation (H/R) also induces ROS resulting in cellular and hepatic damage in vivo.
Henrich, Dirk, Marzi, Ingo, Lehnert, Mark, Wilhelm, Kerstin, Wang, Minhong, Relja, Borna   +5 more
core   +1 more source

Pharmacological correction of hepatotoxicity induced by anti-tuberculosis drugs

Лечащий Врач, 2023
Drug-induced liver injury are one of the most frequent undesirable effects of drug therapy in tuberculosis patients. Hepatoprotective drugs of various origin and chemical composition are used for the correction and prevention of drug-induced liver injury.
D. S. Sukhanov, E. V. Timofeev, Y. S. Alekseeva, K. A. Nagornova   +3 more
doaj   +1 more source

Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity

Toxicology Reports, 2019
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver injury in humans and a common chemical model to investigate genetic determinants of susceptibility to drug-induced liver injury (DILI).
Ajay C Donepudi, Michael J. Goedken, John D. Schuetz, José E Manautou   +3 more
doaj   +1 more source

Relevance of Pharmacogenomics to the Safe Use of Antimicrobials

Antibiotics, 2023
There has been widespread implementation of pharmacogenomic testing to inform drug prescribing in medical specialties such as oncology and cardiology. Progress in using pharmacogenomic tests when prescribing antimicrobials has been more limited, though a
Ann K. Daly
doaj   +1 more source

NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]

, 2014
The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Teemu P. Miettinen, Mikael Björklund, Miettinen, Teemu P., Björklund, Mikael   +3 more
core   +1 more source