Results 31 to 40 of about 14,374 (222)
Diagnostics, 2022 A biomarker for risk stratification and disease severity assessment in SARS-CoV-2 infections has not yet been established. Point of care testing (POCT) of butyrylcholinesterase (BChE) enables early detection of systemic inflammatory responses and ...
Florian Espeter +7 more
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Biology, 2021 Butyrylcholinesterase (BChE) is detected in plaques preferentially in Alzheimer’s disease (AD) and may be associated with stress disorders. However, the physiological function of BChE in the central nervous system remains to be further investigated. BChE
Weiwei Liu +6 more
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Butyrylcholinesterase: impact on symptoms and progression of cognitive impairment [PDF]
, 2005 The most successful approach for treating people with Alzheimer's disease to date has been by improving cholinergic transmission using cholinesterase inhibitors.
Elaine K Perry +5 more
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Molecules, 2021 The multi-target-directed ligands (MTDLs) strategy is encouraged for the development of novel modulators targeting multiple pathways in the neurodegenerative cascade typical for Alzheimer’s disease (AD). Based on the structure of an in-house irreversible
Tjaša Mazej +4 more
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Butyrylcholinesterase and the cholinergic system
Neuroscience, 2013 The cholinergic system plays important roles in neurotransmission in both the peripheral and central nervous systems. The cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and its action terminated by acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).
Reid, G.A., Chilukuri, N., Darvesh, S.
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Butyrylcholinesterase–Protein Interactions in Human Serum [PDF]
International Journal of Molecular Sciences, 2021 Measuring various biochemical and cellular components in the blood is a routine procedure in clinical practice. Human serum contains hundreds of diverse proteins secreted from all cells and tissues in healthy and diseased states. Moreover, some serum proteins have specific strong interactions with other blood components, but most interactions are ...
Jacek Jasiecki +6 more
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Butyrylcholinesterase and Cognitive Function
International Psychogeriatrics, 2001 Butyrylcholinesterase (BuChE) is expressed in brain structures involved in cognition, but the effect of selective BuChE inhibitors on human cognitive function is unknown. We report a patient whose cognitive function deteriorated following a reduction and improved following reinstitution of ethopropazine, a selective BuChE inhibitor.
S, Darvesh, C, MacKnight, K, Rockwood
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Frontiers in Pharmacology, 2017 Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in human plasma binds to Hupresin and
Seda Onder +5 more
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Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase [PDF]
Chemistry – A European Journal, 2019 AbstractOrganophosphorus (OP) nerve agents and pesticides present significant threats to civilian and military populations. OP compounds include the nefarious G and V chemical nerve agents, but more commonly, civilians are exposed to less toxic OP pesticides, resulting in the same negative toxicological effects and thousands of deaths on an annual ...
Andrew J. Franjesevic +5 more
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Carbamates with Differential Mechanism of Inhibition Toward Acetylcholinesterase and Butyrylcholinesterase [PDF]
, 2016 Most carbamates are pseudoirreversible inhibitors of cholinesterases. Phenothiazine carbamates exhibit this inhibition of acetylcholinesterase but produce reversible inhibition of butyrylcholinesterase, suggesting that they do not form a covalent bond ...
Earl Martin (2222803) +7 more
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