Results 101 to 110 of about 201,064 (349)

Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia

BMC Research Notes, 2020
Objectives Anti-tuberculosis drug-induced hepatotoxicity is a common serious adverse drug reaction. This study intended to determine the prevalence and associated factors of drug-induced hepatotoxicity among tuberculosis and human immunodeficiency virus ...
Abebe Zeleke, Bethelihem Misiker, Teshager Aklilu Yesuf   +2 more
doaj   +1 more source

Pulse-Administered Toceranib Phosphate Plus Lomustine for Treatment of Unresectable Mast Cell Tumors in Dogs. [PDF]

, 2015
BackgroundNonresectable mast cell tumors (MCT) in dogs remain a therapeutic challenge, and investigation of novel combination therapies is warranted. Intermittent administration of tyrosine kinase inhibitors (TKI) combined with cytotoxic chemotherapy may
Avery, AC, Axiak-Bechtel, SM, Burton, JH, Clifford, CA, Thamm, DH, Vail, DM, Venable, RO, Williams, LE   +7 more
core   +1 more source

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

Toxicological Sciences, 2018
High failure rates of drug candidates in the clinics, restricted-use warnings as well as withdrawals of drugs in postmarketing stages are of substantial concern for the pharmaceutical industry and drug-induced liver injury (DILI) constitutes one of the ...
Sabine U. Vorrink, Yitian Zhou, M. Ingelman-Sundberg, V. M. Lauschke   +3 more
semanticscholar   +1 more source

Serum Bile Acids Are Useful Indicators of Intrahepatic Recurrence After Initial Curative Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Bile acids accumulation in hepatocytes causes liver damage and contributes to the development of hepatocellular carcinoma. However, the association between serum bile acid levels and postoperative intrahepatic recurrence in hepatocellular carcinoma remains unclear.
Tomoaki Bekki, Masahiro Ohira, Yuki Imaoka, Seiichi Simizu, Tomoyuki Abe, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Hideki Ohdan   +9 more
wiley   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. [PDF]

, 2017
Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol and toxin metabolism by catalyzing the conversion of substrates into more polar metabolites and producing reactive oxygen species.
Brenner, David A, Davidson, Nicholas O, Dennis, Edward A, Hu, Ronglin, Karin, Gabriel, Kisseleva, Tatiana, Koyama, Yukinori, Liang, Shuang, Ma, Hsiao-Yen, Quehenberger, Oswald, Sun, Mengxi, Xu, Jun   +11 more
core   +1 more source

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Archives of Toxicology, 2013
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes ...
P. Godoy, N. Hewitt, U. Albrecht, M. Andersen, Nariman Ansari, S. Bhattacharya, J. Bode, J. Bolleyn, C. Borner, J. Böttger, A. Braeuning, R. Budinsky, B. Burkhardt, N. Cameron, G. Camussi, C. Cho, Yun-Jaie Choi, J. Craig Rowlands, U. Dahmen, G. Damm, O. Dirsch, M. Donato, Jian Dong, S. Dooley, D. Drasdo, R. Eakins, Karine Ferreira, V. Fonsato, J. Fraczek, R. Gebhardt, Andrew Gibson, M. Glanemann, C. Goldring, M. Gómez‐Lechón, G. Groothuis, L. Gustavsson, C. Guyot, D. Hallifax, S. Hammad, Adam S. Hayward, D. Häussinger, C. Hellerbrand, P. Hewitt, S. Hoehme, H. Holzhütter, J. Houston, Jens Hrach, Kiyomi Ito, H. Jaeschke, V. Keitel, J. Kelm, B. Kevin Park, C. Kordes, G. Kullak-Ublick, E. LeCluyse, Peng Lu, Jennifer Luebke‐Wheeler, Anna Lutz, Daniel J. Maltman, M. Matz-Soja, P. McMullen, I. Merfort, S. Messner, C. Meyer, J. Mwinyi, D. Naisbitt, A. Nussler, P. Olinga, F. Pampaloni, J. Pi, L. Pluta, S. Przyborski, A. Ramachandran, V. Rogiers, C. Rowe, C. Schelcher, Kathrin Schmich, M. Schwarz, Bijay Singh, E. Stelzer, B. Stieger, Regina M. Stöber, Y. Sugiyama, C. Tetta, W. Thasler, T. Vanhaecke, M. Vinken, T. Weiss, Agata Widera, C. Woods, J. Xu, Kathy M. Yarborough, J. Hengstler   +92 more
semanticscholar   +1 more source

Pharmacological evaluation of Adenostemma lavenia acetone extract in Swiss Albino mice: Analgesic, anti‐inflammatory, and thrombolytic insights from in vivo, in vitro, density functional theory, and molecular docking studies

Animal Models and Experimental Medicine, EarlyView.
Adenostemma lavenia, a traditionally used medicinal plant, has been employed to manage pain, inflammation, and circulatory issues. This study investigates the analgesic, anti‐inflammatory, and thrombolytic potentials of the acetone extract of A. lavenia leaves (AEAL) using in vivo, in vitro, and in silico methods.
Nusrat Jahan Moon, Mahathir Mohammad, Md. Jahirul Islam Mamun, Fahmina Binty Azim Nova, Nazmul Hasan Eshaque, Md. Hossain Rasel, Zobayed Islam, Md. Mahmudul Hasan, Md. Liakot Ali, Md. Tanvir Chowdhury, S. M. Moazzem Hossen   +10 more
wiley   +1 more source

Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIV/HCV Coinfected Patients

AIDS Research and Treatment, 2010
Introduction. Hepatotoxicity is a concern in HIV/hepatitis C virus (HCV) coinfected patients due to their underlying liver disease. This study assessed the incidence of hepatotoxicity in HIV/HCV co-infected patients in two outpatient infectious diseases ...
Emily L. Heil, Mary L. Townsend, Kenneth Shipp, Amy Clarke, Melissa D. Johnson   +4 more
doaj   +1 more source

NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]

, 2014
[Image: see text] The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Ahn K. S., Andersson D. A., Antoine M., Bajt M. L., Bantscheff M., Bessems J. G., Buryanovskyy L., Celli C. M., Cheung C., Chung C. W., Cohen S. D., Cover C., Dahlin D. C., Forman H. J., Fu Y., Graham G. G., Graves P. R., Jaeschke H., James L. P., James L. P., Janbaz K. H., Kheradpezhouh E., Knight T. R., Knox R. J., Laukkanen M. O., Liao S., Lister C. F., Long D. J., Manyike P. T., Martinez Molina D., McGill M. R., Miettinen T. P., Mikael Björklund, Moore M., Moynihan R., Niesen F. H., Nosjean O., Reybier K., Sener G., Shah A. D., Shuhendler A. J., Teemu P. Miettinen, Tirmenstein M. A., Tripathy D., Vella F., Winger J. A.   +45 more
core   +4 more sources