Results 171 to 180 of about 124,205 (336)

Functional validation of a white pupae minimal gene construct in Ceratitis capitata (Diptera: Tephritidae)

open access: yesInsect Science, EarlyView.
An intronless version of the white pupae (wp) gene was engineered to restore the wild type brown puparium color in white pupae phenotype mutants of the Mediterranean fruit fly, Ceratitis capitata. Functionality of the minimal gene version (mini‐wp) was verified in vivo, as one copy of mini‐wp successfully restored the wild type phenotype in homozygous ...
Lucas Henrique Figueiredo Prates   +4 more
wiley   +1 more source

‘Standard KAMs’, ‘Canary KAMs’, and ‘Naughty KAMs’: A Typology of Key Audit Matters to Explain Their Value Relevance

open access: yesAbacus, EarlyView.
This paper develops a framework for understanding how key audit matters (KAMs) can be factored into investors’ risk assessments. Detailed interviews with seasoned investors representing international and regional asset managers and owners confirm that the number and type of reported KAMs are not ‘priced’ directly.
Warren Maroun   +2 more
wiley   +1 more source

Point‐Of‐Care Respiratory Diagnosis and Antibiotic Utilization in the Emergency Department: A Prospective Evaluation of Multiplex PCR

open access: yesAcademic Emergency Medicine, EarlyView.
ABSTRACT Objectives Rapid multiplex point‐of‐care (POC) PCR tests may reduce unnecessary antibiotic prescribing by quickly identifying viral etiologies in patients with acute respiratory infections (ARI). We evaluated the impact of a rapid (~15 min) multiplex PCR test on antibiotic prescribing, provider confidence, patient satisfaction, and emergency ...
Andrew C. Meltzer   +11 more
wiley   +1 more source

Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.

open access: yesACS Medicinal Chemistry Letters, 2018
Xueyang Jiang   +8 more
semanticscholar   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

open access: yesActa Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian   +3 more
wiley   +1 more source

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): baseline data from day surgery practice in the UK

open access: yesAnaesthesia, EarlyView.
Summary Introduction Most patients undergoing elective surgery in the UK are discharged from hospital on the same day. Despite this, there is a lack of UK patient‐centred outcome measures relating to quality of recovery, pain and analgesic use. The POPPY study was a UK‐wide prospective, observational study measuring short‐ and longer‐term patient ...
Martha Belete   +8 more
wiley   +1 more source

Less-developed countries and innovation in health: notes and data about the Brazilian case [PDF]

open access: yes
This communication discusses the specificity of health innovation in a lessdeveloped country, investigating the Brazilian case. To evaluate the specificity of the Brazilian system, this communication presents data about employment, expenditures ...
Eduardo da Motta e Albuquerque   +1 more
core  

Ligand and structure-based toxicological assessment of (thio)semicarbazones on cholinesterases. [PDF]

open access: yesJ Comput Aided Mol Des
de Sousa DS   +7 more
europepmc   +1 more source

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