Results 31 to 40 of about 323,458 (316)

DISSOLUTION TEST IN QUALITY ASSESSMENT OF TABLETS CONTAINING 11-DEOXYMISOPROSTOL

Кубанский научный медицинский вестник, 2018
Aim. Development of the dissolution test method of 11-deoxymisoprostol tablets.Materials and methods. The research was carried out on a "paddle apparatus".
A. A. FEDOTOVA, A. G. YALKAEV, V. A. KATAEV, R. A. KHALIKOV, F. Kh. KILDIYAROV   +4 more
doaj   +1 more source

Densities and excess molar volumes of the binary systems of the ionic liquid trihexyl(tetradecyl)phosphonium bromide mixed with acetonitrile or tetrahydrofuran at temperatures from 293.15 to 313.15 K

Frontiers in Physics, 2023
Experimental densities and excess molar volumes of two binary mixtures composed of the ionic liquid trihexyl(tetradecyl)phosphonium bromide ([THTDP][Br]) mixed with acetonitrile (ACN) or tetrahydrofuran (THF) are reported in this work.
Octavio Elizalde-Solis, Abel Zúñiga-Moreno, Luis E. Camacho-Camacho, Ricardo García-Morales, Sandro González-Arias, Francisco J. Verónico-Sánchez   +5 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Facile rearrangement of push-pull 5-substituted 4-oxothiazolidines induced by pyridinium hydrobromide perbromide under homogeneous reaction conditions [PDF]

Journal of the Serbian Chemical Society, 2004
Pyridinium hydrobromide perbromide (PHBP) is a highly efficient reagent for the conversion of 5-substituted-2-alkylidene-4-oxothiazolidine derivatives to the corresponding thiazolidines with two fully delocalized exocyclic double bonds at the C(2) and C ...
ZDRAVKO DZAMBASKI, MARIJA BARANAC, RADE MARKOVIC   +2 more
doaj  

Chemical synthesis of oligonucleotides using acetone as a washing solvent

BioTechniques, 2009
Acetone is being proposed as the main washing solvent during automated synthesis of oligonucleotides to reduce acetonitrile usage in the assembly process and endure the impact of global acetonitrile shortage.
Paul Gaytán
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

2-(2-Nitrophenylsulfinyl)acetonitrile [PDF]

Acta Crystallographica Section E Structure Reports Online, 2013
In the title compound, C8H6N2O3S, the dihedral angle between the nitro group and the benzene ring is 6.76 (9)°. The bond-angle sum at the S atom is 308.1°. In the crystal, mol-ecules are linked by C-H⋯O hydrogen bonds to generate (010) sheets. The crystal studied was found to be a racemic twin.
Sabrina Benmebarek, Mhamed Boudraa, Sofiane Bouacida, Hocine Mérazig   +3 more
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

FLAVONOIDS IN THE GRASS OF TRIBULUS TERRESTRIS L.

Фармация и фармакология (Пятигорск), 2015
The article presents active parts of Tribulus terrestris L. as a perspective sample for study. We have provided an example of flavo-noids determination with high-performance liquid chromatography / MS at the Waters Acquility chromatographer with tandem ...
P. E. Khudenko, S. L. Morokhina, D. M. Popov, N. S. Tereshina   +3 more
doaj   +1 more source