Results 21 to 30 of about 14,314 (224)
Pharmaceuticals, 2023 Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and butyrylcholinesterase inhibition profiles.
Bushra Adalat +11 more
doaj +1 more source
Pharmaceuticals, 2022 2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthenia ...
Václav Pflégr +5 more
doaj +1 more source
Software for Matching Standard Activity Enzyme Biosensors for Soil Pollution Analysis
Sensors, 2021 This work is dedicated to developing enzyme biosensor software to solve problems regarding soil pollution analysis. An algorithm and specialised software have been developed which stores, analyses and visualises data using JavaScript programming language.
Valentina A. Kratasyuk +7 more
doaj +1 more source
Can Marine Products Improve Alzheimer’s Disease [PDF]
Journal of Sciences, Islamic Republic of Iran, 2020 Alzheimer's disease is an irreversible chronic neurodegenerative disease which is the most common cause of dementia among older adults. According to amyloid hypothesis, cholin neurotransmitters have important roles in CNS memory function, therefore ...
Hamid-Reza Adhami, Paria Sharafi
doaj +1 more source
Wide awake under anesthesia: Scoline apnoea update [PDF]
Serbian Journal of Anesthesia and Intensive Therapy, 2016 Butyrylcholinesterase (BChE) catalyses the hydrolysis of choline esters and thus deactivates muscle relaxants such as succinylcholine and mivacurium. The prolonged neuromuscular blockade following the use of succinylcholine, called scoline apnea, occurs ...
Marković Danica, Janković Radmilo J.
doaj +1 more source
Design and evaluation of selective butyrylcholinesterase inhibitors based on Cinchona alkaloid scaffold. [PDF]
PLoS ONE, 2018 This paper describes the synthesis and anticholinesterase potency of Cinchona-based alkaloids; ten quaternary derivatives of cinchonines and their corresponding pseudo-enantiomeric cinchonidines. The quaternization of quinuclidine moiety of each compound
Anita Bosak +5 more
doaj +1 more source
Molecules, 2021 Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disease recognized as the most common form of dementia among elderly people. Due to the fact that the exact pathogenesis of AD still remains to be fully elucidated, the treatment is ...
Lucie Cahlíková +8 more
doaj +1 more source
Comparison of butyrylcholinesterase and acetylcholinesterase [PDF]
Biochemical Journal, 1989 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are compared, the first focus being on the high homologies of the molecular forms, and the homologies in protein sequences. Cholinesterases are the prototype of a new family of related serine hydrolases. Secondly, the distribution and regulation of AChE and BChE is reviewed.
Chatonnet, Arnaud, Lockridge, O.
openaire +3 more sources
Учёные записки Казанского университета: Серия Естественные науки, 2021 Cholinesterase inhibitors have been the subject of many studies aimed at developing an effective treatment for various cognitive disorders. Therefore, studying cholinesterases and elucidating the mechanism of their interaction with ligands provide a ...
A.R. Mukhametgalieva +3 more
doaj +1 more source
Serum cholinesterases are differentially regulated in normal and dystrophin-deficient mutant mice
Frontiers in Molecular Neuroscience, 2012 The cholinesterases, acetylcholinesterase and butyrylcholinesterase (pseudocholinesterase), are abundant in the nervous system and in other tissues. The role of acetylcholinesterase in terminating transmitter action in the peripheral and central nervous ...
Andrea R. Durrant +2 more
doaj +1 more source