Results 41 to 50 of about 85,087 (299)

One‐Pot Biphasic Photocatalytic CO2‐to‐Carbonylation Cascades

Angewandte Chemie, EarlyView.
Bioinspired biphasic compartmentalization enables one‐pot cascades where photocatalytic CO2 reduction generates CO for carbonylative cross‐couplings to synthesize complex organic products, including a pharmaceutical. ABSTRACT Photosynthesis compartmentalizes reactions across the thylakoid membrane in vivo to upcycle CO2 into complex chemicals that are ...
Sampurna Mitra, David M. Vahey, Shannon A. Bonke, Erwin Reisner   +3 more
wiley   +2 more sources

Searching for potential acetylcholinesterase inhibitors: a combined approach of multi-step similarity search, machine learning and molecular dynamics simulations

Royal Society Open Science
Targeting acetylcholinesterase is one of the most important strategies for developing therapeutics against Alzheimer’s disease. In this work, we have employed a new approach that combines machine learning models, a multi-step similarity search of the ...
Quynh Mai Thai, Minh Quan Pham, Phuong-Thao Tran, Trung Hai Nguyen, Son Tung Ngo   +4 more
doaj   +1 more source

Polyphenol‐Inspired Materials for Agricultural Applications

Advanced Materials, EarlyView.
This review outlines the use of polyphenol‐inspired materials for sustainable agriculture, highlighting their molecular design, interfacial assembly, structure–property relationships, and prospects toward precision agriculture, climate resilience, ecosystem protection, and circular bioeconomy strategies.
Haofu Liu, Omid Mazaheri, Zhixing Lin, Tianzheng Wang, Jingqu Chen, Yuang Gu, Xia Liang, Deli Chen, Frank Caruso   +8 more
wiley   +1 more source

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors

Molecules, 2018
A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (
Keith D. Green, Marina Y. Fosso, Sylvie Garneau-Tsodikova   +2 more
doaj   +1 more source

Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing

Advanced Science, EarlyView.
Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley   +1 more source

An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet

Molecules, 2017
Acetylcholinesterase (AChE) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. AChE is an important target for treatment of various cholinergic deficiencies, including Alzheimer’s ...
Anders Allgardsson, C. David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekström   +5 more
doaj   +1 more source

Artemisia santonicum L. and Artemisia lerchiana Web. Essential Oils and Exudates as Sources of Compounds with Pesticidal Action

Plants, 2023
The application of natural products for pest control is important in modern farming. In the present study, Artemisia santonicum L. and Artemisia lerchiana Weber essential oil and exudate profiles were determined, and their potential as inhibitors of seed
Milena Nikolova, Aneta Lyubenova, Elina Yankova-Tsvetkova, Borislav Georgiev, Strahil Berkov, Ina Aneva, Antoaneta Trendafilova   +6 more
doaj   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Anticholinergic and antioxidant activities of avocado (Folium perseae) leaves – phytochemical content by LC-MS/MS analysis

International Journal of Food Properties, 2020
In the first stage of the manuscript, we aimed to examine antioxidant capacity and anticholinergic properties of avocado (Folium perseae) leaves. Avocado leaf was extracted by water (WEFP) and ethyl alcohol (EEFP) and antioxidant activity was determined ...
Leyla Polat Kose, Zeynebe Bingol, Ruya Kaya, Ahmet C. Goren, Hulya Akincioglu, Lokman Durmaz, Ekrem Koksal, Saleh H. Alwasel, İlhami Gülçin   +8 more
doaj   +1 more source

LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)

Molecules, 2021
Kınkor (Ferulago stellata) is Turkish medicinal plant species and used in folk medicine against some diseases. As far as we know, the data are not available on the biological activities and chemical composition of this medicinal plant. In this study, the
Hatice Kızıltaş, Zeynebe Bingol, Ahmet Ceyhan Gören, Leyla Polat Kose, Lokman Durmaz, Fevzi Topal, Saleh H. Alwasel, İlhami Gulcin   +7 more
doaj   +1 more source