Results 51 to 60 of about 82,013 (311)

The Dangers of Acetaminophen for Neurodevelopment Outweigh Scant Evidence for Long-Term Benefits

Children, 2023
Based on available data that include approximately 20 lines of evidence from studies in laboratory animal models, observations in humans, correlations in time, and pharmacological/toxicological considerations, it has been concluded without reasonable ...
William Parker, Lauren G. Anderson, John P. Jones, Rachel Anderson, Lauren Williamson, Dillan Bono-Lunn, Zacharoula Konsoula   +6 more
doaj   +1 more source

An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Haemophilus influenzae type b vaccine

, 2013
BACKGROUND: In two clinical trials, low-grade fever was observed more frequently after coadministration than after separate administration of two recommended routine pediatric vaccines.
Rose, Markus A., William C Gruber, Sherryl Baker, Christine Juergens, Beate Schmoele-Thoma, Gruber, William C., Stefan Zielen, Zielen, Stefan, Jürgens, Christine, Schmoele-Thoma, Beate, Baker, Sherryl, Markus A Rose   +11 more
core   +1 more source

Acetaminophen hepatotoxicity: an updated review [PDF]

, 2015
As the most common cause of acute liver failure (ALF) in the USA and UK, acetaminophen-induced hepatotoxicity remains a significant public health concern and common indication for emergent liver transplantation.
Lancaster, Elizabeth M, Hiatt, Jonathan R, Zarrinpar, Ali   +2 more
core   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Attenuation of copaiba oil in hepatic damage in rats [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To investigate the copaiba oil on the hepatic damage induced by acetaminophen, comparing against corn oil. METHODS: Fifty four rats were distributed into nine study groups (N=6): control group, that didn't receive the acetaminophen ...
Marcus Vinicius Henriques Brito, Felipe D'Almeida Costa, Diego Matos de Vasconcelos, Lauro Augusto Veloso Costa, Edson Yuzur Yasojima, Renan Kleber Costa Teixeira, Vitor Nagai Yamaki   +6 more
doaj   +1 more source

Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression

, 2017
Background: Acetaminophen (APAP) overdose causes acute liver failure (ALF) in animals and humans via the rapid depletion of intracellular glutathione (GSH) and the generation of excess reactive oxygen species (ROS)that damage hepatocytes.
Huang, Yu-Jen;Chen, Poda;Lee, Chih-Yuan;Yang, Sin-Yu;Lin, Ming-Tsan;Lee, Hsuan-Shu;Wu, Yao-Ming, 林明燦;李志元;李宣書;吳耀銘   +1 more
core   +1 more source

Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive HARS1‐related disorder (originally described as Usher syndrome type 3B) caused by a homozygous Y454S variant in the histidyl‐tRNA synthetase gene (HARS1) is characterized by progressive sensorineural hearing and vision loss and respiratory deterioration with risk for sudden death following febrile illnesses.
Victoria Mok Siu, Rosan Kenana, Rana Chakrabarti, Sarah D. P. Wilhelm, Joseph Andrews, Susan J. Leat, Christina Parker, Michael Miller, Leslie A. Nangle, Wendy McCaul, Ashfia Chowdhury, Natalie Hutchings, Ryan A. Adams, Lauren Guy, Mandy Rhody, Verena Juncal, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Angelica A. Moresco, Daphne L. McCulloch, D. Holmes Morton, Ilka U. Heinemann, C. Anthony Rupar   +23 more
wiley   +1 more source

Effect of Piperine Pretreatment on Biochemical Profiles of Acetaminophen-Induced Hepatotoxicity in Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2012
BACKGROUND AND OBJECTIVE: Acetaminophen overdose is the most frequent cause of liver injuries. N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of acetaminophen induced by cytochrome P-450.
MT Kazemi, M Pour Nasrollah, MM Rezaei,, GH.A Jorsaraei, GH Maliji, S Kazemi, E Zabihi,, M Pouramir,, AA Moghadamnia   +8 more
doaj  

Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones

EBioMedicine, 2018
Background: Acetaminophen (paracetamol) is one of the most common medications used for management of pain in the world. There is lack of consensus about the mechanism of action, and concern about the possibility of adverse effects on reproductive health.
Isaac V. Cohen, Elizabeth T. Cirulli, Matthew W. Mitchell, Thomas J. Jonsson, James Yu, Naisha Shah, Tim D. Spector, Lining Guo, J. Craig Venter, Amalio Telenti   +9 more
doaj   +1 more source

Adiabatic calorimetry and thermal analysis on acetaminophen

, 2006
Molar heat capacities of acetaminophen were precisely measured with a small sample precision automated adiabatic calorimeter over the temperature range from 80 to 3 30 K. A solid-solid transition at 149.96 K was found from the C-p,C-.m-T curve.
Zhang, T, Sun, LX, Liang, JG, 孙立贤, Xu, F, Tan, ZC   +5 more
core   +1 more source