Results 61 to 70 of about 88,369 (298)

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Evaluating the Role of Susceptibility Inducing Cofactors and of Acetaminophen in the Etiology of Autism Spectrum Disorder

Life
More than 20 previously reported lines of independent evidence from clinical observations, studies in laboratory animal models, pharmacokinetic considerations, and numerous temporal and spatial associations indicate that numerous genetic and ...
John P. Jones, Lauren Williamson, Zacharoula Konsoula, Rachel Anderson, Kathryn J. Reissner, William Parker   +5 more
doaj   +1 more source

Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose.

PLoS ONE, 2020
Acetaminophen is one of the most common over-the-counter pain medications used worldwide and is considered safe at therapeutic dose. However, intentional and unintentional overdose accounts for up to 70% of acute liver failure cases in the western world.
Sarah Piel, Imen Chamkha, Adam Kozak Dehlin, Johannes K Ehinger, Fredrik Sjövall, Eskil Elmér, Magnus J Hansson   +6 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Therapeutic doses of acetaminophen with co-administration of cysteine and mannitol during early development result in long term behavioral changes in laboratory rats.

PLoS ONE, 2021
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders.
Navneet Suda, Jasmine Cendejas Hernandez, John Poulton, John P Jones, Zacharoula Konsoula, Caroline Smith, William Parker   +6 more
doaj   +1 more source

Acetaminophen (Paracetamol) [PDF]

Journal of Pain and Symptom Management, 2013
Therapeutic Reviews aim to provide essential independent information for health professionals about drugs used in palliative and hospice care. Additional content is available on www.palliativedrugs.com. Country-specific books (Hospice and Palliative Care Formulary USA, and Palliative Care Formulary, British and Canadian editions) are also available and
Robert, Twycross, Victor, Pace, Mary, Mihalyo, Andrew, Wilcock   +3 more
openaire   +2 more sources

Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose

, 1985
The effect of a toxic dose of acetaminophen on the hepatic conjugations of acetaminophen was studied in single pass perfused livers from rats given acetaminophen overdose 12 hr prior to perfusion and from control rats.
Skovgaard, Lene T., Lerche, Anette, Poulsen, Henrik E.   +2 more
core   +1 more source

Postnatal Acetaminophen and Potential Risk of Autism Spectrum Disorder among Males

Behavioral Sciences, 2020
Some evidence from the literature suggests that postnatal acetaminophen exposure may be associated with increased risk of autism spectrum disorder (ASD). Using a data set obtained from a previous study that was derived from an Internet-based survey among
Seth S. Bittker, Kathleen R. Bell
doaj   +1 more source

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source