Results 51 to 60 of about 14,374 (222)
Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy [PDF]
, 2017 We report herein the structure-based design and application of a fluorogenic butyrylcholinesterase probe that could discriminate butyrylcholinesterase from acetylcholinesterase.
Wen-Chao Yang +6 more
core +1 more source
Biomolecules, 2020 Thirteen known (1–12 and 16) and three previously undescribed Amaryllidaceae alkaloids of belladine structural type, named carltonine A-C (13–15), were isolated from bulbs of Narcissus pseudonarcissus cv.
Abdullah Al Mamun +10 more
doaj +1 more source
Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways
British Journal of Pharmacology, EarlyView.Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck +1 more
wiley +1 more source
PLoS ONE, 2011 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are thought to be the result of a gene duplication event early in vertebrate evolution. To learn more about the evolution of these enzymes, we expressed in vitro, characterized, and modeled a recombinant cholinesterase (ChE) from a teleost, the medaka Oryzias latipes.
Pezzementi, Leo +2 more
openaire +6 more sources
Targeting acetylcholinesterase and butyrylcholinesterase in dementia [PDF]
The International Journal of Neuropsychopharmacology, 2005 The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain acetylcholinesterase (AChE) has been the major therapeutic target of ChE-I treatment strategies for Alzheimer's disease (AD).
Roger M, Lane +2 more
openaire +2 more sources
Relationship between serum butyrylcholinesterase activity, hypertriglyceridaemia and insulin sensitivity in diabetes mellitus [PDF]
, 1993 The activity of serum butyrylcholinesterase ('pseudocholinesterase', EC3.1.1.8) was investigated in 56 patients with type 1 diabetes mellitus, 51 patients with type 2 diabetes mellitus and 101 healthy control subjects.
Olukoga, A. O. +8 more
core +1 more source
Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer’s Disease
Molecules, 2018 Alzheimer’s disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the weakening of the cholinergic
Weiam Hussein +6 more
doaj +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.An “on‐water” scalable Pd‐catalyzed heteroannulation delivers benzofurans and furopyridines at ultralow catalyst loadings (down to 0.005 mol%), providing products essentially free of palladium residues. In addition to a broad substrate scope (aryl, alkenyl, and alkyl alkynes with o‐iodophenols or 2‐iodo‐3‐hydroxypyridines), this protocol enables a new ...
Iratxe Astarloa +3 more
wiley +1 more source
Molecular forms of butyrylcholinesterase and obesity [PDF]
Genetics and Molecular Biology, 2010 This study compared obese (N = 134) and unobese (N = 92) male blood donors, regarding the relative intensity (RI) and activity of different molecular forms (G1, G2, G4 and G1-ALB) of butyrylcholinesterase (BChE, EC 3.1.1.8) found in plasma, thereby searching for an association between these variables with obesity and SNPs of exons 1 and 4 of the BCHE ...
Boberg, Dellyana R. +3 more
openaire +5 more sources
Correlation of butyrylcholinesterase activity within young patients and remaining age strata. [PDF]
, 2015 Continuous data are presented as median (interquartile range) and their association with butyrylcholinesterase was assessed using Spearman–Rho correlation coefficient.
Stefan Forster (5663299) +8 more
core +1 more source