Results 31 to 40 of about 11,662 (146)

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Unidirectional transport of the mitochondrial GTP/GDP carrier in Saccharomyces cerevisiae

, 2015
Ggc1p is a yeast mitochondrial carrier protein involved in the GTP/GDP transport. This protein encoded by YDL198c gene has been shown to be a multicopy suppressor (by an unknown mechanism) of the ability of the abf2 null mutant to grow at 37°C on ...
Ventrella, Angela, Li, Yuan, VOZZA, Angelo, VILLALOBOS COA, VALENTINA LOIRA, MAROBBIO, CARLO MARYA   +4 more
core   +1 more source

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, Volume 38, Issue 31, 2 June 2026.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering [PDF]

International audienceThe CoA ligase from Metallosphaera sedula ( Ms ACL) can be used for the chemoenzymatic synthesis of amides from carboxylic acids. In this CoA-independent conversion, the enzyme catalyzes the adenylation of a carboxylic acid with the
Andy-Mark W. H. Thunnissen, Capra, Nikolas, Chloé Lelièvre, Capra, Nikolas; id_orcid, Zaparucha, Anne, Dick B. Janssen, Vergne-Vaxelaire, Carine, Aurélie Fossey-Jouenne, Fossey-Jouenne, Aurélie, Janssen, Dick, Nikolas Capra, Carine Vergne-Vaxelaire, Lelièvre, Chloé, Thunnissen, Andy-Mark W. H.; id_orcid, Touré, Océane, Océane Touré, Thunnissen, Andy-Mark, Anne Zaparucha   +17 more
core   +1 more source

Inactivation of Escherichia coli 2-amino-3-ketobutyrate CoA ligase by phenylglyoxal and identification of an active-site arginine peptide [PDF]

, 1992
Treatment of homogeneous preparations of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli, a pyridoxal 5'-phosphate-dependent enzyme, with phenylglyoxal, 4-(oxyacetyl)phenoxyacetic acid, 2,3-butanedione, or 1,2-cyclohexanedione results in a time ...
Dekker, Eugene E., Mukherjee, Jagat J.
core   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, Volume 13, Issue 31, 4 June 2026.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Kinetically and Crystallographically Guided Mutations of a Benzoate CoA Ligase (BadA) Elucidate Mechanism and Expand Substrate Permissivity

, 2015
A benzoate CoA ligase (BadA), isolated from the bacterium Rhodopseudomonas palustris, catalyzes the conversion of benzoate to benzoyl CoA on the catabolic pathway of aromatic carboxylic acids.
Kevin D. Walker (1441066), Chelsea K. Thornburg (1512334), James H. Geiger (1366794), Susan Wortas-Strom (1512331), Meisam Nosrati (1371714)   +4 more
core   +1 more source

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang, Yifeng Wei, Xumei Liu, Dazhi Liu, Zhenyu Liu, Yang Tong, Jinyu Yin, Ankanahalli N. Nanjaraj Urs, Meining Xing, Mark A. Harrison, Chuyuan Zhang, Sheng Yang, Yunzi Luo, Ee Lui Ang, Huimin Zhao, Yan Zhang   +15 more
wiley   +1 more source

All You Can Eat Yeast: Substituting Hexose Transporters With AtSWEET7 Alleviates Glucose Repression, Enabling Simultaneous Utilization of Sugars in Renewable Feedstocks

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1518-1530, June 2026.
ABSTRACT Yeast sugar transporters have highly evolved for preferential glucose transport, a significant roadblock for utilizing non‐glucose sugars in renewable feedstocks such as lignocellulosic biomass. To enable simultaneous transport of multiple sugars, native hexose transporters were replaced by SWEET7p from Arabidopsis thaliana in engineered ...
Nurzhan Kuanyshev, Degaulle Dai, Jungyeon Kim, Nam Kyu Kang, Ming‐Hsun Cheng, Vijay Singh, Yong‐Su Jin   +6 more
wiley   +1 more source

Engineering of CoA‐Acylating Butyraldehyde Dehydrogenase for Enhanced 1,3‐Butanediol Production in Escherichia coli

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1605-1614, June 2026.
ABSTRACT Microbial production of 1,3‐butanediol (1,3‐BDO) offers a renewable route to this versatile C4 chemical. However, the low performance of CoA‐acylating butyraldehyde dehydrogenase (Bld), which contains a catalytic cysteine, limits efficient production in recombinant Escherichia coli (E. coli).
Seunghyun Cho, Tayyab Islam, Sobia Islam, Junhak Lee, Sung Won Jung, Sunghoon Park   +5 more
wiley   +1 more source