Results 71 to 80 of about 14,374 (222)

Clinical study of butyrylcholinesterase and heparin binding protein as early markers of traumatic inflammation

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 4, August 2026.
Abstract Background To observe the changes of butyrylcholinesterase (BChE) and heparin binding protein (HBP) in post‐traumatic inflammation, in order to determine whether they can be used as early diagnostic indicators of post‐traumatic inflammation. Methods Injury severity score (ISS) was used to evaluate the severity of trauma.
Huiying Zhang, Hui Liu, Jianguo Wang
wiley   +1 more source

Synthesis and biological evaluation of 3–(4-aminophenyl)-coumarin derivatives as potential anti-Alzheimer’s disease agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The work is focused on the design of drugs that prevent and treat Alzheimer’s disease (AD) and its complications. A series of 3–(4-aminophenyl)-coumarin derivatives designed, synthesised, fully characterised and evaluated in vitro/vivo.
Yu-Heng Hu, Jie Yang, Yun Zhang, Ke-Chun Liu, Teng Liu, Jie Sun, Xiao-Jing Wang   +6 more
doaj   +1 more source

Evaluation of cholinergic enzymes and selected biochemical parameters in the serum of patients with a diagnosis of acute subarachnoid hemorrhage

Translational Neuroscience, 2023
Spontaneous subarachnoid hemorrhage (SAH) is the most severe form of hemorrhagic stroke and accounts for 5–7% of all strokes. Several chemical enzymes and cytokines are thought to cause reactions that may affect the mortality and morbidity of SAH ...
Aycan Abdurrahman, Tas Abdurrahim, Yeltekin Asli Cilingir, El-Tekreti Sama Amer Abbas, Arslan Ayse, Arslan Mustafa, Aycan Nur   +6 more
doaj   +1 more source

Error Traps in Pediatric Neuromuscular Block

Pediatric Anesthesia, Volume 36, Issue 8, Page 887-898, August 2026.
ABSTRACT Background Neuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological ...
Gabriel Soares de Sousa, Debra Faulk, Vinicius Caldeira Quintao, Niekoo Abbasian, Hans D. de Boer, Ricardo Vieira Carlos   +5 more
wiley   +1 more source

A model of glycosylated human butyrylcholinesterase [PDF]

Molecular BioSystems, 2013
Abstract Human butyrylcholinesterase (BChE) and its mutants have shown great potential in treating cocaine overdose and addiction. In order to effectively suppress cocaine reward in the brain for a long period of time after an exogenous cocaine hydrolase administration, the therapeutic enzyme should have not only a high catalytic ...
Lei, Fang, Fang, Zheng, Chang-Guo, Zhan
openaire   +2 more sources

Rivastigmine–Bambuterol Hybrids as Selective Butyrylcholinesterase Inhibitors [PDF]

, 2023
Selective butyrylcholinesterase inhibitors are considered promising drug candidates for the treatment of Alzheimer’s disease. In this work, one rivastigmine–bambuterol hybrid (MTR-1) and fourteen of its analogues were synthesized, purified ...
Jie Wu, Wen Tan, Zekai Tan, Marco Pistolozzi   +3 more
core   +1 more source

Influence of N‐Functionalization of Amiridine on the Biological Activity of Its Conjugates as Multitarget Agents for Potential Treatment of Alzheimer's Disease

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
New conjugates of amiridine and salicylimine/amine with an N‐acylalkylene spacer were synthesized. N‐acylation of amiridine conjugates leads to a decrease in their protonation, resulting in a substantial reduction in anticholinesterase activity and relative inability to block Aβ42 self‐aggregation compared to previously studied analogs with an N ...
Galina F. Makhaeva, Tatiana Y. Astakhova, Maria V. Grishchenko, Tatiana S. Shteinberg, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Pavel G. Pronkin, Elena N. Timokhina, Eugene V. Radchenko, Evgeny V. Shchegolkov, Yanina V. Burgart, Victor I. Saloutin, Valery N. Charushin, Rudy J. Richardson   +14 more
wiley   +1 more source

Steady-State Kinetics of Rat Intestinal Butyrylcholinesterase [PDF]

, 2008
Objectives: Butyrylcholinesterase is a major detoxification enzyme found in many tissues and body fluids of different organisms. Here, we investigated the steady state kinetics and the effects of heat on soluble butyrylcholinesterase purified from rat ...
BODUR, EBRU, YILDIZ, Oezlem, COKUGRAS, A. Nese, OEZER, Nazmi   +3 more
core  

Comprehensive Chemical and Biological Evaluation of Rosa damascena Plant Parts and Industrial Residues Using FTIR‐ATR and LC–MS/MS

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Rosa damascena flowers, buds, leaves, branches, and hydrodistillation by‐products were investigated using FTIR‐ATR, LC–MS/MS, and a series of biological assays. The integrated approach highlighted the chemical diversity and bioactive potential of both plant materials and industrial processing residues, supporting their sustainable valorization ...
Burak Bayrak, Hafize Yuca, Yasemin Beyza Budak, Satuk Buğra Alkuyruk, Elif Beyza Özer, Gülnur Ekşi Bona, Bilge Aydın, Mehmet Karadayı, Yusuf Gülşahin, Alptuğ Atila, Gamze Göger, Songul Karakaya   +11 more
wiley   +1 more source

The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26 [PDF]

, 1991
Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase. Acetylcholinesterase functions in the transmission of nerve impulses, whereas the physiological function of butyrylcholinesterase remains unknown ...
La Du, Bert N., Gardner, H. A. R., McAlpine, P. J., Lockridge, Oksana, Allderdice, P. W., Galutira, D.   +5 more
core   +1 more source