Results 51 to 60 of about 14,314 (224)

Polymeric Membrane Ion-Selective Electrode for Butyrylcholinesterase Based on Controlled Release of Substrate

, 2009
A butyrylcholine selective polymeric membrane electrode using o-beta-cyclodextrin as ionophore is described as a reagent controlled-release system for reagentless detection of butyrylcholinesterase.
Jiawang Ding, Ding, JW, Ding, Jiawang, Wei Qin, Qin, W, Qin, Wei   +5 more
core   +1 more source

Decreased activity of butyrylcholinesterase in blood plasma of patients with chronic obstructive pulmonary disease

, 2016
Introduction : Butyrylcholinesterase (BChE) is involved in the metabolism of endogenous lipids and xenobiotics, such as esters of carboxylic or phosphoric acids.
Aneta Koceva-Chyla, Maria Koter-Michalak, Piotr Nizinkowski, Tadeusz Pietras, Bozena Bukowska, Paulina Sicinska, Aneta Pajak, Paweł Gorski   +7 more
core   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie International Edition, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +1 more source

Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer’s Disease

Butyrylcholinesterase (BChE) is a promising biomarker and effective therapeutic target for Alzheimer’s disease (AD). Herein, we designed a BChE-activated near-infrared (NIR) probe, DTNP, which could be activated by BChE and inhibit its enzymatic activity.
Wei Li (7081), Huajing Yang (9440069), Lei Wang (6656), Haopeng Sun (1464940), Tengfei Zhen (18270619), Yao Chen (149006), Suyu Wang (4729044), Feng Feng (93102), Tianyu Sun (2795815)   +8 more
core   +2 more sources

Electrochemical Biosensors based on Acetylcholinesterase and Butyrylcholinesterase. A Review

International Journal of Electrochemical Science, 2016
Two cholinesterases are known: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The both enzymes are presented in the body under physiological conditions and the both enzymes have broad use in pharmacology, toxicology and analyses.
Miroslav Pohanka
doaj   +1 more source

Pursuing the Complexity of Alzheimer’s Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists

Biomolecules, 2020
Alzheimer’s disease (AD) is a complex disorder with unknown etiology. Currently, only symptomatic therapy of AD is available, comprising cholinesterase inhibitors and N-methyl-d-aspartate (NMDA) receptor antagonists. Drugs targeting only one pathological
Jan Konecny, Anna Misiachna, Martina Hrabinova, Lenka Pulkrabkova, Marketa Benkova, Lukas Prchal, Tomas Kucera, Tereza Kobrlova, Vladimir Finger, Marharyta Kolcheva, Stepan Kortus, Daniel Jun, Marian Valko, Martin Horak, Ondrej Soukup, Jan Korabecny   +15 more
doaj   +1 more source

Recent Progress on Enzyme Immobilization: Materials, Strategies, and Applications

Food Bioengineering, EarlyView.
Enzyme immobilization technology has undergone substantial evolution driven by advances in materials science. This review systematically examines the recent advances in enzyme immobilization since 2024, with a focused analysis of five major categories of enzyme carriers including covalent organic framework, metal‐organic frameworks, polymers, carbon ...
Shuran Wang, Ruoke Li, Yixuan Xie, Hanya Zhang, Xiaoyu Huang, Siwei Chen, Weixin Xu, Yueling Liu   +7 more
wiley   +1 more source

Synergistic Effect of Hesperidin, Acarbose, and Exercise Combination on Neuroinflammation and Neurochemical Alterations in Diabetic Encephalopathy Rat Model

Food Chemistry International, EarlyView.
Diabetic encephalopathy (DME) impairs neurobehavior, neurochemicals, oxidative stress, and inflammation. This study evaluated the effects of hesperidin (HSP), exercise (EX), and acarbose (ACA) alone or combined on diabetic rats. Treatments reduced AChE, BChE, ACE, arginase, ATPDase, 5′‐nucleotidase, ADA, LDH, TBARS, and ROS, while increasing IL‐10, SOD,
Idowu Sunday Oyeleye, Olajide Raymond Ojo, Taiwo Olawale Adeleke, Adeyinka Sunday Ajeigbe, Mercy Gladys Tenywa, Oboh Ganiyu   +5 more
wiley   +1 more source

Evolution of Acetylcholinesterase and Butyrylcholinesterase in the Vertebrates: An Atypical Butyrylcholinesterase from the Medaka Oryzias latipes

PLoS ONE, 2011
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are thought to be the result of a gene duplication event early in vertebrate evolution. To learn more about the evolution of these enzymes, we expressed in vitro, characterized, and modeled a recombinant cholinesterase (ChE) from a teleost, the medaka Oryzias latipes.
Pezzementi, Leo, Nachon, Florian, Chatonnet, Arnaud   +2 more
openaire   +6 more sources

Targeting acetylcholinesterase and butyrylcholinesterase in dementia [PDF]

The International Journal of Neuropsychopharmacology, 2005
The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain acetylcholinesterase (AChE) has been the major therapeutic target of ChE-I treatment strategies for Alzheimer's disease (AD).
Roger M, Lane, Steven G, Potkin, Albert, Enz   +2 more
openaire   +2 more sources