Results 41 to 50 of about 24,444 (255)

Hupresin Retains Binding Capacity for Butyrylcholinesterase and Acetylcholinesterase after Sanitation with Sodium Hydroxide

Frontiers in Pharmacology, 2017
Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in human plasma binds to Hupresin and
Seda Onder, Seda Onder, Emilie David, Ozden Tacal, Lawrence M. Schopfer, Oksana Lockridge   +5 more
doaj   +1 more source

Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]

, 2016
Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
core   +1 more source

Anticholinesterase activities from aqueous extract of different plant parts of Erica manipuliflora

International Journal of Secondary Metabolite, 2017
Erica species are generally spread along the coasts of Turkey. There are five Erica species in these regions, namely; E. arborea, E. manipuliflora, E, bocquetii, E. sicula subsp. Libanotica and E. spiculifolia salisb.
Çiğdem Kuş, Mehmet Emin Duru, Selçuk Küçükaydın   +2 more
doaj   +1 more source

Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma

Chemico-Biological Interactions, 2016
Five mouse anti-human butyrylcholinesterase (BChE) monoclonal antibodies bind tightly to native human BChE with nanomolar dissociation constants. Pairing analysis in the Octet system identified the monoclonal antibodies that bind to overlapping and independent epitopes on human BChE.
Peng, Hong, Brimijoin, Stephen, Hrabovska, Anna, Krejci, Eric, Blake, Thomas, Johnson, Rudolph, Masson, Patrick, Lockridge, Oksana   +7 more
openaire   +5 more sources

Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning [PDF]

, 2008
Background: The usefulness of a low butyrylcholinesterase (BuChE) activity on admission for predicting severity in acute organophosphorus (OP) insecticide poisoning has long been debated. Previous studies have been confounded by the inclusion of multiple
Buckley, N. A., Eddleston, M., Eyer, P., Sheriff, M. H. Rezvi, Worek, F.   +4 more
core   +1 more source

Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering

Advanced Science, 2020
Organophosphate nerve agents rapidly inhibit cholinesterases thereby destroying the ability to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic reactivators of cholinesterase‐organophosphate complexes, but suffer from ...
Libin Zhang, Stefanie L. Baker, Hironobu Murata, Nicholas Harris, Weihang Ji, Gabriel Amitai, Krzysztof Matyjaszewski, Alan J. Russell   +7 more
doaj   +1 more source

Synthesis of Benzimidazole–Based Analogs as Anti Alzheimer’s Disease Compounds and Their Molecular Docking Studies

Molecules, 2020
We synthesized 10 analogs of benzimidazole-based thiosemicarbazide 1 (a–j) and 13 benzimidazole-based Schiff bases 2 (a–m), and characterized by various spectroscopic techniques and evaluated in vitro for acetylcholinesterase (AchE) and ...
Bushra Adalat, Fazal Rahim, Muhammad Taha, Foziah J. Alshamrani, El Hassane Anouar, Nizam Uddin, Syed Adnan Ali Shah, Zarshad Ali, Zainul Amiruddin Zakaria   +8 more
doaj   +1 more source

Butyrylcholinesterase as a prognostic marker: a review of the literature. [PDF]

, 2013
BACKGROUND: Butyrylcholinesterase (BChE) is an α-glycoprotein synthesized in the liver. Its serum level decreases in many clinical conditions such as acute and chronic liver damage, inflammation, injury and infections, and malnutrition.
Abbott, Abou-Hatab, Alcantara, Annapurna, Bozzetti, Bozzetti, Buchanan, Burritt, Calderon-Margalit, Camarero González, Caprio, Chougule, Chu, Cucuianu, Cucuianu, Cucuianu, Cucuianu, Dabke, Das, Davis, Donini, Fieber, Fuhrman, Guarnieri, Hamamoto, Hubbard, Iwasaki, Iwasaki, Jain, Jain, Jensen, Kaizu, Kean, Khalil, Kutty, Kutty, Kutty, Lampón, Lehtonen, Lurie, Lurie, Menache, Mitrache, Mitsunaga, Montagnese, Montgomery, Nomura, Novacek, Ogunkeye, Ostergaard, Ott, Paes, Pan, Pascoli, Popescu, Randell, Ravera, Robinson, Rosenman, Rustemeijer, Santarpia, Santarpia, Seiler, Shan-Zhi, Soeters, Sologub, Sportiello, Valle, Valle   +68 more
core   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie International Edition, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +1 more source

Synergistic Effect of Hesperidin, Acarbose, and Exercise Combination on Neuroinflammation and Neurochemical Alterations in Diabetic Encephalopathy Rat Model

Food Chemistry International, EarlyView.
Diabetic encephalopathy (DME) impairs neurobehavior, neurochemicals, oxidative stress, and inflammation. This study evaluated the effects of hesperidin (HSP), exercise (EX), and acarbose (ACA) alone or combined on diabetic rats. Treatments reduced AChE, BChE, ACE, arginase, ATPDase, 5′‐nucleotidase, ADA, LDH, TBARS, and ROS, while increasing IL‐10, SOD,
Idowu Sunday Oyeleye, Olajide Raymond Ojo, Taiwo Olawale Adeleke, Adeyinka Sunday Ajeigbe, Mercy Gladys Tenywa, Oboh Ganiyu   +5 more
wiley   +1 more source