Results 81 to 90 of about 201,064 (349)

Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles

Particle and Fibre Toxicology, 2019
Due to its excellent physicochemical properties and wide applications in consumer goods, titanium dioxide nanoparticles (TiO2 NPs) have been increasingly exposed to the environment and the public.
Zhangjian Chen, Di Zhou, Shuo Han, Shupei Zhou, G. Jia   +4 more
semanticscholar   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Real-world data of Azvudine-induced hepatotoxicity among hospitalized COVID-19 patients in China: a retrospective case-control study

Frontiers in Pharmacology
BackgroundThe COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to global health crisis. Although several antiviral drugs have been used to mitigate the severity and mortality of COVID-19, the safety profile remained a critical concern. Azvudine,
Yuanguo Xiong, Hao Xin, Cai Shi, Xianxi Guo, Ying Chen, Caifei Huang, Fuwang Ma, Ge Yang, Jian Yang   +8 more
doaj   +1 more source

Antituberculosis drugs and hepatotoxicity among hospitalized patients in Jos, Nigeria

International Journal of Mycobacteriology, 2016
Background: Tuberculosis (TB) could be fatal if left untreated, however, adverse effects of anti-TB medications (anti-TBs) themselves may limit treatment. We determined the incidence and clinical characteristics of hepatotoxicity in hospitalized patients
Samson E Isa, Augustine O Ebonyi, Nathan Y Shehu, Patrick Idoko, Joseph A Anejo-Okopi, Gomerep Simji, Rachael U Odesanya, Isaac O Abah, Hafsat O Jimoh   +8 more
doaj   +1 more source

The protective role of probiotics in the mitigation of carbon tetrachloride (CCl4) induced hepatotoxicity

Food Chemistry Advances, 2023
Carbon tetrachloride (CCl4) is one of the traditional hepatotoxicants. Chronic liver damage can result from long-term CCl4 treatment, which is also a well-known model for producing hepatotoxicity.
Tarun Kumar Dua, Gouhar Jahan Ashraf, Sangita Palai, Tania Baishya, Gouranga Nandi, Ranabir Sahu, Paramita Paul   +6 more
doaj   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Hepatotoxicity in patients with non-small cell lung cancer treated with sotorasib after prior immunotherapy: a comprehensive clinical and pharmacokinetic analysisResearch in context

EBioMedicine
Summary: Background: Sotorasib given after immunotherapy could put patients at increased risk of hepatotoxicity. Therefore, there is a need to gain insight into the potential correlation between anti-PD-(L)1 treatment, anti-PD-(L)1 concentrations ...
Sophie M. Ernst, Maaike M. Hofman, Tessa E. van der Horst, Marthe S. Paats, Frank W.J. Heijboer, Joachim G.J.V. Aerts, Daphne W. Dumoulin, Robin Cornelissen, Jan H. von der Thüsen, Peter de Bruijn, Esther Oomen-de Hoop, Ron H.J. Mathijssen, Stijn L.W. Koolen, Anne-Marie C. Dingemans   +13 more
doaj   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

A Risk Scoring System Utilizing Machine Learning Methods for Hepatotoxicity Prediction One Year After the Initiation of Tyrosine Kinase Inhibitors

Frontiers in Oncology, 2022
BackgroundThere is currently no method to predict tyrosine kinase inhibitor (TKI) -induced hepatotoxicity. The purpose of this study was to propose a risk scoring system for hepatotoxicity induced within one year of TKI administration using machine ...
Ji Min Han, Jeong Yee, Soyeon Cho, Soyeon Cho, Min Kyoung Kim, Min Kyoung Kim, Jin Young Moon, Jin Young Moon, Dasom Jung, Dasom Jung, Jung Sun Kim, Jung Sun Kim, Hye Sun Gwak   +12 more
doaj   +1 more source

Methotrexate hepatotoxicity in patients with rheumatoid arthritis. [PDF]

, 2010
BACKGROUND Increases in aminotransferases (transaminitis) are potential major adverse reactions seen with long-term use of methotrexate (MTX). The aim of this study, therefore was to evaluate the incidence of MTX induced hepatotoxicity and its risk ...
Akhlaghi, M, Anvari, B, Kolahdoozan, S, Shahraeeni, S, Sotoudehmanesh, R   +4 more
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