Results 11 to 20 of about 128,609 (301)

Effect of Saffron (Crocus sativus L.), as a Bioenhancer, on Pharmacokinetic of Acetaminophen: An Animal Study

open access: yesTraditional and Integrative Medicine, 2023
In Traditional Persian Medicine (TPM) saffron is used as an accompaniment agent “Mobadreq” in poly herbal formulations. According to TPM texts, “Mobadreq” is a substance (or drug) which facilitates access of drugs or food to the whole body or specific ...
Seyede Nargess Sadati Lamardi   +5 more
doaj   +1 more source

An evaluation on consumers' usage pattern of acetaminophen (paracetamol): A multicenter study from Penang, Malaysia

open access: yesArchives of Pharmacy Practice, 2017
Background: Acetaminophen poisoning is becoming an increasingly common social problem in Malaysia. An understanding of consumers' usage pattern of acetaminophen is essential in addressing the issue of accidental acetaminophen poisoning.
Chee Ping Chong   +2 more
doaj   +1 more source

Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure [PDF]

open access: yes, 2015
Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, are ...
A O'Riordan   +60 more
core   +7 more sources

Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity.

open access: yesPLoS ONE, 2015
Metabolomics approaches have enabled the study of new mechanisms of liver injury in experimental models of drug toxicity. Disruption of bile acid homeostasis is a known mechanism of drug induced liver injury.
Laura James   +8 more
doaj   +1 more source

Bananas decrease acetaminophen potency in in vitro assays. [PDF]

open access: yesPLoS ONE, 2018
Edible portions of bananas contain high levels of polyphenol oxidase, which catalyzes reactions in the melanin formation pathway. Tyrosine, a physiological substrate of polyphenol oxidase, has an analogous structure to acetaminophen.
Yoshihiro Uesawa, Naotaka Tsuji
doaj   +1 more source

False positive acetaminophen concentrations in icteric serum

open access: yesPractical Laboratory Medicine, 2016
Introduction: Serum concentrations of acetaminophen are measured to predict the risk of hepatotoxicity in cases of acetaminophen overdose and to identify acetaminophen use in patients with acute liver injury without a known cause.
L. de Jong   +4 more
doaj   +1 more source

Emergency Department Pain Management Following Implementation of a Geriatric Hip Fracture Program [PDF]

open access: yes, 2017
Introduction: Over 300,000 patients in the United States sustain low-trauma fragility hip fractures annually. Multidisciplinary geriatric fracture programs (GFP) including early, multimodal pain management reduce morbidity and mortality. Our overall goal
Casey, Scott D   +6 more
core   +4 more sources

Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis

open access: yesWestern Journal of Emergency Medicine, 2018
Introduction: Rhabdomyolysis and delayed acetaminophen hepatotoxicity may be associated with elevated serum transaminase values. Establishing the cause of elevated transaminases may be especially difficult because of limited or inaccurate histories of ...
Joshua B. Radke   +6 more
doaj   +1 more source

Acetaminophen overdose associated with double serum concentration peaks [PDF]

open access: yesJournal of Community Hospital Internal Medicine Perspectives, 2015
Acetaminophen is the most commonly used analgesic–antipyretic medication in the United States. Acetaminophen overdose, a frequent cause of drug toxicity, has been recognized as the leading cause of fatal and non-fatal hepatic necrosis.
Cristian Papazoglu   +4 more
doaj   +1 more source

Acetaminophen Hepatotoxicity [PDF]

open access: yesSeminars in Liver Disease, 2019
AbstractAcetaminophen (APAP) is one of the most popular and safe pain medications worldwide. However, due to its wide availability, it is frequently implicated in intentional or unintentional overdoses where it can cause severe liver injury and even acute liver failure (ALF).
Anup, Ramachandran, Hartmut, Jaeschke
openaire   +2 more sources

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