Results 181 to 190 of about 180,246 (294)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

open access: yesMed Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin   +8 more
wiley   +1 more source

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou   +6 more
wiley   +1 more source

Protocol for the measurement of secreted acetylcholine in the lumen of mouse intestine using LC-MS. [PDF]

open access: yesSTAR Protoc
Turtoi E   +7 more
europepmc   +1 more source

Reading Difficulty of Online Patient Education Materials for Procedures in Dermatology

open access: yes
JEADV Clinical Practice, EarlyView.
Elizabeth Botto   +3 more
wiley   +1 more source

Microstructural Changes in the Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disorders

open access: yesMovement Disorders, EarlyView.
Abstract Background Excessive daytime sleepiness (EDS) is a disabling symptom of Lewy body disorders (LBD). The hypothalamus is a key sleep–wake regulator and is involved in Lewy pathology, but its contribution to EDS in LBD remains unclear. Objectives To use diffusion‐weighted magnetic resonance imaging (MRI) to detect hypothalamic microstructure and ...
Jesse S. Cohen   +8 more
wiley   +1 more source

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