Butyrylcholinesterase deficiency identified after succinylcholine administration. Case report [PDF]
Iatreia, 2018 The main function of the enzyme butyrylcholinesterase is to hydrolyze exogenous esters such as those present in the neuromuscular blocking agent succinylcholine, which is frequently used in short surgical procedures.
Manzano Rincón, Yolima +3 more
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Cord Blood Butyrylcholinesterase Activities in Normal Pregnant and Preeclamptic Women [PDF]
Avicenna Journal of Medical Biochemistry, 2016 Background Human placenta, a non-neural tissue, contains cholinergic system and high-affinity muscarinic receptors. The role of cholinesterases (CE) in trophoblast function and pregnancy is not clear. Objectives
Kharb +5 more
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The interaction of amiloride with acetylcholinesterase and butyrylcholinesterase [PDF]
FEBS Letters, 1990 The diuretic drug amiloride was found to be a powerful inhibitor of the reaction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with their specific choline ester substrates. The inhibition constant is in the micromolar range. On the other hand, when added to a mixture of cholinesterase (AChE and BChE) and neutral substrates, amiloride,
Zemach, Lucie +2 more
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Influence of obstructive sleep apnea on serum butyrylcholinesterase activity and ischemia-modified albumin levels [PDF]
Clinics, 2013 OBJECTIVE: To investigate the effect of obstructive sleep apnea and continuous positive airway pressure treatment on serum butyrylcholinesterase activity and ischemia-modified albumin levels.
Liu-Xue Yang +3 more
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Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development [PDF]
Molecules, 2017 Human butyrylcholinesterase is a performant stoichiometric bioscavenger of organophosphorous nerve agents. It is either isolated from outdated plasma or functionally expressed in eukaryotic systems.
Xavier Brazzolotto +4 more
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Serum butyrylcholinesterase in type 2 diabetes mellitus: a biochemical and bioinformatics approach [PDF]
Lipids in Health and Disease, 2005 Background Butyrylcholinesterase is an enzyme that may serve as a marker of metabolic syndrome. We (a) measured its level in persons with diabetes mellitus, (b) constructed a family tree of the enzyme using nucleotide sequences downloaded from NCBI ...
Sreelatha S +6 more
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The Selectivity of Butyrylcholinesterase Inhibitors Revisited
MoleculesAcetylcholinesterase (AChE) inhibitors are the primary target for single-molecule anti-Alzheimer’s disease (AD) therapeutics. Though AChE has historically been the focus of investigation for small-molecule inhibitors, interest in another cholinergic ...
Michael D. Gambardella +2 more
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Pseudo-irreversible butyrylcholinesterase inhibitors: structure–activity relationships, and kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate warhead [PDF]
, 2022 Alongside reversible butyrylcholinesterase inhibitors, a plethora of covalent butyrylcholinesterase inhibitors have been reported in the literature, typically pseudo-irreversible carbamates. For these latter, however, most cases lack full confirmation of
Anže , Meden +10 more
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Comparison of butyrylcholinesterase and acetylcholinesterase [PDF]
Biochemical Journal, 1989 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are compared, the first focus being on the high homologies of the molecular forms, and the homologies in protein sequences. Cholinesterases are the prototype of a new family of related serine hydrolases. Secondly, the distribution and regulation of AChE and BChE is reviewed.
Chatonnet, Arnaud, Lockridge, O.
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Учёные записки Казанского университета: Серия Естественные науки, 2021 Cholinesterase inhibitors have been the subject of many studies aimed at developing an effective treatment for various cognitive disorders. Therefore, studying cholinesterases and elucidating the mechanism of their interaction with ligands provide a ...
A.R. Mukhametgalieva +3 more
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