Results 31 to 40 of about 16,092 (168)

4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B

Molecules, 2021
The multi-target-directed ligands (MTDLs) strategy is encouraged for the development of novel modulators targeting multiple pathways in the neurodegenerative cascade typical for Alzheimer’s disease (AD). Based on the structure of an in-house irreversible
Tjaša Mazej, Damijan Knez, Anže Meden, Stanislav Gobec, Matej Sova   +4 more
doaj   +1 more source

Hupresin Retains Binding Capacity for Butyrylcholinesterase and Acetylcholinesterase after Sanitation with Sodium Hydroxide

Frontiers in Pharmacology, 2017
Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in human plasma binds to Hupresin and
Seda Onder, Seda Onder, Emilie David, Ozden Tacal, Lawrence M. Schopfer, Oksana Lockridge   +5 more
doaj   +1 more source

Anticholinesterase activities from aqueous extract of different plant parts of Erica manipuliflora

International Journal of Secondary Metabolite, 2017
Erica species are generally spread along the coasts of Turkey. There are five Erica species in these regions, namely; E. arborea, E. manipuliflora, E, bocquetii, E. sicula subsp. Libanotica and E. spiculifolia salisb.
Çiğdem Kuş, Mehmet Emin Duru, Selçuk Küçükaydın   +2 more
doaj   +1 more source

Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering

Advanced Science, 2020
Organophosphate nerve agents rapidly inhibit cholinesterases thereby destroying the ability to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic reactivators of cholinesterase‐organophosphate complexes, but suffer from ...
Libin Zhang, Stefanie L. Baker, Hironobu Murata, Nicholas Harris, Weihang Ji, Gabriel Amitai, Krzysztof Matyjaszewski, Alan J. Russell   +7 more
doaj   +1 more source

Synthesis of Benzimidazole–Based Analogs as Anti Alzheimer’s Disease Compounds and Their Molecular Docking Studies

Molecules, 2020
We synthesized 10 analogs of benzimidazole-based thiosemicarbazide 1 (a–j) and 13 benzimidazole-based Schiff bases 2 (a–m), and characterized by various spectroscopic techniques and evaluated in vitro for acetylcholinesterase (AchE) and ...
Bushra Adalat, Fazal Rahim, Muhammad Taha, Foziah J. Alshamrani, El Hassane Anouar, Nizam Uddin, Syed Adnan Ali Shah, Zarshad Ali, Zainul Amiruddin Zakaria   +8 more
doaj   +1 more source

Polymeric Membrane Ion-Selective Electrode for Butyrylcholinesterase Based on Controlled Release of Substrate

, 2009
A butyrylcholine selective polymeric membrane electrode using o-beta-cyclodextrin as ionophore is described as a reagent controlled-release system for reagentless detection of butyrylcholinesterase.
Jiawang Ding, Ding, JW, Ding, Jiawang, Wei Qin, Qin, W, Qin, Wei   +5 more
core   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Decreased activity of butyrylcholinesterase in blood plasma of patients with chronic obstructive pulmonary disease

, 2016
Introduction : Butyrylcholinesterase (BChE) is involved in the metabolism of endogenous lipids and xenobiotics, such as esters of carboxylic or phosphoric acids.
Aneta Koceva-Chyla, Maria Koter-Michalak, Piotr Nizinkowski, Tadeusz Pietras, Bozena Bukowska, Paulina Sicinska, Aneta Pajak, Paweł Gorski   +7 more
core   +1 more source

Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer’s Disease

Butyrylcholinesterase (BChE) is a promising biomarker and effective therapeutic target for Alzheimer’s disease (AD). Herein, we designed a BChE-activated near-infrared (NIR) probe, DTNP, which could be activated by BChE and inhibit its enzymatic activity.
Wei Li (7081), Huajing Yang (9440069), Lei Wang (6656), Haopeng Sun (1464940), Tengfei Zhen (18270619), Yao Chen (149006), Suyu Wang (4729044), Feng Feng (93102), Tianyu Sun (2795815)   +8 more
core   +2 more sources

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source