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Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis [PDF]
International Journal of Molecular Sciences, 2021 Acetylcholinesterase (AChE) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. There is a search for new compounds that can prevent the occurrence of neurodegenerative diseases and slow down their course.
Łucja Justyna Walczak-Nowicka +1 more
exaly +4 more sources
Molecular Genetic Studies on Honeybees in Response to Some Environmental Stresses [PDF]
Arab Universities Journal of Agricultural Sciences, 2023 The honeybee, Apis mellifera, is a widespread pollinator insect. Colony collapse disorder (CCD) has recently caused a significant decline in honeybee numbers worldwide.
Rehab Mohamed +4 more
doaj +1 more source
Cardiovascular Complications of Acetylcholinesterase Inhibitors in Patients with Alzheimer’s Disease: A Narrative Review [PDF]
Annals of Geriatric Medicine and Research, 2021 While acetylcholinesterase inhibitors are used to treat a wide range of patients with Alzheimer’s disease, acetylcholinesterase inhibitor use has also been associated with a variety of cardiovascular complications, including bradycardia and syncope ...
Sara Young, Enoch Chung, Michael A. Chen
doaj +1 more source
Readthrough acetylcholinesterase is increased in human liver cirrhosis. [PDF]
PLoS ONE, 2012 BACKGROUND & AIMS: There have been many studies on plasma butyrylcholinesterase in liver dysfunction. However, no data is available about acetylcholinesterase in human cirrhosis, although profound changes have been described in cirrhotic rat models ...
María-Salud García-Ayllón +4 more
doaj +1 more source
Molecules, 2021 Isoquinoline alkaloids may have a wide range of pharmacological activities. Some of them have acetylcholinesterase activity inhibition. Nowadays, neurodegenerative disorders such as Alzheimer’s disease have become a serious public health problem ...
Tomasz Tuzimski, Anna Petruczynik
doaj +1 more source
Bioinformatics and Biology Insights, 2022 The inhibition of acetylcholinesterase plays a vital role in the treatment of Alzheimer disease. This study aimed to explore the acetylcholinesterase inhibition potential of Phyllanthus amarus and its phytoconstituents through an in vitro and in silico ...
Kolade O Faloye +10 more
doaj +1 more source
Acetylcholinesterase in Thrombocytes [PDF]
Nature, 1952 IT has been shown recently1 that the thrombocytes of rat blood contain a cholinesterase having properties similar to the acetylcholinesterase found in erythrocytes. The present communication gives evidence for the presence of an acetylcholinesterase in the thrombocytes of other animals.
K B, AUGUSTINSSON +3 more
openaire +2 more sources
Indonesian Journal of Chemistry, 2020 Structure-based virtual screening protocol to identify potent acetylcholinesterase inhibitors was retrospectively validated. The protocol could be employed to examine the potential of designed compounds as novel acetylcholinesterase inhibitors.
Vivitri Dewi Prasasty +1 more
doaj +1 more source
Acetylcholinesterase Involvement in Apoptosis [PDF]
Frontiers in Molecular Neuroscience, 2012 To date, more than 40 different types of cells from primary cultures or cell lines have shown AChE expression during apoptosis and after the induction apoptosis by different stimuli. It has been well-established that increased AChE expression or activity is detected in apoptotic cells after apoptotic stimuli in vitro and in vivo, and AChE could be ...
Zhang, Xue-Jun, Greenberg, David S.
openaire +3 more sources
Heliyon, 2023 Neurodegenerative disorders, caused by progressive neuron loss, are a global health issue. Among the various factors implicated in their pathogenesis, dysregulation of acetylcholinesterase activity has been recognized as a key contributor ...
Shehla Shoukat +8 more
doaj +1 more source