Results 51 to 60 of about 82,016 (264)
The Dangers of Acetaminophen for Neurodevelopment Outweigh Scant Evidence for Long-Term Benefits
Children, 2023 Based on available data that include approximately 20 lines of evidence from studies in laboratory animal models, observations in humans, correlations in time, and pharmacological/toxicological considerations, it has been concluded without reasonable ...
William Parker +6 more
doaj +1 more source
Advanced Science, EarlyView.Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang +10 more
wiley +1 more source
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2015 BACKGROUND AND OBJECTIVE: Acetaminophen can induce liver damage via oxidative stress. This study aimed to evaluate the protective effects of fenugreek seed powder on oxidant and antioxidant factors in acetaminophen-induced liver toxicity.
A Mohammadzadeh, A Gol, H Oloumi
doaj
Attenuation of copaiba oil in hepatic damage in rats [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE: To investigate the copaiba oil on the hepatic damage induced by acetaminophen, comparing against corn oil. METHODS: Fifty four rats were distributed into nine study groups (N=6): control group, that didn't receive the acetaminophen ...
Marcus Vinicius Henriques Brito +6 more
doaj +1 more source
Acetaminophen hepatotoxicity: an updated review [PDF]
, 2015 As the most common cause of acute liver failure (ALF) in the USA and UK, acetaminophen-induced hepatotoxicity remains a significant public health concern and common indication for emergent liver transplantation.
Lancaster, Elizabeth M +2 more
core +1 more source
Advanced Science, EarlyView.An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng +17 more
wiley +1 more source
Acetaminophen for analgesia following pyloromyotomy: does the route of administration make a difference? [PDF]
, 2016 Arvid Yung,1 Arlyne Thung,1,2 Joseph D Tobias,1–3 1Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, 2Department of Anesthesiology and Pain Medicine, 3Department of Pediatrics, The Ohio State University ...
Tobias JD, Yung A, Thung AK
core
Advanced Science, EarlyView.A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen +15 more
wiley +1 more source
Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones
EBioMedicine, 2018 Background: Acetaminophen (paracetamol) is one of the most common medications used for management of pain in the world. There is lack of consensus about the mechanism of action, and concern about the possibility of adverse effects on reproductive health.
Isaac V. Cohen +9 more
doaj +1 more source
Advanced Science, EarlyView.In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin +8 more
wiley +1 more source