Results 1 to 10 of about 232,489 (257)

Drug-induced liver injury [PDF]

Yeungnam University Journal of Medicine, 2020
Drug-induced liver injury (DILI), including herbal and dietary supplement hepatotoxicity, is often passed lightly; however, it can lead to the requirement of a liver transplant or may even cause death because of liver failure.
Jeong Ill Suh
doaj   +4 more sources

Widely Targeted Liver Metabolomics Reveals Potential Biomarkers in Mice with Drug-Induced Liver Injury [PDF]

Metabolites
Background: Drug-induced liver injury (DILI), a major type of adverse drug reaction, has become one of the leading causes of acute liver injury and liver failure worldwide.
Jiangning Peng, Tingting Zhao, Xuehong Zhang, Hong Wang, Hui Li, Yan Liang   +5 more
doaj   +2 more sources

Semaglutide‐Induced Hepatic Injury: A Rare Case of Drug Induced Liver Injury [PDF]

Clinical Case Reports
Semaglutide, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is widely used for type 2 diabetes mellitus and has demonstrated hepatoprotective effects.
Rupayan Kundu, Lyudmila Shtoff
doaj   +2 more sources

Comparative Metabolomic Profiling of the Metabolic Differences of Δ9-Tetrahydrocannabinol and Cannabidiol

Molecules, 2022
More than one hundred cannabinoids have been found in cannabis. Δ9-Tetrahydrocannabinol (THC) is the recognized addictive constituent in cannabis; however, the mechanisms underlying THC-induced toxicity remain elusive.
Qianru Rao, Ting Zhang, Manyun Dai, Bin Li, Qianlun Pu, Min Zhao, Yan Cheng, Dongmei Yan, Qi Zhao, Zhanxuan E. Wu, Fei Li   +10 more
doaj   +1 more source

Metabolic Profile of C-Prenyl Coumarins Using Mass Spectrometry-Based Metabolomics

Molecules, 2021
C-prenyl coumarins (C-PYCs) are compounds with similar structures and various bioactivities, which are widely distributed in medicinal plants. Until now, the metabolic characterizations of C-PYCs and the relationship between metabolism and bioactivities ...
Yan Cheng, Xiaofang Ma, Qi Zhao, Chunyan Wang, Dongmei Yan, Fei Li   +5 more
doaj   +1 more source

Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice

Nature Communications, 2023
Parabacteroides distasonis (P. distasonis), part of the gut microbiome, was reported to play a role in diabetes, colorectal cancer and inflammatory bowel disease. Here the authors report that P.
Qi Zhao, Man-Yun Dai, Ruo-Yue Huang, Jing-Yi Duan, Ting Zhang, Wei-Min Bao, Jing-Yi Zhang, Shao-Qiang Gui, Shu-Min Xia, Cong-Ting Dai, Ying-Mei Tang, Frank J. Gonzalez, Fei Li   +12 more
doaj   +1 more source

Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analysis

BMC Medical Genetics, 2020
Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. Current studies have shown that PNPLA3 (Patatin-like phospholipase domain containing 3) rs738409 G/C gene polymorphism is associated ...
Shan Tang, Jing Zhang, Ting Ting Mei, Hai Qing Guo, Xin Huan Wei, Wen Yan Zhang, Ya Li Liu, Shan Liang, Zuo Peng Fan, Li Xia Ma, Wei Lin, Yi Rong Liu, Li Xia Qiu, Hai Bin Yu   +13 more
doaj   +1 more source

Mechanisms of isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review

Frontiers in Pharmacology, 2022
Isoniazid (INH) and rifampicin (RFP) are the first-line medications for tuberculosis treatment, and liver injury is the major adverse effect. Natural medicinal ingredients provide distinct benefits in alleviating patients’ symptoms, lowering the liver ...
Xiuping Zhuang, Xiuping Zhuang, Li Li, Tianyi Liu, Rui Zhang, Peimin Yang, Xin Wang, Long Dai   +7 more
doaj   +1 more source

United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts

Toxicology Reports, 2020
As part of the United States Pharmacopeia’s ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed.
Hellen A. Oketch-Rabah, Amy L. Roe, Cynthia V. Rider, Herbert L. Bonkovsky, Gabriel I. Giancaspro, Victor Navarro, Mary F. Paine, Joseph M. Betz, Robin J. Marles, Steven Casper, Bill Gurley, Scott A. Jordan, Kan He, Mahendra P. Kapoor, Theertham P. Rao, Averell H. Sherker, Robert J. Fontana, Simona Rossi, Raj Vuppalanchi, Leonard B. Seeff, Andrew Stolz, Jawad Ahmad, Christopher Koh, Jose Serrano, Tieraona Low Dog, Richard Ko   +25 more
doaj   +1 more source

Association of TM6SF2 rs58542926 T/C gene polymorphism with hepatocellular carcinoma: a meta-analysis

BMC Cancer, 2019
Background Hepatocellular carcinoma (HCC) is the sixth-most common malignancy worldwide. Multiple previous studies have assessed the relationship between TM6SF2 gene polymorphism and the risk of developing HCC, with discrepant conclusions reached.
Shan Tang, Jing Zhang, Ting-Ting Mei, Hai-Qing Guo, Xin-Huan Wei, Wen-Yan Zhang, Ya-Li Liu, Shan Liang, Zuo-Peng Fan, Li-Xia Ma, Wei Lin, Yi-Rong Liu, Li-Xia Qiu, Hai-Bin Yu   +13 more
doaj   +1 more source