Results 251 to 260 of about 217,964 (360)

Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease‐Like Brain Transcriptomic Signatures in AppNL‐G‐F Mice

Aging Cell, EarlyView.
Choline‐protected genes correlated with clinical dementia rating, inflammation, and tauopathy in human AD samples, suggesting that adequate choline intake could be a preventive strategy for Alzheimer's disease (AD). ABSTRACT Alzheimer's disease (AD)—the leading cause of dementia—has no cure, inadequate treatment options, and a limited understanding of ...
Thomas A. Bellio, Andre Krunic, Mary S. Campion, Rohan Dupaguntla, Adam Labadorf, Thor D. Stein, Honghuang Lin, Tiffany J. Mellott, Jan K. Blusztajn   +8 more
wiley   +1 more source

Design, Synthesis, and Evaluation of a New Fluorescent Ligand for the M₂ Muscarinic Acetylcholine Receptor. [PDF]

ACS Med Chem Lett
Szabó R, Szepesi Kovács D, Kiss DJ, Yazdi ZN, Tóth AD, Brea J, Loza MI, Meszéna D, Wittner L, Ulbert I, Volk B, Hunyady L, Keserű GM.   +12 more
europepmc   +1 more source

Peri‐ and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice

Aging Cell, EarlyView.
Postnatal high fat (HF) feeding negatively impacts executive function in both adult and aged mice, but consumption of the same diet during the perinatal period only is beneficial in older age. Maternal HF diet is associated with increased cholinergic innervation of the prefrontal cortex of young, but not aged, offspring.
Laura Contu, Adam Johnson, Christopher J. Heath, Cheryl A. Hawkes   +3 more
wiley   +1 more source

The role of complement in the immunopathogenesis of acetylcholine receptor antibody-positive generalized myasthenia gravis: bystander or key player? [PDF]

Front Immunol
Michailidou I, Patsiarika A, Kesidou E, Boziki MK, Parisis D, Bakirtzis C, Chroni E, Grigoriadis N.   +7 more
europepmc   +1 more source

Muscle Regeneration Can Be Rescued in a Telomerase Deficient Zebrafish Model of Ageing by MMP Inhibition

Aging Cell, EarlyView.
Inhibition of MMP9/13 restores both muSC behaviour and regeneration, while macrophage ablation enhances muSC recruitment to the injury, but fails to improve muscle repair in telomerase‐deficient zebrafish larvae. ABSTRACT Ageing progressively impairs skeletal muscle regeneration, contributing to reduced mobility and quality of life. While the molecular
Yue Yuan, Carlene Dyer, Robert D. Knight
wiley   +1 more source

Development of a refined experimental mouse model of myasthenia gravis with anti-acetylcholine receptor antibodies. [PDF]

Front Immunol
You A, Lippens LS, Fayet OM, Maillard S, Betemps L, Grondin A, Vilquin JT, Dragin N, Le Panse R.   +8 more
europepmc   +1 more source

Brain DNA Methylation Atlas of AppNL‐G‐F Alzheimer's Disease Model Mice Across Age and Region Reveals Choline‐Induced Resilience

Aging Cell, EarlyView.
Brain DNA methylation drives abnormal gene expression in AppNL‐G‐F mice. Perinatal choline supplementation may promote resilience to synaptic dysfunction through modulation of DNA methylation. ABSTRACT Alzheimer's disease (AD) is the most common type of dementia.
Andre Krunic, Thomas A. Bellio, Benjamin Z. Cohen, Adam Labadorf, Thor D. Stein, Honghuang Lin, Tiffany J. Mellott, Jan K. Blusztajn   +7 more
wiley   +1 more source

Human α10 nicotinic acetylcholine receptor subunits assemble to form functional receptors. [PDF]

J Biol Chem
Tekarli B, Azam L, Hone AJ, McIntosh JM.
europepmc   +1 more source

Effect of varenicline on major adverse liver outcomes in alcohol‐associated liver disease: An exploratory analysis

Alcohol, Clinical and Experimental Research, EarlyView.
This real‐world study assessed whether varenicline improves outcomes in patients with ALD and AUD. Using data from a large electronic health record network, 1278 matched patients were analyzed. Varenicline use was associated with reduced all‐cause mortality and hepatic encephalopathy compared with FDA‐approved AUD therapies (acamprosate or naltrexone),
Pojsakorn Danpanichkul, Yanfang Pang, Donghee Kim, Thanathip Suenghataiphorn, Donghyun Ko, Andrew F. Ibrahim, Vitchapong Prasitsumrit, Kwanjit Duangsonk, Mazen Noureddin, Karn Wijarnpreecha, Suthat Liangpunsakul   +10 more
wiley   +1 more source

Impacts of perinatal nicotine exposure on nicotinic acetylcholine receptor expression and glutamatergic synaptic transmission in the mouse auditory brainstem. [PDF]

J Physiol
Wollet M, Hernandez A, Nip K, Ginsburg B, Pugh JR, Kim JH.   +5 more
europepmc   +1 more source