Results 161 to 170 of about 846,453 (350)

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

open access: yesAdvanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi   +10 more
wiley   +1 more source

Tumor Microenvironment‐responsive Nanocatalyst for Targeted Chemodynamic Cancer Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
An Tumor microenvironment‐responsive nanocatalyst system composed of PLGA‐encapsulated Ca–Fe peroxide and polyarginine enables sustainable Fenton reaction in tumors. Low levels of H2O2 (50–100 µm) initiate the nanoparticle degradation, while polyarginine‐derived nitric oxide accelerates Fe3+ reduction, leading to self‐amplifying •OH generation for ...
Jun Ma, Jingjing Qiu, Shiren Wang
wiley   +1 more source

Printing and Rerouting of Elastic and Protease Responsive Shape Memory Hydrogel Filaments

open access: yesAdvanced Healthcare Materials, EarlyView.
A biofabrication strategy, Rerouting of Free‐Floating Suspended Hydrogel Filaments (REFRESH), is developed enabling the printing of highly elastic, reconfigurable protease‐responsive hydrogel filaments with shape memory properties. The filaments can be manually braided, knotted, and rerouted to create intricate cell‐laden 3D architectures, expanding ...
Philip Lifwergren   +10 more
wiley   +1 more source

3D Bioprinted Renal Constructs Using Kidney‐Specific ECM Bioink System on Kidney Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
A kidney‐specific bioink derived from decellularized porcine kidney tissue supports the encapsulation, viability, and maturation of human primary kidney cells within 3D bioprinted constructs. In vivo, it also promotes the recruitment of host renal progenitor cells, collectively enhancing structural and functional regeneration of renal tissue.
Gabriel Carreno‐Caleano   +4 more
wiley   +1 more source

Poly(hydroxy‐oxazolidone) Thermoplastic Elastomers for Safer, Greener and Customizable Blood‐Contacting Medical Devices

open access: yesAdvanced Healthcare Materials, EarlyView.
A poly(hydroxy‐oxazolidone) (PHOx) is synthesized from CO2‐based precursors, enabling the up‐cycling of this waste material. After synthesis, PHOx shows thermoplastic properties, and can therefore be processed by many temperature‐dependent techniques. PHOx is hemocompatible, anti‐adhesive, and biocompatible, which is demonstrated in vitro and in vivo ...
Sofia F. Melo   +11 more
wiley   +1 more source

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