Results 41 to 50 of about 103,692 (253)

Treatment with gefitinib after erlotinib-induced liver injury: a case report

Journal of Medical Case Reports, 2011
Introduction Gefitinib and erlotinib have minor differences in their chemical structures, and thus it remains unclear whether the hepatotoxicity induced by one compound is affected by the other. The case of a patient who developed erlotinib-induced liver
Nakatomi Katsumi, Nakamura Yoichi, Tetsuya Iida, Kohno Shigeru   +3 more
doaj   +1 more source

Chemical and biochemical aspects of drug-induced liver injury [PDF]

, 2011
Adverse drug reactions (ADRs) are a major obstacle for the development of new medicines. They are also a leading cause of patient morbidity and mortality. Although ADRs affect many different organs and bodily systems, drug induced liver injury has lead to the withdrawal of several drugs at the post licensing stage, and is a key cause of drug attrition.
openaire   +1 more source

Additional file 7 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 7: TableS2. Proteins with high feature importance in RF and SVM, and links to DILI. The 19 proteins with the highest feature importance in RF or SVM models are shown. The feature importance is shown in bold if the protein ranked among the top 19 in the respective model.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
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Does drug-induced liver injury still occur after sevoflurane anesthesia? -A case report- [PDF]

Anesthesia and Pain Medicine
Background Several factors contribute to post-anesthetic hepatic dysfunction, including a decrease in oxygen supply to the liver, direct physical compression of the liver, viral hepatitis, blood transfusions, preexisting hepatic dysfunction, and the use ...
Moon Ok Lee, Seonghyeon Cho, Chaeeun Kim, Hanna Koh   +3 more
doaj   +1 more source

Additional file 8 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 8: TableS3. Pathways with high feature importance in RF and SVM, and links to DILI. The overrepresented gene sets for 19 proteins with the highest feature importance in RF or SVM models are shown. Many pathways identified possess known functions in liver drug metabolism and cell stress.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
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Additional file 4 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 4: Figure S3. Enriched pathways across different feature importance cutoffs for RF using the DILIrank (−vLessConcern) dataset. Enriched pathways are shown across different feature importance cutoffs which are identified by the percentile of DILI-enriched protein targets covered.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
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Drug and herb-induced liver injury: A critical review of Brazilian cases with proposals for the improvement of causality assessment using RUCAM

Annals of Hepatology, 2019
Introduction and Objectives: Although hepatotoxicity accounts for 10% of adverse drug reactions, it remains poorly understood and underreported. This study aimed to summarize case reports of herb- and drug-induced liver injury in Brazil.
Matheus William Becker, Michele John Muller Lunardelli, Cristiane Valle Tovo, Carine Raquel Blatt   +3 more
doaj   +1 more source

Additional file 6 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 6: Table S1. Performance of models trained using the DILIrank (−vLessConcern) dataset. Shown is mean ± standard deviation for 7 metrics (MCC - Matthew’s Correlation Coefficient, PRAUC - Precision-Recall Area Under Curve, ROCAUC - Receiver-Operator-Characteristic Area Under Curve) for models trained using ECFP4, Mordred molecular ...
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
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Pantoprazole-Induced Liver Injury in the Setting of Diabetic Ketoacidosis

Acta Médica Portuguesa
N/a.
Raquel Oliveira, Manuel Almeida, Pedro Lavado, Alexandre Baptista   +3 more
doaj   +1 more source

Additional file 1 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 1: SI. Overview of gene expression data preparation, DILI model generation, and DILI label prediction performance for models derived using L1000 gene expression data. Gene expression data for 14 distinct cell line-time-dose combinations was extracted for all compounds with DILI labels.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources