Results 1 to 10 of about 24,444 (255)

Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase [PDF]

Frontiers in Pharmacology, 2018
Butyrylcholinesterase (BChE), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (AChE) but with the capability to degrade a broad range of bioactive esters.
Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P. Chen   +3 more
doaj   +2 more sources

Butyrylcholinesterase-Loaded Liposomes and Polymersomes: Catalytic Parameters for Three Types of Substrates. [PDF]

Int J Mol Sci
Shaihutdinova Z, Batasheva S, Masson P, Pashirova T.   +3 more
europepmc   +3 more sources

The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke

Cerebral Circulation - Cognition and Behavior, 2021
Aim: Our study aimed to test whether plasma acetylcholinesterase and butyrylcholinesterase enzyme activity were related to the presence and intensity of delirium in acute stroke patients.
Lara Caeiro, Filipa Novais, Carlota Saldanha, Teresa Pinho e Melo, Patrícia Canhão, José M. Ferro   +5 more
doaj   +1 more source

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study

Pharmaceuticals, 2023
Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and butyrylcholinesterase inhibition profiles.
Bushra Adalat, Fazal Rahim, Wajid Rehman, Zarshad Ali, Liaqat Rasheed, Yousaf Khan, Thoraya A. Farghaly, Sulaiman Shams, Muhammad Taha, Abdul Wadood, Syed A. A. Shah, Magda H. Abdellatif   +11 more
doaj   +1 more source

5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study

Pharmaceuticals, 2022
2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthenia ...
Václav Pflégr, Šárka Štěpánková, Katarína Svrčková, Markéta Švarcová, Jarmila Vinšová, Martin Krátký   +5 more
doaj   +1 more source

Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase. [PDF]

PLoS ONE, 2013
Concerns about the safety of paralytics such as succinylcholine to facilitate endotracheal intubation limit their use in prehospital and emergency department settings.
Brian C Geyer, Katherine E Larrimore, Jacquelyn Kilbourne, Latha Kannan, Tsafrir S Mor   +4 more
doaj   +1 more source

Software for Matching Standard Activity Enzyme Biosensors for Soil Pollution Analysis

Sensors, 2021
This work is dedicated to developing enzyme biosensor software to solve problems regarding soil pollution analysis. An algorithm and specialised software have been developed which stores, analyses and visualises data using JavaScript programming language.
Valentina A. Kratasyuk, Elizaveta M. Kolosova, Oleg S. Sutormin, Viktoriya I. Lonshakova-Mukina, Matvey M. Baygin, Nadezhda V. Rimatskaya, Irina E. Sukovataya, Alexander A. Shpedt   +7 more
doaj   +1 more source

Can Marine Products Improve Alzheimer’s Disease [PDF]

Journal of Sciences, Islamic Republic of Iran, 2020
Alzheimer's disease is an irreversible chronic neurodegenerative disease which is the most common cause of dementia among older adults. According to amyloid hypothesis, cholin neurotransmitters have important roles in CNS memory function, therefore ...
Hamid-Reza Adhami, Paria Sharafi
doaj   +1 more source

Wide awake under anesthesia: Scoline apnoea update [PDF]

Serbian Journal of Anesthesia and Intensive Therapy, 2016
Butyrylcholinesterase (BChE) catalyses the hydrolysis of choline esters and thus deactivates muscle relaxants such as succinylcholine and mivacurium. The prolonged neuromuscular blockade following the use of succinylcholine, called scoline apnea, occurs ...
Marković Danica, Janković Radmilo J.
doaj   +1 more source

Design and evaluation of selective butyrylcholinesterase inhibitors based on Cinchona alkaloid scaffold. [PDF]

PLoS ONE, 2018
This paper describes the synthesis and anticholinesterase potency of Cinchona-based alkaloids; ten quaternary derivatives of cinchonines and their corresponding pseudo-enantiomeric cinchonidines. The quaternization of quinuclidine moiety of each compound
Anita Bosak, Alma Ramić, Tamara Šmidlehner, Tomica Hrenar, Ines Primožič, Zrinka Kovarik   +5 more
doaj   +1 more source