Results 21 to 30 of about 82,013 (311)

Evaluation of miR-122 to Predict High Dose Acetaminophen-Induced Liver Injury in Mice: The Combination Uses of 5-Fluorouracil [PDF]

, 2018
Administration of high doses of acetaminophen (APAP) is known to cause drug-induced liver injury (DILI) in humans. Therefore, the detection or prediction of these side-effects at an early stage using appropriate biomarkers is the need of the hour.
Haraguchi, Ayana, Sasaki, Hitoshi, Munakata, Chie, Fuchigami, Yuki, Kodama, Yukinobu, Enomoto, Hatsune, Hagimori, Masayori, Hiroishi, Shu, Tachiki, Hidehisa, Kawakami, Shigeru   +9 more
core   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Acetaminophen for osteoarthritis

Cochrane Database of Systematic Reviews, 2006
Osteoarthritis (OA) is the most common form of arthritis. Published guidelines and expert opinion are divided over the relative role of acetaminophen (also called paracetamol or Tylenol) and non-steroidal anti-inflammatory drugs (NSAIDs) as first-line pharmacologic therapy.
T E, Towheed, L, Maxwell, M G, Judd, M, Catton, M C, Hochberg, G, Wells   +5 more
openaire   +3 more sources

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis

Kidney Research and Clinical Practice, 2020
Background : : Acetaminophen is commonly used for the relief of pain and fever. Advocacy organizations recommend acetaminophen as the drug of choice in patients with kidney disease.
Sukrit Kanchanasurakit, Aimusa Arsu, Wuttikorn Siriplabpla, Acharaporn Duangjai, Surasak Saokaew   +4 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Acetaminophen-cysteine adducts during therapeutic dosing and following overdose

BMC Gastroenterology, 2011
Background Acetaminophen-cysteine adducts (APAP-CYS) are a specific biomarker of acetaminophen exposure. APAP-CYS concentrations have been described in the setting of acute overdose, and a concentration >1.1 nmol/ml has been suggested as a marker of ...
Judge Bryan S, James Laura P, Green Jody L, Heard Kennon J, Zolot Liza, Rhyee Sean, Dart Richard C   +6 more
doaj   +1 more source

Conjugation of nitrated acetaminophen to Der p1 amplifies peripheral blood monocyte response to Der p1.

PLoS ONE, 2017
BACKGROUND:An association of acetaminophen use and asthma was observed in the International Study of Asthma and Allergies in Childhood study. However there are no clear mechanisms to explain an association between acetaminophen use and immunologic ...
Ryan G Thomas, Brenda M Rivera Reyes, Benjamin M Gaston, Nelki B Rivera Acosta, Ilya R Bederman, Laura A Smith, Morgan T Sutton, Benlian Wang, John F Hunt, Tracey L Bonfield   +9 more
doaj   +1 more source

Adverse effect profile comparison of pain regimens with and without intravenous acetaminophen in total hip and knee arthroplasty patients

SAGE Open Medicine, 2017
Background: The use of adjunct, non-opioid agents is integral for pain control following total hip and knee arthroplasty. Literature comparing safety profiles of intravenous acetaminophen versus opioids is lacking.
Alyssa Gallipani, A Scott Mathis, Hoytin Lee Ghin, Germin Fahim   +3 more
doaj   +1 more source

Using a decision tree algorithm to distinguish between repeated supra-therapeutic and acute acetaminophen exposures

BMC Medical Informatics and Decision Making, 2023
Background This study aimed to compare clinical and laboratory characteristics of supra-therapeutic (RSTI) and acute acetaminophen exposures using a predictive decision tree (DT) algorithm.
Omid Mehrpour, Christopher Hoyte, Samaneh Nakhaee, Bruno Megarbane, Foster Goss   +4 more
doaj   +1 more source