Results 171 to 180 of about 343,067 (338)

Congenital Myasthenic Syndrome Caused by Decreased Agonist Binding Affinity Due to a Mutation in the Acetylcholine Receptor ε Subunit [PDF]

, 1996
Kinji Ohno, Hai-Long Wang, Margherita Milone, Nina Bren, Joan M. Brengman, Satoshi Nakano, Polly A. Quiram, J. Ned Pruitt, Steven M. Sine, Andrew G. Engel   +9 more
openalex   +1 more source

Spirocyclic Diamine Scaffolds for Medicinal Chemistry

Helvetica Chimica Acta, EarlyView.
Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel, Alejandro Flores, Maedeh Darsaraee, Jean‐Louis Reymond   +3 more
wiley   +1 more source

Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens [PDF]

, 2016
Jichun Zhang, Wei Yao, Qian Ren, Chun Yang, Chao Dong, M Ma, Jin Wu, Kenji Hashimoto   +7 more
openalex   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Differential Effects of Quercetin and Quercetin Glycosides on Human α7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents

, 2016
Byunghwan Lee, Sun-Hye Choi, Hyeon‐Joong Kim, Seokwon Jung, Sung‐Hee Hwang, Mi-Kyung Pyo, Hyewhon Rhim, Hyoung‐Chun Kim, Ho-Kyoung Kim, Sang‐Mok Lee, Seung‐Yeol Nah   +10 more
openalex   +2 more sources

Neuronal nicotinic acetylcholine receptors are important targets for alcohol reward and dependence [PDF]

, 2014
Jie Wu, Ming Gao, Devin H. Taylor
openalex   +1 more source

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, EarlyView.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source

Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation

, 2018
Marta Quadri, Almin Silnović, Carlo Matera, Nicole A. Horenstein, Clare Stokes, Marco De Amici, Roger L. Papke, Clelia Dallanoce   +7 more
openalex   +2 more sources

Acetylcholine Receptor (AChR) Clustering Is Regulated Both by Glycogen Synthase Kinase 3β (GSK3β)-dependent Phosphorylation and the Level of CLIP-associated Protein 2 (CLASP2) Mediating the Capture of Microtubule Plus-ends [PDF]

, 2014
Sreya Basu, Stefan Sladecek, Hayley Pemble, Torsten Wittmann, Johan A. Slotman, Wiggert A. van Cappellen, Hans-Rudolf Brenner, Niels Galjart   +7 more
openalex   +1 more source

Wuda Granule Improves the Gastrointestinal Motility via Gut‐Brain Axis in Beagle Dogs

iMetaMed, EarlyView.
Stress sensors were implanted in the gastric body, sinus, duodenum, jejunum, and colon of beagle dogs to record gastrointestinal motility. Gastrointestinal contractile motility was assessed before and after the lateral ventricular injection of Wuda granule, intravenous atropine instillation, and bilateral cervical vagotomy.
Zhi Jiang, Xing Li, Qicheng Chen, Zhiqiang Chen, Lixing Cao, Hailin Tang   +5 more
wiley   +1 more source