Results 1 to 10 of about 14,374 (222)
The role of acetylcholinesterase and butyrylcholinesterase activity in the development of delirium in acute stroke [PDF]
Cerebral Circulation - Cognition and Behavior, 2021 Aim: Our study aimed to test whether plasma acetylcholinesterase and butyrylcholinesterase enzyme activity were related to the presence and intensity of delirium in acute stroke patients.
Lara Caeiro +5 more
doaj +2 more sources
Deciphering Antidiabetic, Anti-Inflammatory, and Anti-Cholinergic Bioactivities of Withania somnifera (L) Dunal Root Extract: An In Vitro and In Silico Investigation. [PDF]
Chem BiodiversIn this investigation, Withania somnifera root ethanol extract displays anti‐inflammatory and antidiabetic properties. Though compounds including withasomniferolide B and sitoindoside IX have been previously identified as phytoconstituents in the plant, in silico analysis from this study revealed them as new lead compounds that could act as potential ...
Mulelu L +4 more
europepmc +2 more sources
Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase. [PDF]
PLoS ONE, 2013 Concerns about the safety of paralytics such as succinylcholine to facilitate endotracheal intubation limit their use in prehospital and emergency department settings.
Brian C Geyer +4 more
doaj +4 more sources
Pharmaceuticals, 2023 Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and butyrylcholinesterase inhibition profiles.
Bushra Adalat +11 more
doaj +1 more source
Pharmaceuticals, 2022 2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthenia ...
Václav Pflégr +5 more
doaj +1 more source
Software for Matching Standard Activity Enzyme Biosensors for Soil Pollution Analysis
Sensors, 2021 This work is dedicated to developing enzyme biosensor software to solve problems regarding soil pollution analysis. An algorithm and specialised software have been developed which stores, analyses and visualises data using JavaScript programming language.
Valentina A. Kratasyuk +7 more
doaj +1 more source
Can Marine Products Improve Alzheimer’s Disease [PDF]
Journal of Sciences, Islamic Republic of Iran, 2020 Alzheimer's disease is an irreversible chronic neurodegenerative disease which is the most common cause of dementia among older adults. According to amyloid hypothesis, cholin neurotransmitters have important roles in CNS memory function, therefore ...
Hamid-Reza Adhami, Paria Sharafi
doaj +1 more source
Wide awake under anesthesia: Scoline apnoea update [PDF]
Serbian Journal of Anesthesia and Intensive Therapy, 2016 Butyrylcholinesterase (BChE) catalyses the hydrolysis of choline esters and thus deactivates muscle relaxants such as succinylcholine and mivacurium. The prolonged neuromuscular blockade following the use of succinylcholine, called scoline apnea, occurs ...
Marković Danica, Janković Radmilo J.
doaj +1 more source
Design and evaluation of selective butyrylcholinesterase inhibitors based on Cinchona alkaloid scaffold. [PDF]
PLoS ONE, 2018 This paper describes the synthesis and anticholinesterase potency of Cinchona-based alkaloids; ten quaternary derivatives of cinchonines and their corresponding pseudo-enantiomeric cinchonidines. The quaternization of quinuclidine moiety of each compound
Anita Bosak +5 more
doaj +1 more source
Molecules, 2021 Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disease recognized as the most common form of dementia among elderly people. Due to the fact that the exact pathogenesis of AD still remains to be fully elucidated, the treatment is ...
Lucie Cahlíková +8 more
doaj +1 more source