Results 1 to 10 of about 16,092 (168)

Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi-Target Inhibitors of Cholinesterases and Carbonic Anhydrases. [PDF]

J Biochem Mol Toxicol
Two novel axially substituted silicon phthalocyanines were synthesized and characterized. Compound 2a exhibited significantly enhanced inhibition of AChE, BChE, hCA I and hCA II, supported by molecular docking and SAR analysis, highlighting its potential as a multifunctional enzyme inhibitor with promising biological activity.
Ünlü S, Köksal Z, Kırboğa KK, Tuncel Elmalı F.   +3 more
europepmc   +2 more sources

Bioactive Phenolics of Lygeum spartum L.: Insights Into Antioxidant, Anticholinesterase, and Antityrosinase Activities. [PDF]

Chem Biodivers
Phenolic profile and bioactivity of Lygeum spartum L. ABSTRACT The phenolic composition of roots and leaves of Lygeum spartum L., a Mediterranean Poaceae species, was analyzed by HPLC–DAD, revealing an organ‐specific distribution of phenolic compounds, with ferulic acid identified as the predominant phenolic compound in the methanolic leaf extract (4 ...
Arabi Z, Arabi R, Çam D, Çakir C, Öztürk M, Bendif H, El-Sayyad GS, Ali MAM, Elfalleh W, Garzoli S.   +9 more
europepmc   +2 more sources

Triterpene-Based Carboxamides Act as Good Inhibitors of Butyrylcholinesterase

Molecules, 2019
A set of overall 40 carboxamides was prepared from five different natural occurring triterpenoids including oleanolic, ursolic, maslinic, betulinic, and platanic acid.
René Csuk, Wolfgang Dr Brandt, Michael Kahnt   +2 more
exaly   +3 more sources

Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study

Molecules, 2017
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission.
Xavier Brazzolotto, Ian Macdonald
exaly   +3 more sources

The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke

Cerebral Circulation - Cognition and Behavior, 2021
Aim: Our study aimed to test whether plasma acetylcholinesterase and butyrylcholinesterase enzyme activity were related to the presence and intensity of delirium in acute stroke patients.
Lara Caeiro, Filipa Novais, Carlota Saldanha, Teresa Pinho e Melo, Patrícia Canhão, José M. Ferro   +5 more
doaj   +1 more source

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study

Pharmaceuticals, 2023
Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and butyrylcholinesterase inhibition profiles.
Bushra Adalat, Fazal Rahim, Wajid Rehman, Zarshad Ali, Liaqat Rasheed, Yousaf Khan, Thoraya A. Farghaly, Sulaiman Shams, Muhammad Taha, Abdul Wadood, Syed A. A. Shah, Magda H. Abdellatif   +11 more
doaj   +1 more source

5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study

Pharmaceuticals, 2022
2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthenia ...
Václav Pflégr, Šárka Štěpánková, Katarína Svrčková, Markéta Švarcová, Jarmila Vinšová, Martin Krátký   +5 more
doaj   +1 more source

Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase. [PDF]

PLoS ONE, 2013
Concerns about the safety of paralytics such as succinylcholine to facilitate endotracheal intubation limit their use in prehospital and emergency department settings.
Brian C Geyer, Katherine E Larrimore, Jacquelyn Kilbourne, Latha Kannan, Tsafrir S Mor   +4 more
doaj   +1 more source

Software for Matching Standard Activity Enzyme Biosensors for Soil Pollution Analysis

Sensors, 2021
This work is dedicated to developing enzyme biosensor software to solve problems regarding soil pollution analysis. An algorithm and specialised software have been developed which stores, analyses and visualises data using JavaScript programming language.
Valentina A. Kratasyuk, Elizaveta M. Kolosova, Oleg S. Sutormin, Viktoriya I. Lonshakova-Mukina, Matvey M. Baygin, Nadezhda V. Rimatskaya, Irina E. Sukovataya, Alexander A. Shpedt   +7 more
doaj   +1 more source

Can Marine Products Improve Alzheimer’s Disease [PDF]

Journal of Sciences, Islamic Republic of Iran, 2020
Alzheimer's disease is an irreversible chronic neurodegenerative disease which is the most common cause of dementia among older adults. According to amyloid hypothesis, cholin neurotransmitters have important roles in CNS memory function, therefore ...
Hamid-Reza Adhami, Paria Sharafi
doaj   +1 more source