Results 221 to 230 of about 217,964 (360)

Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell, Amin Rostami‐Hodjegan, Guy Meno‐Tetang, Donald E. Mager, Kayode Ogungbenro   +4 more
wiley   +1 more source

A New Era of Muscarinic Acetylcholine Receptor Modulators in Neurological Diseases, Cancer and Drug Abuse. [PDF]

Pharmaceuticals (Basel)
Tsimpili H, Zoidis G.
europepmc   +1 more source

Nipocalimab Dose Selection in Generalized Myasthenia Gravis

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
Model‐Informed Nipocalimab Dose Selection for Generalized Myasthenia Gravis. ABSTRACT Nipocalimab is a fully human immunoglobulin G (IgG)1 monoclonal antibody (mAb) designed to selectively block the IgG binding site of neonatal fragment crystallizable receptor (FcRn) to inhibit IgG recycling and decrease circulating IgG, including pathogenic IgG ...
Belén Valenzuela, Martine Neyens, Yaowei Zhu, Sindhu Ramchandren, Anne‐Gaëlle Dosne, Jocelyn H. Leu, Ruben Faelens, Leona E. Ling, Juan‐José Pérez‐Ruixo   +8 more
wiley   +1 more source

Research progress in myocardial function and diseases related to muscarinic acetylcholine receptor (Review). [PDF]

Int J Mol Med
Shen C, Zuo Q, Shao Z, Lin Y, Chen S.
europepmc   +1 more source

Mechanism of acetylcholine release: possible involvement of presynaptic muscarinic receptors in regulation of acetylcholine release and protein phosphorylation.

, 1979
D. M. Michaelson, Sofia Avissar, Yoel Kloog, Mordechai Sokolovsky   +3 more
openalex   +1 more source

RELATIONSHIPS BETWEEN CHEMICAL STRUCTURE AND AFFINITY FOR POSTGANGLIONIC ACETYLCHOLINE RECEPTORS OF THE GUINEA‐PIG ILEUM [PDF]

, 1974
F. B. Abramson, R. B. BARLOW, Fiona M. Franks, Jeremy D. Pearson   +3 more
openalex   +1 more source

Reagentless Real‐Time ATP Monitoring with New DNA Aptamers

Small, EarlyView.
A new aptamer is discovered via in vitro selection that binds to adenosine triphosphate (ATP) with high affinity (KD = 0.7 µm) and rejects closely related analogs including adenosine diphosphate (ADP), adenosine monophosphate (AMP), and adenosine. A fluorescent molecular beacon based on the aptamer enables continuous analyte monitoring in cell culture ...
Adara Bacon, Obtin Alkhamis, Caleb Byrd, Jacob Perry, Juan Canoura, Yi Xiao   +5 more
wiley   +1 more source

Genetic and pharmacological targeting of nicotinic acetylcholine receptor action blocks tumor progression in mouse models of breast cancer. [PDF]

J Immunol
Heard MA, Qian J, Sayeed S, Mechlowicz S, Zhang Q, Yeluri S, Pool K, Yamane R, Morris GP, Eliceiri BP.   +9 more
europepmc   +1 more source

Multi‐Channel Neural Interface for Neural Recording and Neuromodulation

Small Methods, EarlyView.
This review highlights recent advances in multi‐channel neural interface technologies, covering both high‐resolution electrophysiological recording systems and multifunctional platforms with integrated capabilities. It also discusses innovations in structure and materials for reduced invasiveness, state‐of‐the‐art data analysis, including machine ...
Eunmin Kim, Won Gi Chung, Enji Kim, Myoungjae Oh, Joonho Paek, Taekyeong Lee, Dayeon Kim, Seung Hyun An, Sumin Kim, Jang‐Ung Park   +9 more
wiley   +1 more source

Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor. [PDF]

Mol Pharmacol
Chen K, Park E, Abd-Elrahman KS.
europepmc   +1 more source