Results 21 to 30 of about 14,374 (222)

Evaluation of derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases and their antioxidant activity: In vitro, in silico, and kinetics studies [PDF]

Journal of the Serbian Chemical Society, 2023
In search of potent inhibitors of cholinesterase enzymes and antioxidant agents, synthetic derivatives of dihydroquinazolin-4(1H)-one (1–38) were evaluated as potential anti-Alzheimer agents through in vitro acetylcholinesterase (AChE) and ...
Babatunde Oluwatoyin, Hameed Shehryar, Mbachu Kingsley Adibe, Saleem Faiza, Chigurupati Sridevi, Wadood Abdul, Ur Rehman Ashfaq, Venugopal Vijayan, Khan Khalid Mohammed, Taha Muhammad, Ekundayo Olusegun, Khan Maria Aqeel   +11 more
doaj   +1 more source

Serum cholinesterases are differentially regulated in normal and dystrophin-deficient mutant mice

Frontiers in Molecular Neuroscience, 2012
The cholinesterases, acetylcholinesterase and butyrylcholinesterase (pseudocholinesterase), are abundant in the nervous system and in other tissues. The role of acetylcholinesterase in terminating transmitter action in the peripheral and central nervous ...
Andrea R. Durrant, Liliya eTamayev, Lili eAnglister   +2 more
doaj   +1 more source

Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients [PDF]

, 2017
Natsalil Pongthanaracht,1 Somchai Yanarojana,1 Darawan Pinthong,1 Supeenun Unchern,1 Amnuay Thithapandha,1 Prasert Assantachai,2 Porntip Supavilai11Department of Pharmacology, Faculty of Science, 2Department of Preventive and Social Medicine, Faculty of ...
Somchai Yanarojana, Pinthong D, Pongthanaracht N, Unchern S, Thithapandha A, Supeenun Unchern, Natsalil Pongthanaracht, Porntip Supavilai, Yanarojana S, Amnuay Thithapandha, Supavilai P, Assantachai P, Prasert Assantachai, Darawan Pinthong   +13 more
core   +2 more sources

Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase [PDF]

International Journal of Molecular Sciences, 2013
Caffeine is an alkaloid with a stimulant effect in the body. It can interfere in transmissions based on acetylcholine, epinephrine, norepinephrine, serotonin, dopamine and glutamate. Clinical studies indicate that it can be involved in the slowing of Alzheimer disease pathology and some other effects. The effects are not well understood. In the present
Miroslav Pohanka, Petr Dobes
openaire   +2 more sources

Polymeric Membrane Ion-Selective Electrode for Butyrylcholinesterase Based on Controlled Release of Substrate [PDF]

, 2009
A butyrylcholine selective polymeric membrane electrode using o-beta-cyclodextrin as ionophore is described as a reagent controlled-release system for reagentless detection of butyrylcholinesterase.
Jiawang Ding, Ding, JW, Ding, Jiawang, Wei Qin, Qin, W, Qin, Wei   +5 more
core   +1 more source

Electrochemical MIP Sensor for Butyrylcholinesterase [PDF]

Polymers, 2019
Molecularly imprinted polymers (MIPs) mimic the binding sites of antibodies by substituting the amino acid-scaffold of proteins by synthetic polymers. In this work, the first MIP for the recognition of the diagnostically relevant enzyme butyrylcholinesterase (BuChE) is presented.
Ozcelikay, Goksu, Kurbanoglu, Sevinc, Zhang, Xiaorong, Söz, Çağla Kosak, Wollenberger, Ulla, Ozkan, Sibel A., Yarman, Aysu, Scheller, Frieder W.   +7 more
openaire   +5 more sources

Antioxidant, Antidiabetic, Anticholinergic, and Antiglaucoma Effects of Magnofluorine

Molecules, 2022
Magnofluorine, a secondary metabolite commonly found in various plants, has pharmacological potential; however, its antioxidant and enzyme inhibition effects have not been investigated.
Lokman Durmaz, Hatice Kiziltas, Leyla Guven, Hasan Karagecili, Saleh Alwasel, İlhami Gulcin   +5 more
doaj   +1 more source

Decreased activity of butyrylcholinesterase in blood plasma of patients with chronic obstructive pulmonary disease [PDF]

, 2016
Introduction : Butyrylcholinesterase (BChE) is involved in the metabolism of endogenous lipids and xenobiotics, such as esters of carboxylic or phosphoric acids.
Aneta Koceva-Chyla, Maria Koter-Michalak, Piotr Nizinkowski, Tadeusz Pietras, Bozena Bukowska, Paulina Sicinska, Aneta Pajak, Paweł Gorski   +7 more
core   +1 more source

Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer’s Disease [PDF]

Butyrylcholinesterase (BChE) is a promising biomarker and effective therapeutic target for Alzheimer’s disease (AD). Herein, we designed a BChE-activated near-infrared (NIR) probe, DTNP, which could be activated by BChE and inhibit its enzymatic activity.
Wei Li (7081), Huajing Yang (9440069), Lei Wang (6656), Haopeng Sun (1464940), Tengfei Zhen (18270619), Yao Chen (149006), Suyu Wang (4729044), Feng Feng (93102), Tianyu Sun (2795815)   +8 more
core   +3 more sources

Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity

Molecules, 2022
Transformations of 1-methoxymethylethynyl substituted isoquinolines triggered by terminal alkynes in alcohols were studied and new 3-benzazecine-containing compounds synthesized, such as 6-methoxymethyl-3-benzazecines incorporating an endocyclic C6–C8 ...
Alexander A. Titov, Rosa Purgatorio, Arina Y. Obydennik, Anna V. Listratova, Tatiana N. Borisova, Modesto de Candia, Marco Catto, Cosimo D. Altomare, Alexey V. Varlamov, Leonid G. Voskressensky   +9 more
doaj   +1 more source