Results 91 to 100 of about 104,266 (306)

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Liver Enzyme Abnormalities and Associated Risk Factors in HIV Patients on Efavirenz-Based HAART with or without Tuberculosis Co-Infection in Tanzania. [PDF]

, 2012
To investigate the timing, incidence, clinical presentation, pharmacokinetics and pharmacogenetic predictors for antiretroviral and anti-tuberculosis drug induced liver injury (DILI) in HIV patients with or without TB co-infection.
Ngaimisi, E., Klaus-Dieter Riedel, Janabi Mohamed, Bakari, Muhammad, Burhenne Juergen, Minzi, Omary, Eric Sandstrom, Mugusi Sabina, Sandstrom Eric, Mohamed Janabi, Omary Minzi, Mugusi Ferdinand, Bakari Muhammad, Burhenne, J., Eleni Aklillu, Muhammad Bakari, Lars Lindquist, Eliford Ngaimisi, Minzi Omary, Riedel Klaus-Dieter, Mugusi, Sabina, Riedel, Klaus-Dieter, Mugusi, F., Sandstrom, E., Juergen Burhenne, Aklillu, E., Riedel, K.D., Ngaimisi Eliford, Lindquist, Lars, Ferdinand Mugusi, Mugusi, Ferdinand, Burhenne, Juergen, Lindquist, L., Lindquist Lars, Mugusi, S., Janabi, Mohamed, Aklillu, Eleni, Aklillu Eleni, Sandstrom, Eric, Sabina Mugusi, Janabi, M., Minzi, O., Bakari, M., Ngaimisi, Eliford   +43 more
core   +2 more sources

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Real-world pharmacovigilance assessment of hepatotoxicity risk with HER2-Targeted drugs using FAERS database analysis

Scientific Reports
Human epidermal growth factor receptor 2 (HER2)-targeted therapies, including monoclonal antibodies (mAbs), small-molecule tyrosine kinase inhibitors (TKIs), and antibody-drug conjugates (ADCs), have significantly improved clinical outcomes in HER2 ...
Junli Dong, Dan Chen, Minyu Zhong, Guangyi Yu   +3 more
doaj   +1 more source

Three-Level Hepatotoxicity Prediction System Based on Adverse Hepatic Effects

, 2018
Hepatotoxicity is a major cause of drug withdrawal from the market. To reduce the drug attrition induced by hepatotoxicity, an accurate and efficient hepatotoxicity prediction system must be constructed. In the present study, we constructed a three-level
Zhen-Ke Deng (6086921), Dong-Sheng Cao (399743), Yan Cheng (149222), Lin Zhang, Defang Ouyang, Qian Cao, Hui Wei, Zhen-Ke Deng, Qian Cao (198055), Li Fu, Lu Liu, Wen-Ling Ye (6086918), Defang Ouyang (2283385), Lu Liu (171341), Li Fu (85791), Jin-Wei Zhang (2344564), Jin-Wei Zhang, Yan Cheng, Lin Zhang (8926), Wen-Ling Ye, Dong-Sheng Cao, Hui Wei (126971)   +21 more
core   +1 more source

Molecular Mechanisms of Hepatotoxicity

, 2023
Drug-induced liver injury, also known as drug-induced hepatotoxicity (DILI), is a major cause of medicine withdrawal (prescription or over-the-counter) from the market [...
Antonietta Messina, Jean-Charles Duclos-Vallée   +1 more
core   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Hepatotoxicity of Chemotherapy

The Oncologist, 2001
Abstract After assessment of tumor histology, the next important factor to consider in the selection of a chemotherapy regime is organ function. Patients who are to receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs may not be appropriate, and which drug doses should be modified.
P D, King, M C, Perry
openaire   +2 more sources

NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]

, 2014
The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Teemu P. Miettinen, Mikael Björklund, Miettinen, Teemu P., Björklund, Mikael   +3 more
core   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source