Results 71 to 80 of about 16,092 (168)

Design, Synthesis, and Biological Evaluation of Benzimidazol‐2‐One Hybrids as Potential Anti‐Alzheimer's Disease Agents

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder for which single‐target therapies often provide insufficient benefit, motivating the development of multi‐target‐directed ligands (MTDLs). In this study, a novel series of benzimidazolone‐based hybrids incorporating piperazine, coumarin, and triazole moieties was designed,
Fatih Yılmaz, Emre Menteşe, Ozan Emre Eyüpoğlu, Bahittin Kahveci, Mustafa Emirik   +4 more
wiley   +1 more source

ACETYLCHOLINESTERASE DAN BUTYRYLCHOLINESTERASE SEBAGAI PENANDA KERACUNAN PESTISIDA [PDF]

, 2020
Pestisida merupakan bahan perawatan yang sangat penting di bidang pertanian untuk mencapai hasil pertanian yang memuaskan dan berkualitas. Akibatnya, pestisida terus digunakan sepanjang tahun, terutama oleh para petani.
Marcherya, Atika
core  

The interaction of amiloride with acetylcholinesterase and butyrylcholinesterase [PDF]

, 1990
The diuretic drug amiloride was found to be a powerful inhibitor of the reaction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with their specific choline ester substrates. The inhibition constant is in the micromolar range.
Zemach, Lucie, Lucie Zemach, Dina Segal, Shalitin, Yechiel, Yechiel Shalitin, Segal, Dina   +5 more
core   +1 more source

Sulfonamide‐Based 2‐Amino‐1,3,4‐Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Gülnur Arslan Karahan, Başak Gökçe, Muhammed Tilahun Muhammed, Emre Kadir Ayan, Azime Berna Özçelik   +4 more
wiley   +1 more source

Personalized 3D‐Printed Affinisol‐Based Pharmaceutical Delivery Systems: The Case Study for Alternative Sulfonamides for Alzheimer's Disease

Macromolecular Bioscience, Volume 26, Issue 9, September 2026.
Personalized dosage forms engineered via hot‐melt extrusion and FDM 3D‐printing enable the evaluation of novel anti‐Alzheimer's compounds. The study integrates dissolution testing, thermo‐analytical profiling, physico‐chemical characterization, cytotoxicity, and stability to advance personalized medicine in drug development.
Marie Nevyhoštěná, Alena Komersová, Roman Svoboda, Vladimír Pejchal, Adéla Pospíšilová, Jan Muselík, Aleksandra Łapa, Paulina Koczurkiewicz‐Adamczyk   +7 more
wiley   +1 more source

Integrative Phytochemical, Antioxidant, and NLRP3‐Linked and Anti‐Inflammatory Evaluation of Salvia balansae (Aurès Chemotype): Insights Into Its Safety and Therapeutic Potential

ChemistryOpen, Volume 15, Issue 9, September 2026.
An endemic Aurès chemotype of Salvia balansae emerges as a rich source of luteolin, rosmarinic acid, and other polyphenols with potent antioxidant and NLRP3‐linked anti‐inflammatory activities. Protection against experimental inflammation, favorable enzyme‐modulating properties, and a wide safety margin highlight its promise as a pharmaceutical and ...
Khadra Afaf Bendrihem, Messaoud Hachemi, Mohamed Aimene Mihoubi, Fares Mohamed Amine, Majid Sharifi‐Rad, Dalal Houhou, Rahma Guemmaz, Khaled Kherraz, Azzeddine Zeraib, Assia Abdelmalek, Aicha Mouane, Nour Elhouda Ayeb, Chawki Bensuici, Maria Chikha, Kamel Nagaz, Ayomide Victor Atoki, Mohammed Messaoudi   +16 more
wiley   +1 more source

Carbamates with Differential Mechanism of Inhibition Toward Acetylcholinesterase and Butyrylcholinesterase

, 2016
Most carbamates are pseudoirreversible inhibitors of cholinesterases. Phenothiazine carbamates exhibit this inhibition of acetylcholinesterase but produce reversible inhibition of butyrylcholinesterase, suggesting that they do not form a covalent bond ...
Earl Martin (2222803), Ryan Walsh (214451), Robert S. McDonald (2428525), Oksana Lockridge (603079), Katherine V. Darvesh (1886956), Sultan Darvesh (2222800), Sam Mothana (2428522), Diane Mataija (2428528)   +7 more
core   +1 more source

Comprehensive Chemical and Biological Assessment of Orobanche racemosa Extracts Using Chromatographic, In Vitro, In Silico, and Cell‐Based Techniques

ChemistryOpen, Volume 15, Issue 9, September 2026.
Orobanche racemosa can be considered an effective source of natural bioactive agents in designing functional applications. The growing interest in natural product research as a safer and sustainable alternative to synthetic drugs has triggered this study, which evaluates the chemical profile and biological activity of Orobanche racemosa extracts.
Nilofar Nilofar, Enver Saka, Mehmet Veysi Cetiz, Maria J. Rodrigues, Eliana Fernandes, Luisa Custodio, Evren Yildiztugay, Ismail Yapıcı, Ilhami Gulcin, Esraa A. Elhawary, Omayma A. Eldahshan, Abdel Nasser B. Singab, Carlos L. Cespedes‐Acuna, Gokhan Zengin   +13 more
wiley   +1 more source

Topical Donepezil for Cholinergic Modulation in Chronic Wound Repair

Wound Repair and Regeneration, Volume 34, Issue 5, September/October 2026.
ABSTRACT Chronic wounds result from combined defects in vascular perfusion, inflammatory resolution, and epithelial repair. The skin's non‐neuronal cholinergic system (NNCS), formed by keratinocytes, endothelial cells, fibroblasts, and immune cells that synthesise and respond to acetylcholine (ACh), helps coordinate these processes through muscarinic ...
Hui‐Qi Qu, Charlly Kao, Hakon Hakonarson   +2 more
wiley   +1 more source

Butyrylcholinesterase Protein Ends in the Pathogenesis of Alzheimer’s Disease—Could BCHE Genotyping Be Helpful in Alzheimer’s Therapy?

Biomolecules, 2019
Late-onset Alzheimer’s disease (AD) is clinically characterized by a progressive decline of memory and other cognitive functions leading to the loss of the ability to perform everyday activities.
Jacek Jasiecki, Bartosz Wasąg
doaj   +1 more source