Results 51 to 60 of about 11,662 (146)

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, Volume 293, Issue 12, Page 3565-3587, June 2026.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Application of an Acyl-CoA Ligase from Streptomyces aizunensis for Lactam Biosynthesis [PDF]

, 2017
ε-Caprolactam and δ-valerolactam are important commodity chemicals used in the manufacture of nylons, with millions of tons produced annually. Biological production of these highly valued chemicals has been limited due to a lack of enzymes that cyclize ω-
George Wang, Jay D. Keasling, Barajas, Jesus F., Baidoo, Edward E., Barajas, Jesus F, Jingwei Zhang, Baidoo, Edward E, Wang, George, Keasling, Jay D, Zhang, Jingwei, Burdu, Mehmet, Edward E. Baidoo, Mehmet Burdu, Jesus F. Barajas   +13 more
core   +1 more source

Production Performance and Ameliorative Effects of Switchgrass on Severely Saline‐Alkali Land in Coastal Areas of China

GCB Bioenergy, Volume 18, Issue 6, June 2026.
Switchgrass cultivation sustained biomass production while rapidly improving soil structure and reducing salinity in coastal saline‐alkali soils. These changes reshaped microbial communities through environmental filtering, establishing plant‐soil‐microbe feedbacks that support both bioenergy production and ecological restoration.
Aoxiang Chang, Bowen Li, Runli Li, Ting Wu, Qiang Guo, Xincun Hou, Cui Li, Mei Zheng, Honggang Chen, Yu Sun, Jinku Song, Yuejun Ma, Chunqiang Xing, Xiuyun Wan, Jinliang Chen, Chunqiao Zhao, Xifeng Fan, Zhenyu Fan   +17 more
wiley   +1 more source

Facile enzymic synthesis of caffeoyl CoA

, 1997
p-Hydroxycinnamic acid:CoA ligase (EC 6.2.1.12) was extracted from aspen xylem and its activity with several cinnamic acids was determined. The highest activity was found with p-hydroxycinnamic acid and the extract had reasonable activity with ferulic ...
Campbell, W.H., Campbell, Wilbur H., Meng, HuaBin   +2 more
core   +1 more source

Constitutive and inducible oleoresin defenses share genetic architectures and mechanisms in Pinus taeda

New Phytologist, Volume 250, Issue 5, Page 2966-2987, June 2026.
Summary The oleoresin defense system of loblolly pine (Pinus taeda) protects trees from insects and pathogens and is an important source of renewable biofuels and chemicals, but the genetic basis of oleoresin production is poorly understood. We characterized the genetic architecture of oleoresin flow, resin canal number, stem wood terpene content, and ...
Mallory M. Morgan, Jared Westbrook, Christopher Dervinis, Tania Quesada, Salvador Gezan, Robert Sykes, Timothy S. Johnson, Gabriela Madrid, Matthew Lane, Alice Townsend, Thomas A. Colquhoun, John M. Davis, Daniel Jacobson, Gary F. Peter   +13 more
wiley   +1 more source

Heterologous expression of the plant coumarate: CoA ligase in Lactococcus lactis

, 2005
[Aims]: To demonstrate the expression of coumarate : CoA ligase of Arabidopsis thaliana in Lactococcus lactis as a first step of cloning the vanillin pathway.[Methods and results]: The 4CL gene was amplified from a cDNA library of A.
Martínez-Cuesta, M. Carmen, Narbad, A., Gasson, M. J.   +2 more
core   +1 more source

The BAHD Acyltransferase Gene Family: Evolutionary Dynamics, Biochemical Mechanisms, and Roles in Plant Stress Adaptation

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4139-4158, June 2026.
BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar, Qiao Fei, Abdul Razzaq, Ayesha Siddiqua, Ayesha Naveed, M. Nasir Khan, Huma Saleem, Xuefei Jiang   +7 more
wiley   +1 more source

Coordinated regulation of 4-coumarate: CoA ligase and phenylalanine ammonia-lyase mRNAs in cultured plant cells

, 1981
Ragg H, Kuhn DN, Hahlbrock K. Coordinated regulation of 4-coumarate: CoA ligase and phenylalanine ammonia-lyase mRNAs in cultured plant cells. J. Biol. Chem.
Hahlbrock, Klaus, Ragg, Hermann, Kuhn, David N   +2 more
core  

DataSheet1_Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering.pdf

The CoA ligase from Metallosphaera sedula (MsACL) can be used for the chemoenzymatic synthesis of amides from carboxylic acids. In this CoA-independent conversion, the enzyme catalyzes the adenylation of a carboxylic acid with the help of ATP, followed ...
Dick B. Janssen (1566727), Chloé Lelièvre (18093016), Andy-Mark W. H. Thunnissen (8448201), Océane Touré (18093019), Anne Zaparucha (211219), Nikolas Capra (8448186), Aurélie Fossey-Jouenne (7618205), Carine Vergne-Vaxelaire (7419311)   +7 more
core   +1 more source

Aminoacyl-coenzyme A synthesis catalyzed by a CoA ligase from Penicillium chrysogenum

, 2011
Coenzyme A ligases play an important role in metabolism by catalyzing the activation of carboxylic acids. In this study we describe the synthesis of aminoacyl-coenzyme As (CoAs) catalyzed by a CoA ligase from Penicillium chrysogenum.
Bovenberg, Roel A.L., Janssen, Dick B., Dick B. Janssen, Jekel, Peter A.,, Hein J. Wijma, Janssen, Dick B.,, Jekel, Peter A., Koetsier, Martijn J., Bovenberg, Roel A. L., Koetsier, Martijn J.,, Martijn J. Koetsier, Wijma, Hein J.,, Peter A. Jekel, Bovenberg, Roel A.L.,, Wijma, Hein J., Roel A.L. Bovenberg   +15 more
core   +1 more source