Results 1 to 10 of about 79,419 (267)

The molecular pathogenesis of triptolide-induced hepatotoxicity

Frontiers in Pharmacology, 2022
Triptolide (TP) is the major pharmacologically active ingredient and toxic component of Tripterygium wilfordii Hook. f. However, its clinical potential is limited by a narrow therapeutic window and multiple organ toxicity, especially hepatotoxicity ...
Liu Xueying
exaly   +3 more sources

Prevalence, perceptions and factors associated with non-adherence to hepatotoxicity monitoring among people living with HIV on tuberculosis preventive treatment at Mulago ISS clinic. [PDF]

PLoS ONE
IntroductionHepatotoxicity monitoring is recommended for people living with HIV (PLHIV) enrolled on tuberculosis preventive treatment (TPT). Despite a 7.3% hepatotoxicity incidence reported in a multi-country study, implementation and adherence to ...
Kevin Naturinda, Irene Andia Biraro, Ezekiel Mupere, Anthony Muyunga, Racheal Namutale Nalule, Benard Owori, Linda Dorothy Akot, Jovan Mugerwa, Arthur Shem Kasambula, Joseph Rubeihayo, Joan Kalyango   +10 more
doaj   +2 more sources

Association of Cytochrome P450 2E1 and N-Acetyltransferase 2 Genotypes with Serum Isoniazid Level and Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Cross-Sectional Study [PDF]

Iranian Journal of Medical Sciences, 2023
Background: Anti-tuberculosis drug-induced hepatotoxicity can result from genetic polymorphism of the isoniazid (INH) metabolizing enzyme. This study aimed to determine the effect of genetic polymorphism of N-acetyltransferase 2 (NAT2) and cytochrome ...
Nasir Pourmohamadi, Mihan Pour Abdollah Toutkaboni, Nasim Hayati Roodbari, Payam Tabarsi, Shadi Baniasad   +4 more
doaj   +1 more source

Machine Learning Approaches to Predict Hepatotoxicity Risk in Patients Receiving Nilotinib

Molecules, 2021
Background: Although nilotinib hepatotoxicity can cause severe clinical conditions and may alter treatment plans, risk factors affecting nilotinib-induced hepatotoxicity have not been investigated.
Jung-Sun Kim, Ji-Min Han, Yoon-Sook Cho, Kyung-Hee Choi, Hye-Sun Gwak   +4 more
doaj   +1 more source

United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts

Toxicology Reports, 2020
As part of the United States Pharmacopeia’s ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed.
Hellen A. Oketch-Rabah, Amy L. Roe, Cynthia V. Rider, Herbert L. Bonkovsky, Gabriel I. Giancaspro, Victor Navarro, Mary F. Paine, Joseph M. Betz, Robin J. Marles, Steven Casper, Bill Gurley, Scott A. Jordan, Kan He, Mahendra P. Kapoor, Theertham P. Rao, Averell H. Sherker, Robert J. Fontana, Simona Rossi, Raj Vuppalanchi, Leonard B. Seeff, Andrew Stolz, Jawad Ahmad, Christopher Koh, Jose Serrano, Tieraona Low Dog, Richard Ko   +25 more
doaj   +1 more source

Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS. [PDF]

PLoS ONE, 2016
Hepatotoxicity is frequently reported as an adverse reaction during the treatment of tuberculosis. The aim of this study was to determine the incidence of hepatotoxicity and to identify predictive factors for developing hepatotoxicity after people living
Carolline Araújo-Mariz, Edmundo Pessoa Lopes, Bartolomeu Acioli-Santos, Magda Maruza, Ulisses Ramos Montarroyos, Ricardo Arraes de Alencar Ximenes, Heloísa Ramos Lacerda, Demócrito de Barros Miranda-Filho, Maria de Fátima P Militão de Albuquerque   +8 more
doaj   +1 more source

Successful Treatment with Lorlatinib after the Development of Alectinib-Induced Liver Damage in ALK-Positive Non-Small-Cell Lung Cancer: A Case Report

Case Reports in Oncology, 2021
Alectinib is a key drug for treating anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC). Alectinib-induced hepatotoxicity is less common than that through other ALK inhibitors, such as crizotinib or ceritinib.
Go Makimoto, Keita Kawakado, Masamoto Nakanishi, Tomoki Tamura, Shoichi Kuyama   +4 more
doaj   +1 more source

Navigating liver cancer with mouse models: a comprehensive overview of HCC experimental systems [PDF]

Journal of Liver Cancer
Hepatocellular carcinoma (HCC) is the most prevalent primary hepatic malignancy and is globally the third leading cause of cancerrelated deaths. Despite significant advancements in diagnostic techniques and therapeutic interventions, HCC prognosis ...
Ga-Young Kim, Dokyung Kim, Jaehyun Jeon, Wonhyo Seo, Seol Hee Park   +4 more
doaj   +1 more source

Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine [PDF]

Advanced Pharmaceutical Bulletin, 2014
Purpose: Methimazole is the most convenient drug used in the management of hyperthyroid patients. However, associated with its clinical use is hepatotoxicity as a life threatening adverse effect.
Reza Heidari, Hossein Babaei, Leila Roshangar, Mohammad Ali Eghbal   +3 more
doaj   +1 more source

Assessment of Risk Factors of Hepatotoxicity among Tuberculosis Patients

Pharmacology and Clinical Pharmacy Research, 2018
Tuberculosis is a devastating disease caused by Mycobacterium tuberculosis. If left untreated or not properly treated, it could lead to progressive tissue damage and even death. Short-term chemotherapy containing isoniazid, rifampicin.
Muhammad F. Wardhana, Tiana Milanda, Sri A. Sumiwi   +2 more
doaj   +1 more source