Results 51 to 60 of about 104,266 (306)

Incidence, mortality, and risk factors of immunotherapy-associated hepatotoxicity: A nationwide hospitalization analysis

Liver Research, 2021
Background and aims: Anti-neoplastic immunotherapy has revolutionized cancer management; however, its safety profile with respect to liver-related injury remains largely unexplored.
Simcha Weissman, Saad Saleem, Sachit Sharma, Menashe Krupka, Faisal Inayat, Muhammad Aziz, James H. Tabibian   +6 more
doaj   +1 more source

Voriconazole-Induced Hepatotoxicity in a Patient with Pulmonary Aspergillosis: A Case Report

, 2023
Li Gu,1 Tao Ai,2 Ling Pang,1 Dong Xu,1 Han Wang3 1Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of ...
Ai T, Gu L, Pang L, Xu D, Wang H
core  

A four-month gatifloxacin-containing regimen for treating tuberculosis. [PDF]

, 2014
BACKGROUND: Shortening the course of treatment for tuberculosis would be a major improvement for case management and disease control. This phase 3 trial assessed the efficacy and safety of a 4-month gatifloxacin-containing regimen for treating rifampin ...
Horton, John, Lapujade, Olivier, Lapujade, O., Lienhardt, Christian, N'Diaye, Alimatou, Perronne, Christian, Odhiambo, Joseph, Amukoye, Evans, Olliaro, Piero L, Odhiambo, J., De Jong, B.C., Kassa, F., Olliaro, P.L., Horton, J., Bah Sow, O., Kassa, Ferdinand, Merle, Corinne S, Sismanidis, Charalambos, Bah, Boubacar, Gninafon, Martin, Merle, C.S., Gnignafon, M., Lo, Mame B, Bah, B., Rustomjee, Roxana, Lo, M.B., Fielding, K., Sismanidis, C., Mthiyane, T., Sow, Omou Bah, N'Diaye, A., Rustomjee, R., Fielding, Katherine, OFLOTUB/Gatifloxacin for Tuberculosis Project, de Jong, Bouke C, Amukoye, E., Mthiyane, Thuli, Perronne, C.   +37 more
core   +1 more source

Non‐Additive Criteria Assessment in Sustainability Evaluation of High Entropy Alloys: A Toxicity‐Weighted Framework

Advanced Engineering Materials, EarlyView.
Sustainability assessment requires methodologies that appropriately distinguish between additive and non‐additive material properties. A toxicity‐weighted scoring system is developed and applied that accounts for the disproportionate influence of highly toxic constituents through nonlinear weighting functions, providing more realistic estimates than ...
Seth Mehalic, Oladele A. Ogunseitan, Julie M. Schoenung   +2 more
wiley   +1 more source

Hepatotoxicity of New Oral Anticoagulants (NOACs)

, 2015
Case reports and analyses of clinical studies and of pharmacovigilance data suggest that new oral anticoagulants (NOACs) are associated with a small risk for hepatotoxicity.
Rätz Bravo, Alexandra E., Krähenbühl, Stephan, Liakoni, Evangelia, Rätz Bravo, Alexandra E   +3 more
core   +1 more source

Factors Influencing Imatinib-Induced Hepatotoxicity

, 2020
Purpose Although imatinib-induced hepatotoxicity may aggravate the patient's clinical condition and alter the treatment plan, the underlying mechanism of and factors influencing imatinib-induced hepatotoxicity have rarely been investigated ...
곽혜선
core   +1 more source

Eculizumab hepatotoxicity in pediatric aHUS. [PDF]

, 2015
BACKGROUND Eculizumab is a humanized anti-C5 antibody approved for the treatment of atypical hemolytic uremic syndrome (aHUS). Its use is increasing in children following reports of its safety and efficacy.
Hayes, Wesley, Tschumi, Sibylle, Feber, Janusz, Ling, Simon C, Licht, Christoph, Kirschfink, Michael   +5 more
core   +2 more sources

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Real-world data of Azvudine-induced hepatotoxicity among hospitalized COVID-19 patients in China: a retrospective case-control study

Frontiers in Pharmacology
BackgroundThe COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to global health crisis. Although several antiviral drugs have been used to mitigate the severity and mortality of COVID-19, the safety profile remained a critical concern. Azvudine,
Yuanguo Xiong, Hao Xin, Cai Shi, Xianxi Guo, Ying Chen, Caifei Huang, Fuwang Ma, Ge Yang, Jian Yang   +8 more
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source