Results 31 to 40 of about 201,064 (349)

Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine [PDF]

Advanced Pharmaceutical Bulletin, 2014
Purpose: Methimazole is the most convenient drug used in the management of hyperthyroid patients. However, associated with its clinical use is hepatotoxicity as a life threatening adverse effect.
Reza Heidari, Hossein Babaei, Leila Roshangar, Mohammad Ali Eghbal   +3 more
doaj   +1 more source

Nevirapine- and efavirenz-associated hepatotoxicity under programmatic conditions in Kenya and Mozambique. [PDF]

, 2012
To describe the frequency, risk factors, and clinical signs and symptoms associated with hepatotoxicity (HT) in patients on nevirapine- or efavirenz-based antiretroviral therapy (ART), we conducted a retrospective cohort analysis of patients attending ...
Biot, M, Chu, K M, Ford, N P, Manzi, M, Rasschaert, F, Zachariah, R, Zuniga, I   +6 more
core   +2 more sources

Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update

Journal of Clinical and Translational Hepatology, 2016
Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional overdose of acetaminophen (APAP) has affected patients for decades, and involves the cornerstone metabolic pathways which take place in the microsomes within ...
Eric D. Yoon, A. Babar, M. Choudhary, M. Kutner, N. Pyrsopoulos   +4 more
semanticscholar   +1 more source

Application of iTRAQ-Based Quantitative Proteomics Approach to Identify Deregulated Proteins Associated with Liver Toxicity Induced by Polygonum Multiflorum in Rats

Cellular Physiology and Biochemistry, 2017
Background/Aims: Clinical reports on adverse reactions that result from Polygonum multiflorum (PM) and its preparations, especially regarding liver injury, have recently received widespread attention.
Longfei Lin, Hui Li, Hongmei Lin, Miao Zhang, Changhai Qu, Lei Yan, Xingbin Yin, Jian Ni   +7 more
doaj   +1 more source

Evaluation of factors affecting epidermal growth factor receptor tyrosine kinase inhibitor-induced hepatotoxicity in Japanese patients with non-small cell lung cancer: a two-center retrospective study

Journal of Pharmaceutical Health Care and Sciences, 2022
Background Gefitinib and erlotinib, are epidermal growth factor receptor tyrosine kinase inhibitors, and are currently recommended for non-small cell lung cancer stage IV in the elderly and in patients with decreased performance status in the Japanese ...
Hirofumi Nagai, Tsutomu Shimada, Yoshimitsu Takahashi, Mikako Nishikawa, Hiroyuki Tozuka, Yasuto Yamamoto, Osamu Niwa, Yutaka Takahara, Arimi Fujita, Katsuhiko Nagase, Kazuo Kasahara, Seiji Yano, Yoshimichi Sai   +12 more
doaj   +1 more source

Cyclosporin a hepatotoxicity in 66 renal allograft recipients [PDF]

, 1981
Liver functional abnormalities were seen in 13 (19.7%) of 66 recipients of cadaveric renal homografts treated with cyclosporin A and prednisone. However, such presumed hepatotoxicity was a minor problem in the use of cyclosporin A.
Iwatsuki, S, Klintmalm, GBG, Starzl, TE
core   +1 more source

Risk factors of severe hepatotoxicity among HIV-1 infected individuals initiated on highly active antiretroviral therapy in the Northwest Region of Cameroon

BMC Gastroenterology, 2022
Background Hepatotoxicity due to highly active antiretroviral therapy (HAART) has gained prominent attention since it can be affected by many factors.
Lem Edith Abongwa, Anthony Kebira Nyamache, Fokunang Charles, Judith Torimiro, Nshom Emmanuel, Irénée Domkam, Mbu Eyongetah, Beriyuy Jude, Fung Holgar Mua, Sama Bella, Tankou Colman Tamboh, Erna Charlene Moungang, Victorine Ngum, Paul Okemo   +13 more
doaj   +1 more source

Drug Hepatotoxicity: Environmental Factors [PDF]

, 2017
Drug-induced liver injury presents as various forms of acute and chronic liver disease. There is wide geographic variation in the most commonly implicated agents.
Chalasani, Naga P., Stine, Jonathan G.
core   +1 more source

Cardiovascular and hepatic toxicity of cocaine: potential beneficial effects of modulators of oxidative stress [PDF]

, 2015
Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with ...
Antonilli, Letizia, Badiani, Aldo, Grassi, Maria Caterina, Graziani, Manuela, Saso, Luciano, Togna, Anna Rita   +5 more
core   +8 more sources

Hepatotoxicity of immune checkpoint inhibitors: a Bayesian network meta-analysis

Hepatology Communications, 2023
Background:. This systematic review and network meta-analysis aimed to provide a complete hepatotoxicity profile, hepatotoxicity spectrum, and safety ranking of immune checkpoint inhibitor drugs for cancer treatment. Methods:.
Caiyun Zheng, Shunmin Huang, Meimei Lin, Baohui Hong, Ruping Ni, Hengfen Dai, Xiuqin Lin, Jing Yang   +7 more
doaj   +1 more source