Results 1 to 10 of about 128,609 (301)

Use of Arctium lappa Extract Against Acetaminophen-Induced Hepatotoxicity in Rats [PDF]

Current Therapeutic Research, 2015
Background: Severe destructive hepatic injuries can be induced by acetaminophen overdose and may lead to acute hepatic failure. Objective: To investigate the ameliorative effects of Arctium lappa root extract on acetaminophen-induced hepatotoxicity ...
Attalla Farag El-Kott, PhD, Mashael Mohammed Bin-Meferij, PhD   +1 more
doaj   +6 more sources

Acetaminophen-cysteine adducts during therapeutic dosing and following overdose [PDF]

BMC Gastroenterology, 2011
Background Acetaminophen-cysteine adducts (APAP-CYS) are a specific biomarker of acetaminophen exposure. APAP-CYS concentrations have been described in the setting of acute overdose, and a concentration >1.1 nmol/ml has been suggested as a marker of ...
Judge Bryan S, James Laura P, Green Jody L, Heard Kennon J, Zolot Liza, Rhyee Sean, Dart Richard C   +6 more
doaj   +4 more sources

Acetaminophen Toxicity [PDF]

Journal of education & teaching in emergency medicine
This is a practice structured interview case which is appropriate for emergency medicine residents at all levels of training.Acetaminophen (APAP) is an over-the-counter medication commonly used by adult and pediatric populations. While acetaminophen has demonstrated to be reasonably safe and well-tolerated at therapeutic doses, it can cause severe ...
Schaffer DH, Murray BP, Khazaeni B.
europepmc   +3 more sources

Chemical stability and compatibility of acetaminophen injection with six common opioid drugs: implications for clinical use [PDF]

Brazilian Journal of Medical and Biological Research
Despite the clinical importance of combining acetaminophen and opioids in multimodal analgesia, their compatibility has not been determined. This study aimed to investigate the stability and feasibility of mixing acetaminophen injection with six commonly
Weilin Huang, Shuyang He, Miao Zhao, Shunyuan Hong, Junhong Xu, Limin Chen, Xianping Wu   +6 more
doaj   +3 more sources

Effect of perioperative acetaminophen on body temperature after cardiovascular surgery with cardiopulmonary bypass: A single-center retrospective study

Annals of Cardiac Anaesthesia, 2021
Context: Postoperative hyperthermia, which may lead to cognitive decline, is a common complication of cardiovascular surgery with cardiopulmonary bypass (CPB).
Shohei Kaneko, Taiga Ichinomiya, Shuntaro Sato, Motohiro Sekino, Hiroaki Murata, Tetsuya Hara   +5 more
doaj   +1 more source

Acute effects of acetaminophen on the developmental, swimming performance and cardiovascular activities of the African catfish embryos/larvae (Clarias gariepinus)

Ecotoxicology and Environmental Safety, 2021
Acetaminophen is a widely used analgesic that has been detected in many water bodies with few reports concerning its potential toxicity to fish. This study sought to assess the developmental, swimming performance and cardiovascular activities of embryo ...
Nosakhare Osazee Erhunmwunse, Isioma Tongo, Lawrence Ikechukwu Ezemonye   +2 more
doaj   +1 more source

Acetaminophen-induced hypotension in sepsis

Journal of Pharmaceutical Health Care and Sciences, 2022
Background Acetaminophen-induced hypotension has been reported in critically ill patients; however, it remains unclear whether mannitol, present as a stabilizing compound in acetaminophen formulations, affects hemodynamic changes.
Shunsuke Inage, Ryo Yajima, Shintaro Nagahara, Aya Kazama, Moe Takamura, Tomohiro Shoji, Mika Kadoi, Yukiko Tashiro, Yuya Ise   +8 more
doaj   +1 more source

Macrophage migration inhibitory factor as a potential biomarker in acetaminophen overdose: a pilot study

Toxicology Communications, 2022
Acetaminophen overdose is a leading cause of liver failure in the United States. Macrophage migration inhibitory factor (MIF) is a cytokine that is released early and promotes acetaminophen toxicity in preclinical models.
Joshua Bloom, Teddy Uzamere, Yasmin Hurd, Alex F. Manini   +3 more
doaj   +1 more source

Delayed Acetaminophen Absorption Resulting in Acute Liver Failure

Case Reports in Critical Care, 2022
Introduction. Acetaminophen is a common medication involved in deliberate and accidental self-poisoning. The acetaminophen treatment nomogram is used to guide acetylcysteine treatment.
Huiling Tan, Paul Stathakis, Benoj Varghese, Nicholas A. Buckley, Angela L. Chiew   +4 more
doaj   +1 more source

NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]

, 2014
[Image: see text] The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Ahn K. S., Andersson D. A., Antoine M., Bajt M. L., Bantscheff M., Bessems J. G., Buryanovskyy L., Celli C. M., Cheung C., Chung C. W., Cohen S. D., Cover C., Dahlin D. C., Forman H. J., Fu Y., Graham G. G., Graves P. R., Jaeschke H., James L. P., James L. P., Janbaz K. H., Kheradpezhouh E., Knight T. R., Knox R. J., Laukkanen M. O., Liao S., Lister C. F., Long D. J., Manyike P. T., Martinez Molina D., McGill M. R., Miettinen T. P., Mikael Björklund, Moore M., Moynihan R., Niesen F. H., Nosjean O., Reybier K., Sener G., Shah A. D., Shuhendler A. J., Teemu P. Miettinen, Tirmenstein M. A., Tripathy D., Vella F., Winger J. A.   +45 more
core   +4 more sources