Results 21 to 30 of about 197,386 (292)

Cardiovascular and hepatic toxicity of cocaine: potential beneficial effects of modulators of oxidative stress [PDF]

, 2015
Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with ...
Antonilli, Letizia, Badiani, Aldo, Grassi, Maria Caterina, Graziani, Manuela, Saso, Luciano, Togna, Anna Rita   +5 more
core   +12 more sources

LIVER INJURY INDUCED BY HERBAL AND DIETARY SUPPLEMENTS: A POOLED ANALYSIS OF CASE REPORTS

Arquivos de Gastroenterologia, 2022
Background: The intake of dietary supplements and medicinal plants is very popular worldwide. However, these products are not innocuous, and their intake can cause severe damage to health, especially liver injury. Objective: This study aims to describe
Michelle Hoff de ASSIS, Bruna Cherubini ALVES, Vivian Cristine LUFT, Valesca DALL’ALBA   +3 more
doaj   +1 more source

Supervised chemical graph mining improves drug-induced liver injury prediction

iScience, 2023
Drug-induced liver injury (DILI) is the main cause of drug failure in clinical trials. The characterization of toxic compounds in terms of chemical structure is important because compounds can be metabolized to toxic substances in the liver. Traditional machine learning approaches have had limited success in predicting DILI, and emerging deep graph ...
Sangsoo Lim, Youngkuk Kim, Jeonghyeon Gu, Sunho Lee, Wonseok Shin, Sun Kim   +5 more
openaire   +3 more sources

Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction [PDF]

Biology Direct, 2020
Abstract Motivation Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials.
Wojciech Lesiński, Krzysztof Mnich, Agnieszka Kitlas Golińska, Witold R. Rudnicki   +3 more
openaire   +3 more sources

Development on Animal Models for Drug/Chemical Induced Liver Injury

Biomedical and Pharmacology Journal, 2023
In the human body, the largest gland is the liver and does a lot of essential work of the body. Liver damage is the cause of mortality and increasing day by day. Liver disease is caused by multiple factors, such as an autoimmune condition, toxic chemical exposure, viral infection, and dietary factors.
Deepika Bhatia, Yogeeta Yogeeta, Pradeep Goyal, Atul Kabra   +3 more
openaire   +1 more source

Drug-induced liver injury due to tofacitinib: a case report

Journal of Medical Case Reports, 2023
Background Drug-induced liver injury is an acute or chronic liver damage in response to drugs, herbals, and any chemical compound. Case presentation In the present work, liver failure following the use of tofacitinib was reported.
Masoud Mardani, Jafar Mohammadshahi, Sara abolghasemi, Roghayeh Teimourpour   +3 more
doaj   +1 more source

The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and metabonomics

Food Science and Human Wellness, 2021
Trametes lactinea mycelia polysaccharides (TLMPS) have a wide range of bioactivities. The potential mechanisms of action of TLMPS against acute alcohol-induced liver injury in vivo were investigated by analyzing the physical and chemical properties of ...
Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu   +5 more
doaj   +1 more source

Drug induced liver injury: East versus West – a systematic review and meta-analysis [PDF]

Clinical and Molecular Hepatology, 2020
Drug induced liver injury (DILI) may be different in the East compared to the West due to differing disease prevalence, prescribing patterns and pharmacogenetic profiles.
En Xian Sarah Low, Qishi Zheng, Edwin Chan, Seng Gee Lim   +3 more
doaj   +1 more source

INFLUENCE OF HIGH-DOSE ATORVASTATIN ON BILE ACID METABOLISM IN MICE WITH LIVER INJURY AND RELATED MECHANISM [PDF]

精准医学杂志, 2023
Objective To investigate the influence of high-dose atorvastatin on bile acid metabolism in mice with liver injury and its mechanism. Methods A total of 40 specific pathogen-free male C57BL/6 mice were randomly divided into normal saline group (group A ...
XIA Feifei, SONG Bingxue, SONG Yuqing, TIAN Jiawei, YAN Hui, HUANG Yuxiao, XIN Hui, LIANG Hui
doaj   +1 more source

dialogi: Utilising NLP With Chemical and Disease Similarities to Drive the Identification of Drug-Induced Liver Injury Literature

Frontiers in Genetics, 2022
Drug-Induced Liver Injury (DILI), despite its low occurrence rate, can cause severe side effects or even lead to death. Thus, it is one of the leading causes for terminating the development of new, and restricting the use of already-circulating, drugs.
Nicholas M. Katritsis, Nicholas M. Katritsis, Anika Liu, Anika Liu, Gehad Youssef, Sanjay Rathee, Méabh MacMahon, Méabh MacMahon, Woochang Hwang, Lilly Wollman, Namshik Han, Namshik Han   +11 more
openaire   +3 more sources