Redirection of the Reaction Specificity of a Thermophilic Acetolactate Synthase toward Acetaldehyde Formation. [PDF]
PLoS ONE, 2016 Acetolactate synthase and pyruvate decarboxylase are thiamine pyrophosphate-dependent enzymes that convert pyruvate into acetolactate and acetaldehyde, respectively.
Maria Cheng +4 more
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Structure-Based Design of Acetolactate Synthase From Bacillus licheniformis Improved Protein Stability Under Acidic Conditions [PDF]
Frontiers in Microbiology, 2020 Catabolic acetolactate synthase (cALS) plays a crucial role in the quality of liquor because of its ability to catalyze the synthesis of the endogenous precursor product α-acetolactate of the aromatic compound tetramethylpyrazine (TTMP) and acetoin ...
Ting Zhao +8 more
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Impact of acetolactate synthase inactivation on 1,3-propanediol fermentation by Klebsiella pneumoniae. [PDF]
PLoS ONE, 2019 1,3-Propanediol (1,3-PDO) is an important compound that is mainly used in industry for polymer production. Fermentation of 1,3-PDO from glycerol by Klebsiella pneumoniae is accompanied by formation of 2,3-butanediol (2,3-BDO) as one of the main byproduct.
Sheng Zhou +6 more
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The Staphylococcus aureus α-Acetolactate Synthase ALS Confers Resistance to Nitrosative Stress [PDF]
Frontiers in Microbiology, 2017 Staphylococcus aureus is a worldwide pathogen that colonizes the human nasal cavity and is a major cause of respiratory and cutaneous infections. In the nasal cavity, S.
Sandra M. Carvalho +4 more
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Characterization and Regulation of the Acetolactate Synthase Genes Involved in Acetoin Biosynthesis in Acetobacter pasteurianus. [PDF]
Foods, 2021 Acetoin is an important aroma-active chemical in cereal vinegars. Acetobacter pasteurianus was reported to make a significant contribution to acetoin generation in cereal vinegars.
Zhao J +5 more
europepmc +2 more sources
Differential expression of genes associated with non-target site resistance in Poa annua with target site resistance to acetolactate synthase inhibitors. [PDF]
Pest Manag Sci, 2021 BACKGROUND Poa annua is a pervasive grassy, self‐pollinating, weed that has evolved resistance to 10 different herbicide modes‐of‐action, third most of all weed species. We investigated constitutive overexpression of genes associated with non‐target site
Laforest M +7 more
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Identification of acetolactate synthase resistant Amaranthus retroflexus in Ukraine
Regulatory Mechanisms in Biosystems, 2022 The problem of weed resistance to herbicides has become very important in the last decade and threatens to dramatically reduce the productivity and profitability of modern crop production. Herbicides – ALS inhibitors dominate among current herbicides and
L. M. Mykhalska, V. V. Schwartau
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Unravelling the effect of two herbicide resistance mutations on acetolactate synthase kinetics and growth traits. [PDF]
J Exp Bot, 2020 The herbicide resistance mutations Pro-197-Tyr and Trp-574-Leu have contrary effects on both pyruvate substrate binding and maximum reaction velocity of acetolactate synthase, highly correlated with the cost of resistance.
Zhao N +5 more
europepmc +2 more sources
A Trp574-Leu substitution confers resistance to three classes of acetolactate synthase inhibitors in Australian brome grass (Bromus diandrus). [PDF]
Pest Manag SciTarget‐site based imidazolinone resistance in brome grass was found to be conferred by a mutation at position 574 in the ALS gene and to severely impact the efficacy of the herbicide Intervix®, a co‐formulation of imazamox and imazapyr. Abstract BACKGROUND Brome grass (Bromus diandrus) is a prevalent weed in southern Australian cropping regions which ...
Busi R +5 more
europepmc +2 more sources
HERBICIDES THAT INHIBIT ACETOLACTATE SYNTHASE [PDF]
Frontiers of Agricultural Science and Engineering, 2022 Thierry LONHIENNE, Mario Daniel GARCIA, Yu Shang LOW, Luke W. GUDDAT
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