Results 61 to 70 of about 82,016 (264)

Effect of Piperine Pretreatment on Biochemical Profiles of Acetaminophen-Induced Hepatotoxicity in Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2012
BACKGROUND AND OBJECTIVE: Acetaminophen overdose is the most frequent cause of liver injuries. N-acetyl-p-benzoquinone imine (NAPQI) has been proposed as the toxic metabolite of acetaminophen induced by cytochrome P-450.
MT Kazemi, M Pour Nasrollah, MM Rezaei,, GH.A Jorsaraei, GH Maliji, S Kazemi, E Zabihi,, M Pouramir,, AA Moghadamnia   +8 more
doaj  

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

The effect of acetaminophen nanoparticles on liver toxicity in a rat model [PDF]

, 2010
Esmaeil Biazar1, S Mahdi Rezayat2, Naser Montazeri1, Khalil Pourshamsian1, Reza Zeinali3, Azadeh Asefnejad3, Mehdi Rahimi3, Mohammadmajid Zadehzare3, Mehran Mahmoudi3, Rohollah Mazinani3, Mehdi Ziaei31Department of Chemistry, Islamic Azad University ...
et al, Naser Montazeri, S Mahdi Rezayat, Esmaeil Biazar   +3 more
core  

Acetaminophen stimulates proliferation of breast cancer cells [PDF]

, 1999
Acetaminophen is a common analgesic/antipyretic. This research projected investigated the interaction of acetaminophen with breast cancer cells. The first goal was to determine if acetaminophen induces proliferation in cancerous and normal, human breast ...
Theophilus, Eugenia Harnagea
core   +2 more sources

Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive HARS1‐related disorder (originally described as Usher syndrome type 3B) caused by a homozygous Y454S variant in the histidyl‐tRNA synthetase gene (HARS1) is characterized by progressive sensorineural hearing and vision loss and respiratory deterioration with risk for sudden death following febrile illnesses.
Victoria Mok Siu, Rosan Kenana, Rana Chakrabarti, Sarah D. P. Wilhelm, Joseph Andrews, Susan J. Leat, Christina Parker, Michael Miller, Leslie A. Nangle, Wendy McCaul, Ashfia Chowdhury, Natalie Hutchings, Ryan A. Adams, Lauren Guy, Mandy Rhody, Verena Juncal, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Angelica A. Moresco, Daphne L. McCulloch, D. Holmes Morton, Ilka U. Heinemann, C. Anthony Rupar   +23 more
wiley   +1 more source

Evaluating the Role of Susceptibility Inducing Cofactors and of Acetaminophen in the Etiology of Autism Spectrum Disorder

Life
More than 20 previously reported lines of independent evidence from clinical observations, studies in laboratory animal models, pharmacokinetic considerations, and numerous temporal and spatial associations indicate that numerous genetic and ...
John P. Jones, Lauren Williamson, Zacharoula Konsoula, Rachel Anderson, Kathryn J. Reissner, William Parker   +5 more
doaj   +1 more source

Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose.

PLoS ONE, 2020
Acetaminophen is one of the most common over-the-counter pain medications used worldwide and is considered safe at therapeutic dose. However, intentional and unintentional overdose accounts for up to 70% of acute liver failure cases in the western world.
Sarah Piel, Imen Chamkha, Adam Kozak Dehlin, Johannes K Ehinger, Fredrik Sjövall, Eskil Elmér, Magnus J Hansson   +6 more
doaj   +1 more source

Evaluation of the Effects of TENS Therapy and Acetaminophen on Pain Alleviation in Initial Orthodontic Treatment [PDF]

Objective: This prospective study aimed to evaluate the analgesic effects of acetaminophen and Transcutaneous Electric Nerve Stimulation (TENS) therapy for pain control.
Kunal Sharma, Rajiv Ahluwalia, Stutee Grewal, Tina Chugh   +3 more
core   +1 more source

Effects of early life paracetamol use on the incidence of allergic disease and sensitization: 5 year follow-up of an Ethiopian birth cohort. [PDF]

, 2014
INTRODUCTION: The hypothesis that paracetamol, one of the most widely used medicines, may increase the risk of asthma and allergic disease is of obvious importance but prospective cohort data looking at dose and timing of exposure are lacking. OBJECTIVE:
Amberbir, Alemayehu, John Britton, Gail Davey (4462069), Andrea Venn, Medhin, Girmay, Girmay Medhin (347685), Britton, John, Alemayehu Amberbir (95491), Alemayehu Amberbir, Hanlon, Charlotte, Charlotte Hanlon, Andrea Venn (347686), John Britton (70864), Gail Davey (155158), Gail Davey, Charlotte Hanlon (291709), Venn, Andrea, Girmay Medhin, Davey, Gail   +18 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source