Results 51 to 60 of about 103,692 (253)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Additional file 2 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 2: Figure S1. DILI label prediction performance (balanced accuracy) of RF and SVM models trained using the DILIrank (−vLessConcern) dataset and Mordred molecular descriptors for 5-fold LOCO-CV, external test set, and FDA validation set (Methods).
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Drug-induced liver injury (DILI) in pregnancy: a case report

Family Medicine & Primary Care Review
Drug-induced liver injury (DILI) must be taken into consideration when a pregnant woman takes medications and presents symptoms of acute or chronic hepatitis, hepatocellular, cholestatic or mixed, as it poses a danger to both mother and fetus.
Aleksandra Urban, Szymon Paruszewski, Dorota Prządka-Rabaniuk, Maria Strzelec, Justyna Teliga-Czajkowska, Jacek Sieńko, Krzysztof Czajkowski   +6 more
doaj   +1 more source

Additional file 3 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 3: Figure S2. DILI label prediction performance (balanced accuracy) of RF and SVM models trained using the DILIrank (−vLessConcern) dataset and protein target descriptors for 5-fold LOCO-CV, external test set, and FDA validation set (Methods).
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Inhibition of Drug‐Induced Liver Injury in Mice Using a Positively Charged Peptide That Binds DNA

Hepatology Communications, 2021
Hepatic cell death occurs in response to diverse stimuli such as chemical and physical damage. The exposure of intracellular contents such as DNA during necrosis induces a severe inflammatory response that has yet to be fully explored therapeutically ...
Pedro E. Marques, Sofie Vandendriessche, Thiago H.C. deOliveira, Helena Crijns, Mateus E. Lopes, Marfa Blanter, Sara Schuermans, Karen Yu, Fariba Poosti, Vincent Vanheule, Rik Janssens, Daiane Boff, Andreas J. Kungl, Gustavo B. Menezes, Mauro M. Teixeira, Paul Proost   +15 more
doaj   +1 more source

Towards Decoding Hepatotoxicity of Approved Drugs through Navigation of Multiverse and Consensus Chemical Spaces

Biomolecules, 2023
Drug-induced liver injury (DILI) is the principal reason for failure in developing drug candidates. It is the most common reason to withdraw from the market after a drug has been approved for clinical use.
Edgar López-López, José L. Medina-Franco   +1 more
doaj   +1 more source

Additional file 5 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 5: Figure S4. Enriched pathways across different feature importance cutoffs for SVM using the DILIrank (−vLessConcern) dataset. Enriched pathways are shown across different feature importance cutoffs which are identified by the percentile of DILI-enriched protein targets covered.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury [PDF]

Archives of Toxicology, 2018
The transcription factor NRF2, governed by its repressor KEAP1, protects cells against oxidative stress. There is interest in modelling the NRF2 response to improve the prediction of clinical toxicities such as drug-induced liver injury (DILI). However, very little is known about the makeup of the NRF2 transcriptional network and its response to ...
Copple, I.M., Hollander, W. den, Callegaro, G., Mutter, F.E., Maggs, J.L., Schofield, A.L., Rainbow, L., Fang, Y., Sutherland, J.J., Ellis, E.C., Ingelman-Sundberg, M., Fenwick, S.W., Goldring, C.E., Water, B. van de, Stevens, J.L., Park, B.K.   +15 more
openaire   +4 more sources