Results 51 to 60 of about 1,308 (200)

Riluzole‐Derived Benzo[d]thiazoles as CK1δ Inhibitors for Amyotrophic Lateral Sclerosis‐Related Neurodegeneration

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Riluzole metabolism guided the design of benzo[d]thiazole inhibitors of casein kinase 1 delta (CK1δ), a kinase linked to amyotrophic lateral sclerosis (ALS). Docking supported ATP site recognition by the hydroxylamine metabolite and hydrazine analogues, leading to compounds showing improved potency and retained predicted blood brain barrier ...
Simone Adorinni, Ilenia Grieco, Stefano Morasso, Michelle Fornasier, Gianluca Novello, Veronica Salmaso, Loreto Martínez‐González, Eleonora Cescon, Davide Bassani, Giovanni Adriano Bassan, Teresa Gianferrara, Filippo Prencipe, Veronika Kost, Tatiana Da Ros, Paola Storici, Ana Martinez, Giampiero Spalluto, Stefano Moro, Stephanie Federico   +18 more
wiley   +1 more source

Synthesis of novel pyrano[2,3-b]quinolines from simple acetanilides via intramolecular 1,3-dipolar cycloaddition [PDF]

, 2006
Some novel isoxazole and pyrazole fused pyrano[2,3-b]quinolines were synthesized from simple acetanilides via intramolecular 1,3-dipolar cycloaddition reactions involving nitrones, nitrile oxides and nitrile imines as 1,3-dipoles, in a regioselective ...
BARUAH , B, BHUYAN , P J, KALITA , P K
core  

Substituent Effects on Homolytic Bond Dissociation Free Energies of Oxygen--Acetyl Bonds in Phenyl Acetates and Nitrogen--Acetyl Bonds in Acetanilides.

, 1996
The use of thermochemical cycles makes it possible to determine substituent effects on the homolytic bond dissociation free energies, BDFE, of the oxygen-acetyl bonds in substituted phenyl acetates and the nitrogen-acetyl bonds in substituted ...
Andersen, Mogens L., Neucírio Ricardo de Azevedo, Mogens L. Andersen, Kjell Undheim, Kristian Rønning Pedersen, Muhammed Nour Homsi, Pedro Henrique Ferri, Elmar G. Weinhold, Tore Benneche, Nathalie Trabesinger-Rüf, Monika Haugg, Frank K. H. Kuske   +11 more
core   +1 more source

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

Buccal absorption as a parameter of analgesic activity of some p-substituted acetanilides

, 1971
The extent of buccal absorption of 16 p-substituted acetanilides is related parabolically to analgesic activity. The correlation is slightly better than that between log (partition coefficient) and analgesic activity.
J C DEARDEN, ERIC TOMLINSON
core   +1 more source

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

Potential Local Anaesthetics. Part- IX. Syntheis of Diethylamino- Morpholino-Piperidino-N -(Substituted Benzyl)-Acetanilides:

, 1973
Chemical Laboratory, Smt. B. C. J. Science College, Cambay Manuscript received 10 October 1971; revised 17 July 1972; accepted 6 February 1973 Benzyl anilines were condensed with chloroacetyl chloride and the resulting chloroacetanilides on heating ...
J. J. TRIVEDI, P. B. PATEL
core   +1 more source

The Dangers of Acetanilid. [PDF]

JAMA: The Journal of the American Medical Association, 1905
Dodge City, Kan., July 14, 1905. To the Editor: -I was walking along the street some months ago and overtook my venerable friend, the Methodist minister, who said "Doctor, I'm glad to see you. What is antikamnia?" I told him that it is a mixture of uncertain composition, used with greater or less success for the relief of pain; that its principal ...
openaire   +2 more sources

Structure–Activity Relationships of 1,4‐Benzodiazepines Inhibiting the Voltage‐Gated Potassium Channel KV7.1

Archiv der Pharmazie, Volume 359, Issue 10, October 2026.
KV7.1 antagonists hold potential for the treatment of diarrhea, reflux esophagitis, and hypoinsulinemia. To derive structure–activity relationships, the lead KV7.1 antagonist L768,673 was thoroughly modified in 1‐ and 3‐positions. The 3‐fluoropropyl‐substituted 1,4‐benzodiazepine showed promising KV7.1 inhibitory activity, qualifying it as a potential ...
Florian Roßner, Amy Methaq, Guiscard Seebohm, Bernhard Wünsch   +3 more
wiley   +1 more source

Subsurface Hydrocarbon Biodegradation in the Context of Microbial Habitability and Hydrogeologic, Thermal, and Geologic Evolution of the Colorado Plateau

Journal of Geophysical Research: Biogeosciences, Volume 131, Issue 10, October 2026.
Abstract Subsurface microbial ecosystems associated with hydrocarbon reservoirs are shaped by temperature, salinity, redox gradients, and fluid flow. However, the drivers of microbial activity and hydrocarbon biodegradation over geologic timescales remain poorly constrained.
Meera P. Shah, Jennifer McIntosh, Peter Reiners, Lydia Bailey, Bradley S. Stevenson, Grant Ferguson, Ji‐Hyun Kim, Henrik Drake, Magdalena R. Osburn   +8 more
wiley   +1 more source