Results 291 to 300 of about 217,964 (360)

Efficacy and safety of an alpha 7-nicotinic acetylcholine receptor agonist, VQW-765, in subjects with performance anxiety: randomised, double-blind, placebo-controlled trial. [PDF]

Br J Psychiatry
He Y, Polymeropoulos CM, Mohrman MA, Truslow SO, Xiao C, Wu Y, Birznieks G, Polymeropoulos MH.   +7 more
europepmc   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Endogenous muscarinic acetylcholine receptor signaling blunts α₁-adrenergic vasoconstriction during higher-intensity handgrip exercise in humans. [PDF]

Am J Physiol Regul Integr Comp Physiol
Terwoord JD, Dinenno FA, Richards JC, Hearon CM.   +3 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Elucidation of the zinc binding site in KCNQ channels

British Journal of Pharmacology, EarlyView.
Background and Purpose KCNQ1‐5 (Kv7.1–7.5) are members of a family of voltage‐gated potassium channels with prominent function in the nervous and cardiovascular systems and in epithelia. KCNQ channels are activated by intracellular free zinc, but the molecular mechanism of this effect is poorly understood and zinc binding sites within KCNQ channels are
Shuo Zhang, Xinhe Yang, Meng Yang, Yixue Cao, Sai Shi, Nikita Gamper, Haixia Gao   +6 more
wiley   +1 more source

Synergistic effects of memantine and alpha7 nicotinic acetylcholine receptor agonist PHA-543613 to improve memory of aged rats. [PDF]

Int J Neuropsychopharmacol
Bruszt N, Bali ZK, Nagy LV, Bodó K, Engelmann P, Hernádi I.   +5 more
europepmc   +1 more source

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats

British Journal of Pharmacology, EarlyView.
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj, Saadet Inan, Guo‐Hua Bi, Sonita Wiah, George Adamson, Allen B. Reitz, Zheng‐Xiong Xi, Scott M. Rawls   +7 more
wiley   +1 more source

Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition. [PDF]

Sci Rep
Saternos HC, Forero KV, Meqdad MA, Buqaileh R, Sunderman CL, Gallagher G, Messer WS, Mohieldin AM, Mucci CA, Kumariya S, Osman IA, Burkett JP, AbouAlaiwi WA.   +12 more
europepmc   +1 more source

Response – Building on existing knowledge and redefining rather than abandoning the well‐established ‘clinical high risk for psychosis’ prevention paradigm

Child and Adolescent Mental Health, EarlyView.
We appreciate the commentary by Tiffin and Kelleher on our systematic review and meta‐analysis. The CHR‐P paradigm remains one of the most established preventive approaches in mental health. While concerns have been raised regarding the clinical utility of the CHR‐P paradigm, its implementation in specialized services worldwide supports its relevance ...
Gonzalo Salazar de Pablo, Claudia Aymerich, Grace Frearson, Javier de Otazu Olivares, Ana Catalan   +4 more
wiley   +1 more source

Exploring the clinical significance of anti-acetylcholine receptor antibody titers, changes, and change rates in Myasthenia Gravis. [PDF]

Front Neurol
Luo L, Zhu X, Wen C, Guo Y, Yang J, Wei D, Yu P, Wan M.   +7 more
europepmc   +1 more source