Results 21 to 30 of about 103,692 (253)

Supervised chemical graph mining improves drug-induced liver injury prediction

iScience, 2023
Drug-induced liver injury (DILI) is the main cause of drug failure in clinical trials. The characterization of toxic compounds in terms of chemical structure is important because compounds can be metabolized to toxic substances in the liver. Traditional machine learning approaches have had limited success in predicting DILI, and emerging deep graph ...
Sangsoo Lim, Youngkuk Kim, Jeonghyeon Gu, Sunho Lee, Wonseok Shin, Sun Kim   +5 more
openaire   +3 more sources

LIVER INJURY INDUCED BY HERBAL AND DIETARY SUPPLEMENTS: A POOLED ANALYSIS OF CASE REPORTS

Arquivos de Gastroenterologia, 2022
Background: The intake of dietary supplements and medicinal plants is very popular worldwide. However, these products are not innocuous, and their intake can cause severe damage to health, especially liver injury. Objective: This study aims to describe
Michelle Hoff de ASSIS, Bruna Cherubini ALVES, Vivian Cristine LUFT, Valesca DALL’ALBA   +3 more
doaj   +1 more source

Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction [PDF]

Biology Direct, 2020
Abstract Motivation Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials.
Wojciech Lesiński, Krzysztof Mnich, Agnieszka Kitlas Golińska, Witold R. Rudnicki   +3 more
openaire   +3 more sources

Drug-induced liver injury due to tofacitinib: a case report

Journal of Medical Case Reports, 2023
Background Drug-induced liver injury is an acute or chronic liver damage in response to drugs, herbals, and any chemical compound. Case presentation In the present work, liver failure following the use of tofacitinib was reported.
Masoud Mardani, Jafar Mohammadshahi, Sara abolghasemi, Roghayeh Teimourpour   +3 more
doaj   +1 more source

The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and metabonomics

Food Science and Human Wellness, 2021
Trametes lactinea mycelia polysaccharides (TLMPS) have a wide range of bioactivities. The potential mechanisms of action of TLMPS against acute alcohol-induced liver injury in vivo were investigated by analyzing the physical and chemical properties of ...
Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu   +5 more
doaj   +1 more source

Drug induced liver injury: East versus West – a systematic review and meta-analysis [PDF]

Clinical and Molecular Hepatology, 2020
Drug induced liver injury (DILI) may be different in the East compared to the West due to differing disease prevalence, prescribing patterns and pharmacogenetic profiles.
En Xian Sarah Low, Qishi Zheng, Edwin Chan, Seng Gee Lim   +3 more
doaj   +1 more source

dialogi: Utilising NLP With Chemical and Disease Similarities to Drive the Identification of Drug-Induced Liver Injury Literature

Frontiers in Genetics, 2022
Drug-Induced Liver Injury (DILI), despite its low occurrence rate, can cause severe side effects or even lead to death. Thus, it is one of the leading causes for terminating the development of new, and restricting the use of already-circulating, drugs.
Nicholas M. Katritsis, Nicholas M. Katritsis, Anika Liu, Anika Liu, Gehad Youssef, Sanjay Rathee, Méabh MacMahon, Méabh MacMahon, Woochang Hwang, Lilly Wollman, Namshik Han, Namshik Han   +11 more
openaire   +3 more sources

Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury [PDF]

Toxicological Sciences, 2020
Abstract Drug-induced liver injury is a major reason for drug candidate attrition from development, denied commercialization, market withdrawal, and restricted prescribing of pharmaceuticals. The metabolic bioactivation of drugs to chemically reactive metabolites (CRMs) contribute to liver-associated adverse drug reactions in humans that
Monroe, James J, Tanis, Keith Q, Podtelezhnikov, Alexei A, Nguyen, Truyen, Machotka, Sam V, Lynch, Donna, Evers, Raymond, Palamanda, Jairam, Miller, Randy R, Pippert, Todd, Cabalu, Tamara D, Johnson, Timothy E, Aslamkhan, Amy G, Kang, Wen, Tamburino, Alex M, Mitra, Kaushik, Agrawal, Nancy G B, Sistare, Frank D   +17 more
openaire   +2 more sources

Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs

PLOS ONE, 2021
Drug-induced liver injury (DILI) is one of major causes of discontinuing drug development and withdrawing drugs from the market. In this study, we investigated chemical properties associated with DILI using in silico methods, to identify a physicochemical property useful for DILI screening at the early stages of drug development.
Yuki Shimizu, Takamitsu Sasaki, Jun-ichi Takeshita, Michiko Watanabe, Ryota Shizu, Takuomi Hosaka, Kouichi Yoshinari   +6 more
openaire   +4 more sources

Hyperin protects against cisplatin-induced liver injury in mice [PDF]

Acta Cirúrgica Brasileira, 2017
Purpose: To evaluate the effect of hyperin in cisplatin-induced liver injury in mice. Methods: Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six days, and intraperitoneal injection of cisplatin (40 mg/kg) was ...
Chengwei Niu, Man Ma, Xiao Han, Zimin Wang, Hangyan Li   +4 more
doaj   +1 more source