Results 31 to 40 of about 90,535 (162)

Comparison of N-Acetyl Cysteine and Resveratrol Treatments in Acetaminophen Toxicity Model in Rabbits

Ahi Evran Medical Journal, 2022
Purpose: Acetaminophen is safe analgesic drug but it may cause hepatic failure in high doses. N-acetyl cysteine (NAC) is used in the treatment of acetaminophen intoxication.
Hasan Gazi UYAR, Aysegül BAYIR, Hasan KARA, Pınar KARABAĞLI, Abdullah SİVRİKAYA, Ali UNLU   +5 more
doaj   +1 more source

Acetaminophen-cysteine adducts during therapeutic dosing and following overdose

BMC Gastroenterology, 2011
Background Acetaminophen-cysteine adducts (APAP-CYS) are a specific biomarker of acetaminophen exposure. APAP-CYS concentrations have been described in the setting of acute overdose, and a concentration >1.1 nmol/ml has been suggested as a marker of ...
Judge Bryan S, James Laura P, Green Jody L, Heard Kennon J, Zolot Liza, Rhyee Sean, Dart Richard C   +6 more
doaj   +1 more source

Conjugation of nitrated acetaminophen to Der p1 amplifies peripheral blood monocyte response to Der p1.

PLoS ONE, 2017
BACKGROUND:An association of acetaminophen use and asthma was observed in the International Study of Asthma and Allergies in Childhood study. However there are no clear mechanisms to explain an association between acetaminophen use and immunologic ...
Ryan G Thomas, Brenda M Rivera Reyes, Benjamin M Gaston, Nelki B Rivera Acosta, Ilya R Bederman, Laura A Smith, Morgan T Sutton, Benlian Wang, John F Hunt, Tracey L Bonfield   +9 more
doaj   +1 more source

Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis

Kidney Research and Clinical Practice, 2020
Background : : Acetaminophen is commonly used for the relief of pain and fever. Advocacy organizations recommend acetaminophen as the drug of choice in patients with kidney disease.
Sukrit Kanchanasurakit, Aimusa Arsu, Wuttikorn Siriplabpla, Acharaporn Duangjai, Surasak Saokaew   +4 more
doaj   +1 more source

Adverse effect profile comparison of pain regimens with and without intravenous acetaminophen in total hip and knee arthroplasty patients

SAGE Open Medicine, 2017
Background: The use of adjunct, non-opioid agents is integral for pain control following total hip and knee arthroplasty. Literature comparing safety profiles of intravenous acetaminophen versus opioids is lacking.
Alyssa Gallipani, A Scott Mathis, Hoytin Lee Ghin, Germin Fahim   +3 more
doaj   +1 more source

Acetaminophen hepatotoxicity: an updated review [PDF]

, 2015
As the most common cause of acute liver failure (ALF) in the USA and UK, acetaminophen-induced hepatotoxicity remains a significant public health concern and common indication for emergent liver transplantation.
Lancaster, Elizabeth M, Hiatt, Jonathan R, Zarrinpar, Ali   +2 more
core   +1 more source

Acetaminophen Use Concomitant with Long-Lasting Flucloxacillin Therapy: A Dangerous Combination

European Journal of Case Reports in Internal Medicine, 2020
Acetaminophen and flucloxacillin both interfere with the ?-glutamyl cycle. Long-lasting concomitant use of flucloxacillin and acetaminophen can lead to 5-oxoproline accumulation and severe high anion gap metabolic acidosis.
Luuk René van den Bersselaar, Judith Maria Dimphena van den Brule, Johannes Gerardus van der Hoeven   +2 more
doaj   +1 more source

Using a decision tree algorithm to distinguish between repeated supra-therapeutic and acute acetaminophen exposures

BMC Medical Informatics and Decision Making, 2023
Background This study aimed to compare clinical and laboratory characteristics of supra-therapeutic (RSTI) and acute acetaminophen exposures using a predictive decision tree (DT) algorithm.
Omid Mehrpour, Christopher Hoyte, Samaneh Nakhaee, Bruno Megarbane, Foster Goss   +4 more
doaj   +1 more source

On the safety of acetaminophen [PDF]

, 2022
Acetaminophen is one of the most commonly used analgesics /anti pyretics. However, taking into account the existing risk of hepatotoxicity,regulatory bodies of a number of the countries made additional adjustments tothe recommendations on the use of this
V. K. Lepakhin, R. N. Alyautdin, A. P. Pereverzev, B. K. Romanov   +3 more
core  

Interaction of Aldehyde dehydrogenase with acetaminophen as examined by spectroscopies and molecular docking

Biochemistry and Biophysics Reports, 2017
The interaction of acetaminophen, a non-substrate anionic ligand, with Aldehyde Dehydrogenase was studied by fluorescence, UV–Vis absorption, and circular dichroism spectroscopies under simulated physiological conditions.
Ayodele O. Kolawole
doaj   +1 more source