Acetaminophen Hepatotoxicity [PDF]
Seminars in Liver Disease, 2019 AbstractAcetaminophen (APAP) is one of the most popular and safe pain medications worldwide. However, due to its wide availability, it is frequently implicated in intentional or unintentional overdoses where it can cause severe liver injury and even acute liver failure (ALF).
Anup, Ramachandran, Hartmut, Jaeschke
openaire +3 more sources
Prevalence, perceptions and factors associated with non-adherence to hepatotoxicity monitoring among people living with HIV on tuberculosis preventive treatment at Mulago ISS clinic. [PDF]
PLoS ONEIntroductionHepatotoxicity monitoring is recommended for people living with HIV (PLHIV) enrolled on tuberculosis preventive treatment (TPT). Despite a 7.3% hepatotoxicity incidence reported in a multi-country study, implementation and adherence to ...
Kevin Naturinda +10 more
doaj +2 more sources
Real-world evidence of ribociclib-induced hepatotoxicity in patients with breast cancer: a multi-center experience [PDF]
BMC CancerBackground CDK4/6 inhibitors are primarily used to treat hormone-positive HER-2 negative (HR+/ HER2-) metastatic breast cancer. Although ribociclib is generally well-tolerated, there is limited real-world data on hepatotoxicity associated with its use ...
Onur Baş +11 more
doaj +2 more sources
High dose atorvastatin associated with increased risk of significant hepatotoxicity in comparison to simvastatin in UK GPRD cohort [PDF]
, 2016 Background and Aims: Occasional risk of serious liver dysfunction and autoimmune hepatitis during atorvastatin therapy has been reported. We compared the risk of hepatotoxicity in atorvastatin relative to simvastatin treatment.
Clarke, Alan T. +4 more
core +17 more sources
Association of Cytochrome P450 2E1 and N-Acetyltransferase 2 Genotypes with Serum Isoniazid Level and Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Cross-Sectional Study [PDF]
Iranian Journal of Medical Sciences, 2023 Background: Anti-tuberculosis drug-induced hepatotoxicity can result from genetic polymorphism of the isoniazid (INH) metabolizing enzyme. This study aimed to determine the effect of genetic polymorphism of N-acetyltransferase 2 (NAT2) and cytochrome ...
Nasir Pourmohamadi +4 more
doaj +1 more source
Journal of Hepatology, 2022 BACKGROUND & AIMS Acetaminophen (APAP) is the most common cause of drug-induced liver injury (DILI); however, treatment options are limited. Mas is a G protein-coupled receptor whose role in APAP-induced hepatotoxicity has not yet been examined ...
Shuai Chen +11 more
semanticscholar +1 more source
The role of natural antioxidants in cisplatin-induced hepatotoxicity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021 Cisplatin is a potent platinum-based anticancer drug approved by the Food Drug Administration (FDA) in 1978. Despite its advantages against solid tumors, cisplatin confers toxicity to various tissues that limit its clinical uses.
Norhashima Abd Rashid +6 more
semanticscholar +1 more source
Machine Learning Approaches to Predict Hepatotoxicity Risk in Patients Receiving Nilotinib
Molecules, 2021 Background: Although nilotinib hepatotoxicity can cause severe clinical conditions and may alter treatment plans, risk factors affecting nilotinib-induced hepatotoxicity have not been investigated.
Jung-Sun Kim +4 more
doaj +1 more source
Coumarin-Induced Hepatotoxicity: A Narrative Review
Molecules, 2022 Coumarin is an effective treatment for primary lymphoedema, as well as lymphoedema related to breast cancer radiotherapy or surgery. However, its clinical use is limited in several countries due to the possible occurrence of hepatotoxicity, mainly in the
Michele Pitaro +5 more
semanticscholar +1 more source
The molecular pathogenesis of triptolide-induced hepatotoxicity
Frontiers in Pharmacology, 2022 Triptolide (TP) is the major pharmacologically active ingredient and toxic component of Tripterygium wilfordii Hook. f. However, its clinical potential is limited by a narrow therapeutic window and multiple organ toxicity, especially hepatotoxicity ...
Yeqing Hu +19 more
doaj +1 more source