Results 31 to 40 of about 24,444 (255)

Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity

open access: yesMolecules, 2022
Transformations of 1-methoxymethylethynyl substituted isoquinolines triggered by terminal alkynes in alcohols were studied and new 3-benzazecine-containing compounds synthesized, such as 6-methoxymethyl-3-benzazecines incorporating an endocyclic C6–C8 ...
Alexander A. Titov   +9 more
doaj   +1 more source

Two-step separation of nostotrebin 6 from cultivated soil cyanobacterium (Nostoc sp.) by high performance countercurrent chromatography [PDF]

open access: yes, 2014
High performance countercurrent chromatography (HPCCC) was successfully applied for the separation of nostotrebin 6 from cultivated soil cyanobacteria in a two-step operation.
Berthod   +13 more
core   +2 more sources

Comparison of butyrylcholinesterase and acetylcholinesterase [PDF]

open access: yesBiochemical Journal, 1989
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are compared, the first focus being on the high homologies of the molecular forms, and the homologies in protein sequences. Cholinesterases are the prototype of a new family of related serine hydrolases. Secondly, the distribution and regulation of AChE and BChE is reviewed.
Chatonnet, Arnaud, Lockridge, O.
openaire   +3 more sources

Critically Ill COVID-19 Patients Show Reduced Point of Care-Measured Butyrylcholinesterase Activity—A Prospective, Monocentric Observational Study

open access: yesDiagnostics, 2022
A biomarker for risk stratification and disease severity assessment in SARS-CoV-2 infections has not yet been established. Point of care testing (POCT) of butyrylcholinesterase (BChE) enables early detection of systemic inflammatory responses and ...
Florian Espeter   +7 more
doaj   +1 more source

Butyrylcholinesterase and Cognitive Function

open access: yesInternational Psychogeriatrics, 2001
Butyrylcholinesterase (BuChE) is expressed in brain structures involved in cognition, but the effect of selective BuChE inhibitors on human cognitive function is unknown. We report a patient whose cognitive function deteriorated following a reduction and improved following reinstitution of ethopropazine, a selective BuChE inhibitor.
S, Darvesh, C, MacKnight, K, Rockwood
openaire   +2 more sources

Enhancement of Fear Extinction Memory and Resistance to Age-Related Cognitive Decline in Butyrylcholinesterase Knockout Mice and (R)-Bambuterol Treated Mice

open access: yesBiology, 2021
Butyrylcholinesterase (BChE) is detected in plaques preferentially in Alzheimer’s disease (AD) and may be associated with stress disorders. However, the physiological function of BChE in the central nervous system remains to be further investigated. BChE
Weiwei Liu   +6 more
doaj   +1 more source

IGFBP-5 as a biomarker of de-differentiation in hepatocytes [PDF]

open access: yes, 2011
Describes IGFBP-5 as a biomarker of de-differentiation in hepatocytes presented at the 47th Congress of the European-Societies-of ...
Flint, David   +3 more
core   +1 more source

Butyrylcholinesterase Genetic Variants: Association with Cocaine Dependence and Related Phenotypes [PDF]

open access: yes, 2013
Objective: the search for genetic vulnerability factors in cocaine dependence has focused on the role that neuroplasticity plays in addiction. However, like many other drugs, the ability of an individual to metabolize cocaine can also influence ...
Guindalini, Camila   +6 more
core   +7 more sources

4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B

open access: yesMolecules, 2021
The multi-target-directed ligands (MTDLs) strategy is encouraged for the development of novel modulators targeting multiple pathways in the neurodegenerative cascade typical for Alzheimer’s disease (AD). Based on the structure of an in-house irreversible
Tjaša Mazej   +4 more
doaj   +1 more source

Pretraživanje tradicionalnih europskih ljekovitih biljaka na inhibiciju acetilkolinesteraze i butirilkolinesteraze [PDF]

open access: yes, 2010
Acetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of Alzheimer’s disease (AD) to enhance central cholinergic transmission. On the other hand, butyrylcholinesterase (BuChE) inhibitors were reported to produce significant
A. Adsersen   +16 more
core   +3 more sources

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