Results 61 to 70 of about 104,266 (306)

Antituberculosis drugs and hepatotoxicity among hospitalized patients in Jos, Nigeria

International Journal of Mycobacteriology, 2016
Background: Tuberculosis (TB) could be fatal if left untreated, however, adverse effects of anti-TB medications (anti-TBs) themselves may limit treatment. We determined the incidence and clinical characteristics of hepatotoxicity in hospitalized patients
Samson E Isa, Augustine O Ebonyi, Nathan Y Shehu, Patrick Idoko, Joseph A Anejo-Okopi, Gomerep Simji, Rachael U Odesanya, Isaac O Abah, Hafsat O Jimoh   +8 more
doaj   +1 more source

A Combination of In Silico ADMET Prediction, In Vivo Toxicity Evaluation, and Potential Mechanism Exploration of Brucine and Brucine N-oxide—A Comparative Study

Molecules, 2023
Brucine (BRU) and brucine N-oxide (BNO) are prominent, bioactive, and toxic alkaloids in crude and processed Semen Strychni. Studies have demonstrated that BRU and BNO possess comprehensive pharmacological activities, such as anti-inflammatory and ...
Yan Gao, Lin Guo, Ying Han, Jingpu Zhang, Zhong Dai, Shuangcheng Ma   +5 more
doaj   +1 more source

Pharmacogenetics of isoniazid-induced hepatotoxicity [PDF]

, 2015
Tuberculosis is still a major problem in some developed and developing countries. The poor compliance to the treatment of tuberculosis patients due to the adverse events was supposed to be an important factor contributing to the high prevalence.
Wilffert, Bob, Perwitasari, Dyah Aryani, Atthobari, Jarir   +2 more
core   +2 more sources

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

EXPERIMENTAL MODELS FOR HEPATOTOXICITY [PDF]

, 2015
The liver is among the most complex and important organs in the human body. Hepatotoxicity is a leading cause of morbidity and mortality, and itsprevalence is continuously increasing day by day in the industrialized nations.
Singh, Gurfateh, Dhadwal, Nancy, Harikumar, S.l.   +2 more
core   +1 more source

Hepatotoxicity in patients with non-small cell lung cancer treated with sotorasib after prior immunotherapy: a comprehensive clinical and pharmacokinetic analysisResearch in context

EBioMedicine
Summary: Background: Sotorasib given after immunotherapy could put patients at increased risk of hepatotoxicity. Therefore, there is a need to gain insight into the potential correlation between anti-PD-(L)1 treatment, anti-PD-(L)1 concentrations ...
Sophie M. Ernst, Maaike M. Hofman, Tessa E. van der Horst, Marthe S. Paats, Frank W.J. Heijboer, Joachim G.J.V. Aerts, Daphne W. Dumoulin, Robin Cornelissen, Jan H. von der Thüsen, Peter de Bruijn, Esther Oomen-de Hoop, Ron H.J. Mathijssen, Stijn L.W. Koolen, Anne-Marie C. Dingemans   +13 more
doaj   +1 more source

The protective role of probiotics in the mitigation of carbon tetrachloride (CCl4) induced hepatotoxicity

Food Chemistry Advances, 2023
Carbon tetrachloride (CCl4) is one of the traditional hepatotoxicants. Chronic liver damage can result from long-term CCl4 treatment, which is also a well-known model for producing hepatotoxicity.
Tarun Kumar Dua, Gouhar Jahan Ashraf, Sangita Palai, Tania Baishya, Gouranga Nandi, Ranabir Sahu, Paramita Paul   +6 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Risks of hepatotoxicities during the intensive phase of tuberculosis treatment: A hospital-based case control study

Asian Pacific Journal of Tropical Medicine
Objective: To identify factors associated with hepatotoxicity during the intensive phase of treatment in tuberculosis (TB) patients. Methods: A case-control study was conducted of TB patients treated with first-line anti-TB drugs from 2013 to 2020. Cases
Khanaphan Kemmarak, Bhunyabhadh Chaimay, Somkiattiyos Woradet   +2 more
doaj   +1 more source