Results 11 to 20 of about 11,662 (146)

Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]

, 2007
We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Ida J. van der Klei, Loknath Gidijala, Kiel, Jan A. K. W., Gidijala, Loknath, Klei, Ida J. van der,, van der Klei, Ida J., Jan A.K.W. Kiel, Veenhuis, Marten,, Gidijala, Loknath,, Kiel, Jan A.K.W.,, Marten Veenhuis, Veenhuis, Marten, van der Klei, Ida J.; id_orcid   +12 more
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Biosynthesis of lignans. Part I . Biosynthesis of Arctiin (3) and Phillyrin (5) [PDF]

, 1977
Lignans constitute a class of naturally occuring phenolic compounds, widely distributed in higher plants. They are formally composed of two phenylpropanoid units, stercospecifically joined at the /f-carbon atoms of their side chains. Their biosynthesis
Klischies, Martina, Stöckigt, Joachim
core   +1 more source

Bioinformatic Analysis ofLeishmania donovaniLong-Chain Fatty Acid-CoA Ligase as a Novel Drug Target [PDF]

, 2011
Fatty acyl-CoA synthetase (fatty acid: CoA ligase, AMP-forming; (EC 6.2.1.3)) catalyzes the formation of fatty acyl-CoA by a two-step process that proceeds through the hydrolysis of pyrophosphate.
Neeloo Singh, Jaspreet Kaur, Arun Kumar, Rameshwar Tiwari   +3 more
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Characterization of a phenylacetate–CoA ligase from Penicillium chrysogenum [PDF]

, 2008
Enzymatic activation of PAA (phenylacetic acid) to phenylacetyl-CoA is an important step in the biosynthesis of the β-lactam antibiotic penicillin G by the fungus Penicillium chrysogenum.
van den Berg, Marco A., Jekel, Peter A., Koetsier, Martijn J., Janssen, Dick B., Bovenberg, Roel A. L., Koetsier, Martijn J.,, Jekel, Peter A.,, Berg, Marco A. van den,, Bovenberg, Roel A.L.,, Janssen, Dick B.,   +9 more
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Two transgenic mouse models for beta subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations [PDF]

, 2016
Succinate-CoA ligase is a heterodimer enzyme composed of Suclg1 -alpha- and a substrate-specific Sucla2 or Suclg2 -beta- subunit yielding ATP or GTP, respectively.
Ravasz, Dóra, Adam-Vizi, Vera, Patócs, Attila Balázs, Molnár, Mária Judit, Madgar, Ory, Gál, Anikó, Araki, Masatake, Madgar O,, Ilin, Polina, Miller, Chaya, Saada, Ann, Nakahara, Mai, Vargedo, Zsuzsanna, Németh, Beáta, Ito, Haruka, Kacsó, Gergely, Iordanov, Iordan, Ádám, Veronika, Madgar, O., Araki, Kimi, Patocs, Attila, Chinopoulos, Christos, Vizi-Ádám, Vera, Adams, Daniel, Nagy, Zsolt, Dóczi, Judit, Molnár, Mária J, Ostergaard, Elsebet   +27 more
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Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Biotransormations with plant coenzyme A-dependent acyltransferases [PDF]

, 2008
The acylation of plant natural products is widely observed in nature and this modification often confers novel bioactivities. In nature, each of these acylations is selectively catalysed by a coenzyme A-dependent acyltransferase and biotransformations ...
Cunningham, Oliver David
core  

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme

, 2018
Acyl-coenzyme A (CoA) ligases catalyze the activation of carboxylic acids via a two-step reaction of adenylation followed by thioesterification. Here, we report the discovery of a non-adenylating acyl-CoA ligase PtmA2 and the functional separation of an ...
Liao-Bin Dong, Wang, Nan L., Dong, Liao-Bin, Babnigg, Gyorgy, Chang, Chin-Yuan, Osipiuk, Jerzy, Endres, Michael, Rudolf, Jeffrey D., Shen, Ben, George N. Phillips, Hatzos-Skintges, Catherine, Catherine Hatzos-Skintges, Joachimiak, Andrzej, Phillips, George N.Jr., Nan Wang, Ben Shen, Jeffrey D. Rudolf, Chin-Yuan Chang, Gyorgy Babnigg, Michael Endres, Jerzy Osipiuk, Andrzej Joachimiak   +21 more
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Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source