Results 1 to 10 of about 90,535 (162)

The Dangers of Acetaminophen for Neurodevelopment Outweigh Scant Evidence for Long-Term Benefits

Children, 2023
Based on available data that include approximately 20 lines of evidence from studies in laboratory animal models, observations in humans, correlations in time, and pharmacological/toxicological considerations, it has been concluded without reasonable ...
William Parker, Lauren G. Anderson, John P. Jones, Rachel Anderson, Lauren Williamson, Dillan Bono-Lunn, Zacharoula Konsoula   +6 more
doaj   +1 more source

Effect of Piperine Pretreatment on Biochemical Profiles of Acetaminophen-Induced Hepatotoxicity in Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2012
BACKGROUND AND OBJECTIVE: Acetaminophen overdose is the most frequent cause of liver injuries. N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of acetaminophen induced by cytochrome P-450.
MT Kazemi, M Pour Nasrollah, MM Rezaei,, GH.A Jorsaraei, GH Maliji, S Kazemi, E Zabihi,, M Pouramir,, AA Moghadamnia   +8 more
doaj  

Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones

EBioMedicine, 2018
Background: Acetaminophen (paracetamol) is one of the most common medications used for management of pain in the world. There is lack of consensus about the mechanism of action, and concern about the possibility of adverse effects on reproductive health.
Isaac V. Cohen, Elizabeth T. Cirulli, Matthew W. Mitchell, Thomas J. Jonsson, James Yu, Naisha Shah, Tim D. Spector, Lining Guo, J. Craig Venter, Amalio Telenti   +9 more
doaj   +1 more source

Evaluating the Role of Susceptibility Inducing Cofactors and of Acetaminophen in the Etiology of Autism Spectrum Disorder

Life
More than 20 previously reported lines of independent evidence from clinical observations, studies in laboratory animal models, pharmacokinetic considerations, and numerous temporal and spatial associations indicate that numerous genetic and ...
John P. Jones, Lauren Williamson, Zacharoula Konsoula, Rachel Anderson, Kathryn J. Reissner, William Parker   +5 more
doaj   +1 more source

Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose.

PLoS ONE, 2020
Acetaminophen is one of the most common over-the-counter pain medications used worldwide and is considered safe at therapeutic dose. However, intentional and unintentional overdose accounts for up to 70% of acute liver failure cases in the western world.
Sarah Piel, Imen Chamkha, Adam Kozak Dehlin, Johannes K Ehinger, Fredrik Sjövall, Eskil Elmér, Magnus J Hansson   +6 more
doaj   +1 more source

Therapeutic doses of acetaminophen with co-administration of cysteine and mannitol during early development result in long term behavioral changes in laboratory rats.

PLoS ONE, 2021
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.
Navneet Suda, Jasmine Cendejas Hernandez, John Poulton, John P Jones, Zacharoula Konsoula, Caroline Smith, William Parker   +6 more
doaj   +1 more source

Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats

Open Veterinary Journal
Background: Acetaminophen has an antipyretic activity by inhibiting prostaglandin synthesis found in the brain, and this action is responsible for its analgesic effect, but overdose can cause hepatic and renal toxicity.
Iman Hussein Naser, Zahraa Abed al-Kareem, Moayad Mijbil Ubaid, Shatha Hussein Kadhim   +3 more
doaj   +1 more source

Postnatal Acetaminophen and Potential Risk of Autism Spectrum Disorder among Males

Behavioral Sciences, 2020
Some evidence from the literature suggests that postnatal acetaminophen exposure may be associated with increased risk of autism spectrum disorder (ASD). Using a data set obtained from a previous study that was derived from an Internet-based survey among
Seth S. Bittker, Kathleen R. Bell
doaj   +1 more source

Oxidative stress mediates end-organ damage in a novel model of acetaminophen-toxicity in Drosophila

Scientific Reports, 2022
Acetaminophen is the most common cause of acute drug-induced liver injury in the United States. However, research into the mechanisms of acetaminophen toxicity and the development of novel therapeutics is hampered by the lack of robust, reproducible, and
Bejan J. Saeedi, Sarah Hunter-Chang, Liping Luo, Kaiyan Li, Ken H. Liu, Brian S. Robinson   +5 more
doaj   +1 more source

The Electrochemical Properties of Acetaminophen on Bare Glassy Carbon Electrode

International Journal of Electrochemical Science, 2012
We have reported the modification of acetaminophen polymer films with chitosan. In this paper, the electrochemical oxidation of acetaminophen in different pHs and conditions at the bare glassy carbon electrode.
Ying Li, Shen-Ming Chen
doaj   +1 more source