Results 31 to 40 of about 88,369 (298)

Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease

Clinical and Translational Science, 2019
Four complementary approaches were used to investigate acetaminophen overdose as a risk factor for Parkinson's disease (PD). Circulating microRNAs (miRNAs) serum profiles from acetaminophen‐overdosed patients were compared with patients with terminal PD,
Sacha Bohler, Xiaosong Liu, Julian Krauskopf, Florian Caiment, Jiri Aubrecht, Gerry A. F. Nicolaes, Jos C. S. Kleinjans, Jacco J. Briedé   +7 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Electro‐Organic Synthesis at a Stable Oil/Water/Solid Three‐Phase Interface Reactor

Angewandte Chemie, EarlyView.
A porous membrane electrode (PME) reactor is developed to promote oil/water/solid three‐phase interfacial contact for electro‐organic synthesis. By promoting the formation of an oil/water interfacial region within or near an amphiphilic catalytic layer, the reactor enables efficient conversion of water‐insoluble organic reactants in aqueous ...
Deyin Chen, Jianan Zhu, Huan Wu, Huajun Zheng, Longhao Jiao, Chengpu Chu, Yinghua Xu, Bin Liu   +7 more
wiley   +2 more sources

Interaction of Aldehyde dehydrogenase with acetaminophen as examined by spectroscopies and molecular docking

Biochemistry and Biophysics Reports, 2017
The interaction of acetaminophen, a non-substrate anionic ligand, with Aldehyde Dehydrogenase was studied by fluorescence, UV–Vis absorption, and circular dichroism spectroscopies under simulated physiological conditions.
Ayodele O. Kolawole
doaj   +1 more source

Public awareness of acetaminophen and risks of drug induced liver injury: Results of a large outpatient clinic survey.

PLoS ONE, 2020
Acetaminophen is one of the most commonly consumed analgesics world wide. Generally perceived as a safe medication, it is the most common cause of acute liver failure in the United States with inadvertent hepatotoxicity in half of all cases. We therefore
Robert A Mitchell, Sahaj Rathi, Monica Dahiya, Julie Zhu, Trana Hussaini, Eric M Yoshida   +5 more
doaj   +1 more source

Acetaminophen Use Concomitant with Long-Lasting Flucloxacillin Therapy: A Dangerous Combination

European Journal of Case Reports in Internal Medicine, 2020
Acetaminophen and flucloxacillin both interfere with the ?-glutamyl cycle. Long-lasting concomitant use of flucloxacillin and acetaminophen can lead to 5-oxoproline accumulation and severe high anion gap metabolic acidosis.
Luuk René van den Bersselaar, Judith Maria Dimphena van den Brule, Johannes Gerardus van der Hoeven   +2 more
doaj   +1 more source

Pharmacist and Physician Interpretation of Abbreviations for Acetaminophen Intended for Use in a Consumer Icon

Pharmacy, 2015
Concomitant use of multiple acetaminophen medications is associated with overdose. To help patients identify acetaminophen medications and thus avoid concomitant use, an icon with an abbreviation for “acetaminophen” has been proposed for all ...
Saul Shiffman, Helene Cotton, Christina Jessurun, Mark A. Sembower, Steve Pype, Jerry Phillips   +5 more
doaj   +1 more source

Intravenous vs oral acetaminophen in sinus surgery: A randomized clinical trial

Laryngoscope Investigative Otolaryngology, 2020
Background Multimodal perioperative analgesia including acetaminophen is recommended by current guidelines. The comparative efficacy of intravenous vs oral acetaminophen in sinus surgery is unknown.
Ravi Bhoja, Matthew W. Ryan, Kevin Klein, Abu Minhajuddin, Emily Melikman, Mohamed Hamza, Bradley F. Marple, David L. McDonagh   +7 more
doaj   +1 more source