Results 21 to 30 of about 58,096 (266)

In vitro demonstration of herbal exacerbation of paracetamol-induced hepatotoxicity

Phytomedicine Plus, 2022
Background: Paracetamol (acetaminophen) is one of the most accessible pharmaceutical analgesic and antipyretic agents. Similarly, traditional herbal medicines including Psoralea corylifolia, Astragalus propinquus and Atractylodes macrocephala have been ...
Susan M. Britza, Rachael Farrington, Roger W. Byard, Ian F. Musgrave   +3 more
doaj   +1 more source

Egyptian perspectives on potential risk of paracetamol/acetaminophen-induced toxicities: Lessons learnt during COVID-19 pandemic

Toxicology Reports, 2022
Paracetamol/Acetaminophen was widely used as a first-line antipyretic and analgesic for COVID-19 patients without giving any attention to the potential risk of related toxicities.
Enas M.A. Mostafa, Ayat M. Tawfik, Khadiga M. Abd-Elrahman   +2 more
doaj   +1 more source

Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses

Acta Medica Alanya, 2020
Aim: Paracetamol is widely used by important societal groups such as pregnant women and the elderly. Paracetamol, taken in high doses especially during pregnancy, causes liver failure.
Seher Yi̇lmaz, Yeşim Göçmen, Adem Tokpınar, İlyas Uçar, Şükrü Ateş, Seda Avni̇oğlu, Mehtap Ni̇sari̇   +6 more
doaj   +1 more source

Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamol

iScience, 2023
Summary: Prenatal paracetamol exposure has been associated with neurodevelopmental outcomes in childhood. Pharmacoepigenetic studies show differences in cord blood DNA methylation between unexposed and paracetamol-exposed neonates, however, causality and
Mari Spildrejorde, Athina Samara, Ankush Sharma, Magnus Leithaug, Martin Falck, Stefania Modafferi, Arvind Y.M. Sundaram, Ganesh Acharya, Hedvig Nordeng, Ragnhild Eskeland, Kristina Gervin, Robert Lyle   +11 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

A New Sensor Based on Graphite Screen Printed Electrode Modified With Cu-Nanocomplex for Determination of Paracetamol [PDF]

Nanochemistry Research, 2017
Paracetamol is a non-steroidal anti-inflammatory drug used as an antipyretic agent for the alternative to aspirin. Conversely, the overdoses of paracetamol can cause hepatic toxicity and kidney damage.
Hadi Beitollai, Reza Zaimbashi
doaj   +1 more source

Isolation of Novel Bacterial Strains Pseudomonas extremaustralis CSW01 and Stutzerimonas stutzeri CSW02 from Sewage Sludge for Paracetamol Biodegradation

Microorganisms, 2023
Paracetamol is one of the most used pharmaceuticals worldwide, but due to its widespread use it is detected in various environmental matrices, such as surface and ground waters, sediments, soils or even plants, where it is introduced mainly from the ...
Antonio Vargas-Ordóñez, Inés Aguilar-Romero, Jaime Villaverde, Fernando Madrid, Esmeralda Morillo   +4 more
doaj   +1 more source

HEPATOPROTECTIVE AND ANTIOXIDANT EFFECT OF FLAVONOID, GOLD AND SILVER NANOPARTICLES AGAINST PARACETAMOL INDUCED LIVER TOXIC IN MALE RATS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Research Design at university of Karbala , 60 adult male rats, aged 9 to 12 weeks and weighing between 190 and 315 grams, were used, divisions to 10 group (G1 The control just received 0.85% saline solution , G2 : 1000 mg of paracetamol and 0.2 mg of Ag ...
Roaa Al-Samak, Ebtihal jawad sajit, Muna Mohammed Gani Al-Shimmery, Bashaaar Ali   +3 more
doaj   +1 more source

Comparative evaluation of biochemical effects of date palm (Phoenix dactylifera) fruit extracts on paracetamol-induced hepatotoxicity in Wistar rats

Journal of Applied Sciences and Environmental Management, 2019
The therapeutic activity of date palm extracts (Phoenix dactylifera) against paracetamol-induced hepatotoxicity was studied in rats of the Wistar strain. Forty-eight (48) Wistar rats were assigned into 8 groups equally.
O Ikponmwosa-Eweka, A.I. Eromosele
doaj   +1 more source

Protective role of Chlorella vulgaris with Thiamine against Paracetamol induced toxic effects on haematological, biochemical, oxidative stress parameters and histopathological changes in Wistar rats

Scientific Reports, 2021
Paracetamol is extensively consumed as an analgesic and antipyretic drug, but at a high dose level, it leads to deleterious side effects, such as hepatic and nephrotoxicity.
Amera Abd El Latif, Doaa H. Assar, Ebtihal M. Elkaw, Hanafy A. Hamza, Dalal Hussien M. Alkhalifah, Wael N. Hozzein, Ragaa A. Hamouda   +6 more
doaj   +1 more source