Results 41 to 50 of about 176,476 (335)

A novel, non-neuronal acetylcholinesterase of schistosome parasites is essential for definitive host infection

Frontiers in Immunology, 2023
Schistosomes are long-lived parasitic worms that infect >200 million people globally. The intravascular life stages are known to display acetylcholinesterase (AChE) activity internally as well as, somewhat surprisingly, on external tegumental ...
Patrick J. Skelly, Akram A. Da’dara
doaj   +1 more source

Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy

Frontiers in Pharmacology, 2018
Alzheimer's disease (AD) is a main cause of dementia, accounting for up to 75% of all dementia cases. Pathophysiological processes described for AD progression involve neurons and synapses degeneration, mainly characterized by cholinergic impairment ...
Thaiane Coelho dos Santos, Thaís Mota Gomes, B. A. S. Pinto, A. L. Camara, A. M. Paes   +4 more
semanticscholar   +1 more source

Involvement of acetylcholinesterase inhibition in paralyzing effects of monocrotophos in Caenorhabditis elegans

Journal of Basic and Applied Zoology, 2018
Background Organophosphorus insecticides (OPI) are among the most commonly used class of pesticides in agricultural and domestic scenarios. Clinical presentations of acute OPI toxicity are attributable to acetylcholinesterase inhibition and ensuing ...
Apurva Kumar Ramesh Joshi, Raju Nagaraju, Padmanabhan Sharda Rajini   +2 more
doaj   +1 more source

Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors.

Bioorganic chemistry (Print), 2019
A series of substituted pyrazole compounds (1-8 and 9a, b) were synthesized and their structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole derivatives (1-8 and 9a, b) were emerged as effective inhibitors of the ...
Fikret Turkan, A. Cetin, Parham Taslimi, M. Karaman, I. Gulcin   +4 more
semanticscholar   +1 more source

Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus [PDF]

, 2008
We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR. In the present studies, mechanisms underlying the acute and chronic
Abel, Arendt, Atack, Bain, Bear, Blanquet, Bliss, Blitzer, Blitzer, Bogan, Casey, Charpantier, Cho, Dajas-Bailador, Davies, Davis, Decker, Dhavan, Dominguez del Toro, English, Faghih, Fujii, Giovannini, Gray, Hope, Huang, Huang, Hunter, Hurst, Ji, Jones, Kawakami, Kelly, Kihara, Klein, Krause, Le Novere, Levin, Li, Liston, Lu, Man, Mann, Marrero, Matsuyama, Matthies, Meriane, Opazo, O’Dell, Peavy, Picciotto, Polesskaya, Polesskaya, Radcliffe, Roberson, Rush, Salazar, Sanna, Sanna, Santos, Seguela, Sharifzadeh, Sharifzadeh, Sharma, Shaw, Shaw, Sweatt, Takada-Takatori, Tominaga-Yoshino, Wada, Wang, Wang, Welsby, Welsby, Whitehouse, Woo, Wu, Yang, Ying, Yu, Zhang, Zwart   +81 more
core   +1 more source

Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease [PDF]

, 2019
The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that dietary interventions represent helpful tools for preventing NDs.
Antonella Amato, Flavia Mulè, Simona Terzo   +2 more
core   +1 more source

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Angewandte Chemie, EarlyView.
Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin, Xing Guo, Yan Liu   +11 more
wiley   +2 more sources

A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods

Acta Medica, 2005
1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6)
Kamil Kuča, Jiří Cabal, Jiří Kassa, Daniel Jun, Martina Hrabinová   +4 more
doaj   +1 more source

The Effect of Parathion on Red Blood Cell Acetylcholinesterase in the Wistar Rat

Journal of Toxicology, 2016
Organophosphorus (OP) pesticide poisoning is a significant problem worldwide. Research into new antidotes for these acetylcholinesterase inhibitors, and even optimal doses for current therapies, is hindered by a lack of standardized animal models.
Naofumi Bunya, Keigo Sawamoto, Hanif Benoit, Steven B. Bird   +3 more
doaj   +1 more source

Serum cholinesterases are differentially regulated in normal and dystrophin-deficient mutant mice

Frontiers in Molecular Neuroscience, 2012
The cholinesterases, acetylcholinesterase and butyrylcholinesterase (pseudocholinesterase), are abundant in the nervous system and in other tissues. The role of acetylcholinesterase in terminating transmitter action in the peripheral and central nervous ...
Andrea R. Durrant, Liliya eTamayev, Lili eAnglister   +2 more
doaj   +1 more source