Results 211 to 220 of about 124,177 (265)

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Serum cystatin C as a potential biomarker for generalized acetylcholine receptor antibody-positive myasthenia gravis. [PDF]

Front Immunol
He D, Zhong H, Jin L, Chen R, Wu Z, Zhao R, Huan X, Yan C, Song J, Xi J, Zhao C, Zhu S, Luo S.   +12 more
europepmc   +1 more source

Effect of the Arg16Gly β2‐Adrenergic Receptor Polymorphism on Long‐Term Mepolizumab Response and Clinical Remission in Severe Eosinophilic Asthma: A Genotype‐Stratified, Multicenter Study

Allergy, EarlyView.
This study examines the association between the rs1042713 (Arg16Gly) polymorphism of the β2‐adrenergic receptor and the risk of severe eosinophilic asthma, as well as its influence on mepolizumab long‐term effectiveness and clinical remission. The Arg16 allele is associated with increased risk of severe disease and potentially diminished long‐term ...
Santi Nolasco, Evelina Fagone, Raffaele Campisi, Andrea Portacci, Giulia Scioscia, Corrado Pelaia, Angelantonio Maglio, Claudio Candia, Vitaliano Nicola Quaranta, Isabella Carrieri, Alessandro Saglia, Alessandro Vatrella, Girolamo Pelaia, Carlo Vancheri, Maria Pia Foschino Barbaro, Maria D'Amato, Giovanna Elisiana Carpagnano, Nunzio Crimi, Claudia Crimi, on behalf of the Southern Italy Network on Severe Asthma Therapy, Rossella Intravaia, Morena Porto, Pietro Impellizzeri, Maria Provvidenza Pistorio, Fabio Vignera, Andrea Alessia Nardo, Concetta Giannì, Silvano Dragonieri, Flogerta Sana, Valeria Pezzuto, Santina Ferulli, Massimo Triggiani, Roberta Parente, Pasquale Tondo, Piera Soccio, Donato Lacedonia, Luigi Ciampo, Antonio Franzese, Valeria Longobardi   +38 more
wiley   +1 more source

Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages. [PDF]

Invest Ophthalmol Vis Sci
Zhou X, Wu Y, Zhang Y, Chu B, Yang K, Hong J, He Y.   +6 more
europepmc   +1 more source

Effect of Functional Electrical Stimulation Combined With Physical Exercise on Electron Transport Chain Activity in Peripheral Blood Cells of Stroke Patients

Artificial Organs, EarlyView.
Stroke induces mitochondrial dysfunction and motor disorders. FES combined with physical exercises can help restore mitochondrial function by regulating the formation of reactive oxygen species and, consequently, contributing to functional recovery. ABSTRACT Background Stroke is commonly accompanied by motor disorders secondary to the initial injury ...
A. Larrea, A. Martín‐Odriozola, E. Astigarraga, C. Rodríguez‐de‐Pablo, G. Barreda‐Gómez, M. Torrecilla   +5 more
wiley   +1 more source

α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer. [PDF]

Biomolecules
Feng X, Tian Y, Guo X, Lei JH, Yu J, Zheng C, Chen M, Ding RB, Kwok HF, Luo S, Bao J.   +10 more
europepmc   +1 more source

Tau Triggers Tear Secretion by Interacting with Muscarinic Acetylcholine Receptors in New Zealand White Rabbits

, 2014
Alejandro Martínez‐Águila, Begoña Fonseca, Félix Hernández, Miguel Díaz‐Hernández, Jesús Ávila, Jesús Pintor   +5 more
openalex   +2 more sources

Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion

Artificial Organs, EarlyView.
This study aimed to investigate the influence of warm ischemic injury on renal vascular responsiveness to vasoactive drugs during normothermic machine perfusion (NMP). We found that the vascular responses to dopamine and norepinephrine could be used as objective indicators to assess kidney viability during NMP.
Isa M. van Tricht, Baran Ogurlu, Silke S. M. Wolfswinkel, Henri G. D. Leuvenink, Cyril Moers   +4 more
wiley   +1 more source

Electrical Stimulation of Denervated Muscle: A Narrative Review

Artificial Organs, EarlyView.
This review explores existing strategies for stimulating denervated muscle following lower motor neuron injury, including direct electrical stimulation of the muscle and artificial reinnervation to enable more comfortable and efficient indirect functional muscle stimulation.
Linshan Chu, Jonathan C. Jarvis, Brian J. Andrews, James J. FitzGerald   +3 more
wiley   +1 more source

Correlation of Antimuscarinic Acetylcholine Receptor Antibody Titers With Pemphigus Disease Activity at Baseline and Following Phase I Pulse Therapy. [PDF]

Cureus
Behera B, Palit A, Sahu S, Sahoo SS, Sethy M.   +4 more
europepmc   +1 more source