Results 91 to 100 of about 68,584 (292)

Effect of Silica Surface on Hydrolysis of Acetylsalicylic Acid: Theoretical Simulation

Хімія, фізика та технологія поверхні, 2011
Using methods of quantum chemistry, the mechanisms of hydrolytic degradation of acetylsalicylic acid have been considered in aqueous solution at pH values from 2 to 4 and from 4 to 8.5 as well as those involving silica surface.
E. M. Demianenko
doaj  

Optimization of a drug simultaneous dissolution and permeability screening method

Saúde & Tecnologia, 2014
The goal of this research project was the optimization of a method for simultaneously screen the dissolution rate and the permeability of drug formulations across Polyvinylidene Fluoride membranes, using a bilateral flow cell.
Pedro Ferreira, Hugo Serra, João Mário Pedro, Anabela Graça, Ana Luísa Simplício   +4 more
doaj   +1 more source

Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season [PDF]

, 2010
Background and Objective Air temperature changes are associated with increased cardiovascular and respiratory risk, but the roles of inflammatory and coagulation markers are not well understood.
Breitner, Susanne, Frampton, Mark W., Hampel, Regina, Koenig, Wolfgang, Peters, Annette, Phipps, Richard P., Rückerl, Regina, Schneider, Alexandra, Wichmann, Heinz-Erich   +8 more
core   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Drug-Excipient Compatibility Studies in Formulation Development: Current Trends and Techniques [PDF]

, 2015
The safety, efficacy, quality and stability of a formulation are the cornerstones of any new drug development process. In order to consistently maintain these attributes in a finished dosage form, it is important to have a comprehensive understanding of ...
Dave, Vivek S, Haware, Rahul V., Popielarczyk, Michael, Sangave, Nikhil A., Sayles, Matt   +4 more
core   +1 more source

Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N‐ERD Patients

Clinical &Experimental Allergy, EarlyView.
Dupilumab therapy reduced elevated type 2 cytokine responses post‐ASA provocation in N‐ERD patients, independent of ASA tolerance, and revealed novel mechanistic insights by modulating acute type 2 immunity. Transcriptomic analysis showed concurrent downregulation of lipid and peroxisome pathways during ASA challenge in N‐ERD patients after 24 weeks of
Julia Eckl‐Dorna, Christina Morgenstern, Katharina Poglitsch, Tamara Arnoldner, Katharina Gangl, Tina J. Bartosik, Nicholas J. Campion, Aldine Tu, Victoria Stanek, Sven Schneider, Christine Bangert   +10 more
wiley   +1 more source

Acetylation of albumin by low doses of aspirin [PDF]

, 1981
Aspirin has a variety of pharmacologic actions, which are expressed at different doses of the drug. An effect on platelet function occurs at very low doses of aspirin (1,2).
Blazer-Yost, Bonnie, Burch, John W.
core   +1 more source

Exploring Brain Parenchymal Changes in Acromegaly: Focus on White Matter Hyperintensities

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Acromegaly is a rare chronic disease caused by excessive secretion of growth hormone. Even with biochemical control, hormonal imbalance may lead to cerebral changes. This study aimed to evaluate the presence of white matter hyperintensities (WMHs) in patients with acromegaly.
Denise Costa, Giada Giuliani, Valentina Martines, Chiara Pellicano, Valeria Mercuri, Vittorio Di Piero, Patrizia Gargiulo, Camilla Virili   +7 more
wiley   +1 more source

Clinical trial protocol of the ASTER trial: a double-blind, randomized, placebo-controlled phase III trial evaluating the use of acetylsalicylic acid (ASA) for enhanced early detection of colorectal neoplasms

BMC Cancer, 2018
ᅟ Immunochemical fecal occult blood tests (iFOBTs) are increasingly used for colorectal cancer (CRC) screening. In our preceding observational study, sensitivity for detecting advanced colorectal neoplasms by iFOBT was 70.8% among users of low-dose ...
Kaja Tikk, David Czock, Walter E. Haefeli, Annette Kopp-Schneider, Hermann Brenner   +4 more
doaj   +1 more source

Amniotic Fluid Ingestion Enhances\ud Opioid-Mediated But Not\ud Nonopioid-Mediated Analgesia [PDF]

, 1990
Ingestion of amniotic fluid or placenta by rats has been shown to enhance several types of opioid-mediated analgesia: that induced by morphine, footshock, vaginal/cervical stimulation, and late pregnancy.
Barton, Debra, Kristal, Dr. Mark B., Tarapacki, J. A.   +2 more
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