Results 31 to 40 of about 14,314 (224)

Evaluation of derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases and their antioxidant activity: In vitro, in silico, and kinetics studies [PDF]

Journal of the Serbian Chemical Society, 2023
In search of potent inhibitors of cholinesterase enzymes and antioxidant agents, synthetic derivatives of dihydroquinazolin-4(1H)-one (1–38) were evaluated as potential anti-Alzheimer agents through in vitro acetylcholinesterase (AChE) and ...
Babatunde Oluwatoyin, Hameed Shehryar, Mbachu Kingsley Adibe, Saleem Faiza, Chigurupati Sridevi, Wadood Abdul, Ur Rehman Ashfaq, Venugopal Vijayan, Khan Khalid Mohammed, Taha Muhammad, Ekundayo Olusegun, Khan Maria Aqeel   +11 more
doaj   +1 more source

Pseudo-irreversible butyrylcholinesterase inhibitors: structure–activity relationships, and kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate warhead

, 2022
Alongside reversible butyrylcholinesterase inhibitors, a plethora of covalent butyrylcholinesterase inhibitors have been reported in the literature, typically pseudo-irreversible carbamates. For these latter, however, most cases lack full confirmation of
Anže , Meden, Anja, Pišlar, Stane, Pajk, Damijan, Knez, Xavier, Brazzolotto, Florian, Nachon, Milica, Denic, Andrej , Perdih, Fabrice, Modeste, Maša, Zorman, Stanislav, Gobec   +10 more
core   +1 more source

Electrochemical MIP Sensor for Butyrylcholinesterase [PDF]

Polymers, 2019
Molecularly imprinted polymers (MIPs) mimic the binding sites of antibodies by substituting the amino acid-scaffold of proteins by synthetic polymers. In this work, the first MIP for the recognition of the diagnostically relevant enzyme butyrylcholinesterase (BuChE) is presented.
Ozcelikay, Goksu, Kurbanoglu, Sevinc, Zhang, Xiaorong, Söz, Çağla Kosak, Wollenberger, Ulla, Ozkan, Sibel A., Yarman, Aysu, Scheller, Frieder W.   +7 more
openaire   +5 more sources

Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase [PDF]

International Journal of Molecular Sciences, 2013
Caffeine is an alkaloid with a stimulant effect in the body. It can interfere in transmissions based on acetylcholine, epinephrine, norepinephrine, serotonin, dopamine and glutamate. Clinical studies indicate that it can be involved in the slowing of Alzheimer disease pathology and some other effects. The effects are not well understood. In the present
Miroslav Pohanka, Petr Dobes
openaire   +2 more sources

Antioxidant, Antidiabetic, Anticholinergic, and Antiglaucoma Effects of Magnofluorine

Molecules, 2022
Magnofluorine, a secondary metabolite commonly found in various plants, has pharmacological potential; however, its antioxidant and enzyme inhibition effects have not been investigated.
Lokman Durmaz, Hatice Kiziltas, Leyla Guven, Hasan Karagecili, Saleh Alwasel, İlhami Gulcin   +5 more
doaj   +1 more source

Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity

Molecules, 2022
Transformations of 1-methoxymethylethynyl substituted isoquinolines triggered by terminal alkynes in alcohols were studied and new 3-benzazecine-containing compounds synthesized, such as 6-methoxymethyl-3-benzazecines incorporating an endocyclic C6–C8 ...
Alexander A. Titov, Rosa Purgatorio, Arina Y. Obydennik, Anna V. Listratova, Tatiana N. Borisova, Modesto de Candia, Marco Catto, Cosimo D. Altomare, Alexey V. Varlamov, Leonid G. Voskressensky   +9 more
doaj   +1 more source

Critically Ill COVID-19 Patients Show Reduced Point of Care-Measured Butyrylcholinesterase Activity—A Prospective, Monocentric Observational Study

Diagnostics, 2022
A biomarker for risk stratification and disease severity assessment in SARS-CoV-2 infections has not yet been established. Point of care testing (POCT) of butyrylcholinesterase (BChE) enables early detection of systemic inflammatory responses and ...
Florian Espeter, David Künne, Lena Garczarek, Henning Kuhlmann, Annabell Skarabis, Aleksandar R. Zivkovic, Thorsten Brenner, Karsten Schmidt   +7 more
doaj   +1 more source

Enhancement of Fear Extinction Memory and Resistance to Age-Related Cognitive Decline in Butyrylcholinesterase Knockout Mice and (R)-Bambuterol Treated Mice

Biology, 2021
Butyrylcholinesterase (BChE) is detected in plaques preferentially in Alzheimer’s disease (AD) and may be associated with stress disorders. However, the physiological function of BChE in the central nervous system remains to be further investigated. BChE
Weiwei Liu, Yan Cao, Yue Lin, Keai Sinn Tan, Haishan Zhao, Haihua Guo, Wen Tan   +6 more
doaj   +1 more source

4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B

Molecules, 2021
The multi-target-directed ligands (MTDLs) strategy is encouraged for the development of novel modulators targeting multiple pathways in the neurodegenerative cascade typical for Alzheimer’s disease (AD). Based on the structure of an in-house irreversible
Tjaša Mazej, Damijan Knez, Anže Meden, Stanislav Gobec, Matej Sova   +4 more
doaj   +1 more source

Butyrylcholinesterase and the cholinergic system

Neuroscience, 2013
The cholinergic system plays important roles in neurotransmission in both the peripheral and central nervous systems. The cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and its action terminated by acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).
Reid, G.A., Chilukuri, N., Darvesh, S.
openaire   +2 more sources